原发性膝骨关节炎易感基因多态性位点的系统综述

doi:10.3969/j.issn.1006-9771.2022.07.010

Abstract

Abstract:

Objective To conduct a systematic review of the susceptibility gene polymorphism sites of primary knee osteoarthritis (PKO).

Methods The literature on genetic susceptibility and gene polymorphisms of PKO were retrieved from PubMed, Web of Science, CNKI, Wanfang Data, and China Biomedical Literature Database from establishment of the library to December, 2020, and systematically reviewed.

Results A total of 42 papers on the polymorphism sites of human PKO susceptibility genes were included, involving cellular signaling pathways related to PKO pathogenesis, including inflammatory response, receptor signaling pathway, transcription factor signaling pathway, bone-related signaling pathway, etc. Multiple gene polymorphism sites located in inflammatory factor genes, chemokine genes, Toll-like receptor genes, transcription factor genes, obesity-related genes, and bone-related genes.

Conclusion Inflammatory factor genes and bone-associated allele polymorphisms are likely to be related to PKO susceptibility.

Key words: primary knee osteoarthritis, genetic susceptibility, single nucleotide polymorphism, therapeutic targets, systematic review

CLC Number:

R684.3

LUO Shengfei,HU Zhibo,WANG Ninghua,MIN Hongwei,ZHANG Dejian,LIU Kemin. Susceptibility gene polymorphisms of primary knee osteoarthritis: a systematic review[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2022, 28(7): 803-808.

Figures/Tables 4

References 43

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研究	国家	组别	n	基因型/n
研究	国家	组别	n	GG	AG	AA
Abdel Galil等^[6](2017)	埃及	病例组对照组	210 210	180 115	25 82	5 13
Singh等^[7](2021)	印度	病例组对照组	279 287	204 161	51 85	24 41

研究	国家	组别	n	基因型/n
研究	国家	组别	n	GG	AG	AA
Bai等^[14](2019)	中国	病例组对照组	594 576	189 207	271 265	134 104
张培莉等^[15](2019)	中国	病例组对照组	127 127	83 69	35 51	9 7

研究	国家	组别	n	基因型/n
研究	国家	组别	n	CC	TC	TT
Yang等^[19](2013)	中国	病例组对照组	208 211	28 18	107 101	73 92
Balbaloglu等^[23](2017)	土耳其	病例组对照组	272 296	95 105	120 158	57 33
Zheng等^[22](2017)	中国	病例组对照组	728 1221	252 390	371 590	105 241

Susceptibility gene polymorphisms of primary knee osteoarthritis: a systematic review

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