阿尔茨海默病患者大脑白质变化的弥散张量成像研究进展

doi:10.3969/j.issn.1006-9771.2017.07.007

摘要/Abstract

摘要： 弥散张量成像(DTI)能活体内检测大脑白质纤维的完整性。DTI研究显示,阿尔茨海默病(AD)患者和轻度认知障碍患者都出现多个部位大脑白质损害,大脑白质的变化与认知功能下降密切相关,而不同部位的白质损害可能有不同的临床表现。DTI有可能用于监测AD进展和治疗效果评价。

关键词: 阿尔茨海默病, 白质, 弥散张量成像, 综述

Abstract: Diffusion tensor imaging (DTI) can detect the integrity of white matter in vivo, through which various white matter damages of the brains have been found in patients with Alzheimer's disease (AD), even mild cognitive impairment. These damages of white matter may relate to the impairment of cognitive function, otherwise, damages in various area may result in various clinical features. DTI may further be used in the study of AD development and therapeutic evaluation.

Key words: Alzheimer's disease, white matter, diffusion tensor imaging, review

中图分类号:

R749.1

张秀峰, 陈立典. 阿尔茨海默病患者大脑白质变化的弥散张量成像研究进展[J]. 《中国康复理论与实践》, 2017, 23(7): 775-778.

ZHANG Xiu-feng, CHEN Li-dian. White Matter Damages in Alzheimer's Disease Found with Diffusion Tensor Imaging (review)[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2017, 23(7): 775-778.

参考文献

[1] Foley SF, Tansey KE, Caseras X, et al. Multimodal brain imaging reveals structural differences in Alzheimer's disease polygenic risk carriers: a study in healthy young adults [J]. Biol Psychiatry, 2017, 81(2): 154-161.
[2] Sindi S, Mangialasche F, Kivipelto M. Advances in the prevention of Alzheimer's disease [J]. F1000Prime Rep, 2015, 7: 50.
[3] Knight MJ, McCann B, Kauppinen RA, et al. Magnetic resonance imaging to detect early molecular and cellular changes in Alzheimer's disease [J]. Front Aging Neurosci, 2016, 8: 139.
[4] Filley CM, Fields RD. White matter and cognition: making the connection [J]. J Neurophysiol, 2016, 116(5): 2093-2104.
[5] 孟明,董春波,宋清伟,等. 弥散张量成像对阿尔茨海默病脑白质改变的评价[J]. 中国神经精神疾病杂志, 2016, 42(3): 134-140.
[6] Sexton CE, Mackay CE, Lonie JA, et al. MRI correlates of episodic memory in Alzheimer's disease, mild cognitive impairment, and healthy aging [J]. Psychiatry Res, 2010, 184(1): 57-62.
[7] Nowrangi MA, Okonkwo O, Lyketsos C, et al. Atlas-based diffusion tensor imaging correlates of executive function [J]. J Alzheimers Dis, 2015, 44(2): 585-598.
[8] Chang YL, Chen TF, Shih YC, et al. Regional cingulum disruption, not gray matter atrophy, detects cognitive changes in amnestic mild cognitive impairment subtypes [J]. J Alzheimers Dis, 2015, 44(1): 125-138.
[9] Hong YJ, Yoon B, Shim YS, et al. Gray and white matter degenerations in subjective memory impairment: comparisons with normal controls and mild cognitive impairment [J]. J Korean Med Sci, 2015, 30(11): 1652-1658.
[10] Ouyang X, Chen K, Yao L, et al. Independent component analysis-based identification of covariance patterns of microstructural white matter damage in Alzheimer's disease [J]. PLoS One, 2015, 10(3): e0119714.
[11] Mayo CD, Mazerolle EL, Ritchie L, et al. Longitudinal changes in microstructural white matter metrics in Alzheimer's disease [J]. Neuroimage Clin, 2017, 13: 330-338.
[12] Zhu QY, Bi SW, Yao XT, et al. Disruption of thalamic connectivity in Alzheimer's disease: a diffusion tensor imaging study [J]. Metab Brain Dis, 2015, 30(5): 1295-1308.
[13] Duan L, Zan W, Hao S, et al. Disrupted white matter integrity is associated with cognitive deficits in patients with amnestic mild cognitive impairment: An atlas-based study [J]. SAGE Open Med, 2016, 4: 2050312116648812.
[14] Liu J, Liang P, Yin L, et al. White matter abnormalities in two different subtypes of amnestic mild cognitive impairment [J]. PLoS One, 2017, 12(1): e0170185.
[15] Hiyoshi-Taniguchi K, Oishi N, Namiki C, et al. The uncinate fasciculus as a predictor of conversion from amnestic mild cognitive impairment to Alzheimer disease [J]. J Neuroimaging, 2015, 25(5): 748-753.
[16] Nishioka C, Poh C, Sun SW. Diffusion tensor imaging reveals visual pathway damage in patients with mild cognitive impairment and Alzheimer's disease [J]. J Alzheimers Dis, 2015, 45(1): 97-107.
[17] Cooley SA, Cabeen RP, Laidlaw DH, et al. Posterior brain white matter abnormalities in older adults with probable mild cognitive impairment [J]. J Clin Exp Neuropsychol, 2015, 37(1): 61-69.
[18] Fischer FU, Wolf D, Scheurich A, et al. Altered whole brain white matter networks in preclinical Alzheimer's disease [J]. Neuroimage Clin, 2015, 8: 660-666.
[19] Zhuang L, Sachdev PS, Trollor JN, et al. Microstructural white matter changes, not hippocampal atrophy, detect early amnestic mild cognitive impairment [J]. PLoS One, 2013, 8(3): e58887.
[20] Bai F, Zhang Z, Watson DR, et al. Abnormal white matter independent of hippocampal atrophy in amnestic type mild cognitive impairment [J]. Neurosci Lett, 2009, 462(2): 147-151.
[21] Sanchez-Valle R, Monte GC, SalaLlonch R, et al. White matter abnormalities track disease progression in PSEN1 autosomal dominant Alzheimer's disease [J]. J Alzheimers Dis, 2016, 51(3): 827-835.
[22] Li X, Westman E, Ståhlbom AK, et al. White matter changes in familial Alzheimer's disease [J]. J Intern Med, 2015, 278(2): 211-218.
[23] Perea RD, Vidoni ED, Morris JK, et al. Cardiorespiratory fitness and white matter integrity in Alzheimer's disease [J]. Brain Imaging Behav, 2016, 10(3): 660-668.
[24] Zhu Q, Lin M, Bi S, et al. Impaired frontolimbic connectivity and depressive symptoms in patients with Alzheimer's disease [J]. Dement Geriatr Cogn Disord, 2016, 41(5-6): 281-291.
[25] Agüera-Ortiz L, Hernandez-Tamames JA, Martinez-Martin P, et al. Structural correlates of apathy in Alzheimer's disease: a multimodal MRI study [J]. Int J Geriatr Psychiatry, 2016. [Epub ahead of print].
[26] Alves GS, Oertel KV, Knöchel C, et al. Integrating retrogenesis theory to Alzheimer's disease pathology: insight from DTI-TBSS investigation of the white matter microstructural integrity [J]. Biomed Res Int, 2015, 2015: 291658
[27] Ouyang X, Chen K, Yao L, et al. Simultaneous changes in gray matter volume and white matter fractional anisotropy in Alzheimer's disease revealed by multimodal CCA and joint ICA [J]. Neuroscience, 2015, 301: 553-562.
[28] Caso F, Agosta F, Filippi M. Insights into white matter damage in Alzheimer's disease: from postmortem to in vivo diffusion tensor MRI studies [J]. Neurodegener Dis, 2016, 16(1-2): 26-33.
[29] Benitez A, Fieremans E, Jensen JH, et al. White matter tract integrity metrics reflect the vulnerability of late-myelinating tracts in Alzheimer's disease [J]. Neuroimage Clin, 2014, 4: 64-71.
[30] Stricker NH, Salat DH, Kuhn TP, et al. Mild cognitive impairment is associated with white matter integrity changes in late-myelinating regions within the corpus callosum [J]. Am J Alzheimers Dis Other Demen, 2016, 31(1): 68-75.
[31] Melah KE, Lu YF, Hoscheidt SM, et al. CSF markers of Alzheimer's pathology and microglial activation are associated with altered white matter microstructure in asymptomatic adults at risk for Alzheimer's disease [J]. J Alzheimers Dis, 2016, 50(3): 873-886.
[32] Badea A, Kane L, Anderson RJ, et al. The fornix provides multiple biomarkers to characterize circuit disruption in a mouse model of Alzheimer's disease [J]. Neuroimage, 2016, 142: 498-511.
[33] Maggie W, Jennifer EN, Vivek JS, et al. Metabolic, inflammatory, and microvascular determinants of white matter disease and cognitive decline [J]. Am J Neurodegener Dis, 2016, 5(5): 171-177
[34] Li X, Li TQ, Andreasen N, et al. The association between biomarkers in cerebrospinal fluid and structural changes in the brain in patients with Alzheimer's disease [J]. J Intern Med, 2014, 275(4): 418-427.
[35] Amlien IK, Fjell AM, Walhovd KB, et al. Mild cognitive impairment: cerebrospinal fluid tau biomarker pathologic levels and longitudinal changes in white matter integrity [J]. Radiology, 2013, 266(1): 295-303.
[36] Sachdev PS, Zhuang L, Braidy N, et al. Is Alzheimer's a disease of the white matter? [J]. Curr Opin Psychiatry, 2013, 26(3): 244-251.
[37] Brueggen K, Dyrba M, Barkhof F, et al. Basal forebrain and hippocampus as predictors of conversion to Alzheimer's disease in patients with mild cognitive impairment–a multicenter DTI and volumetry study [J]. J Alzheimers Dis, 2015, 48(1): 197-204.