《Chinese Journal of Rehabilitation Theory and Practice》 ›› 2016, Vol. 22 ›› Issue (12): 1416-1415.doi: 10.3969/j.issn.1006-9771.2016.12.011

• CONTENTS • Previous Articles     Next Articles

Role of Microglia Autophagy in Ischemic Stroke (review)

WANG Dong, HOU Bo-ru, YANG Wen-zhen, KANG Jun-lin, REN Hai-jun   

  1. Department of Neurosurgery, Second Hospital Affiliated Lanzhou University, Lanzhou, Gansu 730000, China
  • Received:2016-09-09 Published:2016-12-25 Online:2017-01-15
  • Contact: REN Hai-jun. E-mail: baiyunguan@hotmail.com

Abstract: Autophagy plays an important role in the regulation of activation and inflammation of microglia after ischemic stroke. The interaction between autophagy of microglia and the inflammation mediated by microglia after ischemic stroke was complex and a large number of molecules were involved. The receptors of microglia activation and related substances may be possible mechanism in the regulation of microglia autophagy. Autophagy inhibitors and microglia receptor targeting therapy may provide new strategies for the clinical treatment of ischemic stroke. This paper summarized the progress of microglia autophagy after ischemic stroke.

Key words: ischemic stroke, microglia, autophagy, review

CLC Number: