脑梗死患者康复治疗前后血管内皮生长因子水平的比较

doi:10.3969/j.issn.1006-9771.2016.12.015

Abstract

Abstract: Objective To investigate the change of serum vascular endothelial growth factor (VEGF) in cerebral infarction before and after rehabilitation.Methods Forty-eight patients with first cerebral infarction were enrolled from June, 2014 to August, 2016 in Beijing Bo'ai Hospital. Level of serum VEGF was measured by enzyme-linked immunosorbent assay (ELISA) before and six weeks after rehabilitation. The level of serum VEGF of 33 normal subjects was compared with the patients'.Results The level of serum VEGF was higher in the patients group than in the control group before and six weeks after rehabilitation (t>2.540, P<0.05). The level of VEGF was higher in the large area infarction group (>4 cm) than in the small area infarction group (≤4 cm) (t=4.436, P<0.05), and was higher in the short course (less than one month) infarction group than in the long course (more than one month) group (t=2.316, P<0.05).Conclusion VEGF can be maintained in high level after rehabilitation.

Key words: vascular endothelial growth factor, cerebral infarction, rehabilitation, vascular regeneration

CLC Number:

R743.3

LU Li-ping, SANG De-chun, BAI Fan, CHEN Hui, YANG Fan, CHU Hong-yu, ZHANG Xiao-yu, LI Xin, LIU Jian-hua. Level of Serum Vascular Endothelial Growth Factor in Patients with Cerebral Infarction before and after Rehabilitation[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2016, 22(12): 1434-1433.

References

[1] Wang YQ, Guo X, Qiu H, et al. VEGF overexpression enhances striatal neurogenesis in brain of adult rat after a transient middle cerebral artery occlusion [J]. J Neurosci Res, 2007, 85(1): 73-82.
[2] 黄培坚,张国华,文国强,等. 尤瑞克林对急性脑梗死患者VEGF水平的影响[J]. 中国神经精神疾病杂志, 2012, 38(6): 370-372.
[3] 易建,姚汉金,刘明瑜,等. 尤瑞克林联合依达拉奉治疗急性脑梗死疗效及血清hs-CRP和VEGF水平变化[J]. 微循环学杂志, 2010, 20(3): 48-49.
[4] Wang J, An Q, Li D, et al. Heparin and vascular endothelial growth factor loaded poly(L-lactide-co-caprolactone) nanofiber covered stent-graft for aneurysm treatment [J]. J Biomed Nanotechnol, 2015, 11(11): 1947-1960.
[5] Kim JH, Kim TH, Jin GZ, et al. Mineralized poly(lactic acid) scaffolds loading vascular endothelial growth factor and the in vivo performance in rat subcutaneous model [J]. J Biomed Mater Res A, 2013, 101(5): 1447-1455.
[6] Delcombel R, Janssen L, Vassy R, et al. New prospects in the roles of the C-terminal domains of VEGF-A and their cooperation for ligand binding, cellular signaling and vessels formation [J]. Angiogenesis, 2013, 16(2): 353-371.
[7] Vempati P, Popel AS, MacGabhann F. Extracellular regulation of VEGF: isoforms, proteolysis, and vascular patterning [J]. Cytokine Growth Factor Rev, 2014, 25(1): 1-19.
[8] 王新德. 急性脑血管病诊断标准(第四届全国脑血管修订方案)[J]. 中华神经外科杂志, 1995, 23(6): 670.
[9] 纪树荣. 动疗法技术学[M]. 2版. 北京:华夏出版社, 2011: 296-429.
[10] 朱镛连. 神经康复学[M]. 2版. 北京:人民军医出版社, 2010: 152-154.
[11] 中华人民共和国卫生部医政司. 中国康复医学诊疗规范[M]. 北京:华夏出版社, 1998: 183-184.
[12] Slevin M, Krupinski J, Slowik A, et al. Serial measurement of vascular endothelial growth factor and transforming growth factor-beta1 in serum of patients with acute ischemic stroke [J]. Stroke, 2000, 31(8): 1863-1870.
[13] 马建华. 血管内皮生长因子与脑血管病[J]. 新疆医学, 2006, 36: 119-122.
[14] Zhang ZG, Zhang L, Jiang Q, et al. VEGF enhance angiogenesis and promotes blood-brain barrier leakage in the ischemic brain [J]. J Clin In Vest, 2000, 106: 829 -838.
[15] 李蕾,刘开祥. VEGF在缺血性脑血管病中的研究进展[J]. 牡丹江医学院学报, 2010, 31(5): 69-71.
[16] 吴远华,朱广旗,曹丽平. VEGF、Ang-2测定在脑梗死患者神经功能缺损程度及预后评估中的应用价值[J]. 现代预防医学, 2012, 39(17): 4548-4552.
[17] 董桂英. 高压氧治疗急性脑梗死的疗效以及对患者血清血管内皮生长因子、促血管生成素Ⅱ的影响[J]. 中国现代医学杂志, 2016, 26(14): 52-57.
[18] 卢利萍,桑德春,邵翠霞,等. 脑卒中偏瘫患者康复治疗前后的三维步态分析[J]. 中国康复理论与实践, 2014, 20(8): 752-755.
[19] 丁晓伟. 运动康复训练联合神经功能重建治疗仪对脑卒中偏瘫患者生活质量的影响[J]. 中国现代医药杂志, 2016, 18(6): 57-59.
[20] 刘春英,郭毅,杨欢,等. 脑卒中偏瘫患者早期运动疗法康复效果的系统评价[J]. 中国循证医学杂志, 2016, 16(2): 166-171.
[21] 郝静,李萌. 强制性运动方案对脑卒中偏瘫上肢功能障碍患者的疗效[J]. 神经损伤与功能重建, 2016, 11(1): 84-85.
[22] 张立,杨佳蕾,艾妮. 自拟益气活血通络方对急性脑梗死患者血清hs-CRP、S100-β、VEGF 及神经功能影响[J]. 现代中西医结合杂志, 2016, 25(17): 1861-1863.
[23] Vogt M, Puntschart A, Geiser J, et al. Molecular adaptations in human skeletal muscle to endurance training under simulated hypoxic conditions [J]. J Appl Physiol, 2001, 91(1): 173-182.
[24] Gustafsson T, Bodin K, Sylven C, et al. Increased expression of VEGF following exercise training in patients with heart failure [J]. Eur J Clin Invest, 2001, 31(4): 362-366.
[25] 李维根,李昭波,高云秋,等. 运动对自发性高血压大鼠心肌血管内皮生长因子及其基因表达的影响[J]. 中国运动医学杂志, 1999, 18(2): 115-116.
[26] 李宪章,张爱梅,赵爱玲,等. 脑梗死患者血清血管内皮生长因子的动态变化[J].中国神经免疫学和神经病学杂志, 2002, 9(1): 58-59.
[27] 范丽君. 脑梗死患者血管内皮生长因子的变化[J]. 河南职工医学院学报, 2003, 15(4): 16-17.

Level of Serum Vascular Endothelial Growth Factor in Patients with Cerebral Infarction before and after Rehabilitation

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