脊髓损伤后恒河猴双下肢体重支撑的改变

doi:10.3969/j.issn.1006-9771.2017.00.001

《Chinese Journal of Rehabilitation Theory and Practice》 ›› 2018, Vol. 24 ›› Issue (3): 266-268.doi: 10.3969/j.issn.1006-9771.2017.00.001

Previous Articles Next Articles

Impairment of Weight Support of Lower Limbs after Spinal Cord Hemi-section in Rhesus Monkeys

ZHAO Wen¹, WEI Rui-han², RAO Jia-sheng², ZHAO Can², TIAN Peng-yu², ZHOU Xia², JI Run³, LI Li-feng³, YANG Zhao-yang^1,2, LI Xiao-guang^1,2

1. Department of Neurobiology, Capital Medical University, Beijing 100069, China;
2. Beijing Key Laboratory for Biomaterials and Neural Regeneration, Department of Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China;
3. Human Biomechanics Laboratory, National Research Center for Rehabilitation Technical Aids, Beijing 100176, China

Received:2017-11-13 Revised:2017-12-07 Published:2018-03-25 Online:2018-03-27
Contact: LI Xiao-guang. E-mail: lxgchina@sina.com
Supported by:
Supported by National Key Research and Development Program (No. 2017YFC1104002; No. 2017YFC1104001); National Natural Science Foundation of China, Key Program (No. 31730030), General Program (No. 31670988; No. 31771053), Emergency Management Program (No. 31650001), Projects of International Cooperation and Exchanges (No. 31320103903); Special Funds for the Authors of Excellent Doctoral Dissertations of Universities and Colleges (No. 201356); and Beijing Science and Technology Program (No. Z171100002217066)

Abstract

Abstract: Objective To observe the influence of spinal cord injury on lower limbs weight support capacity, and the changes with time. Methods Six adult female rhesus monkeys with thoracic (T_7-9) right spinal cord hemi-section were measured the plantar pressure ratio of both lower limbs with Foot-Scan system before, and six and twelve weeks after operation. Results There was no statistical difference between both sides of limbs before operation (Z=-1.330, P>0.05), while the plantar pressure ratio was more on the left limbs six and twelve weeks after operation (Z>4.783, P<0.001). The plantar pressure ratio of right lower limb became less and less during observation (Z=3.191, P<0.001).Conclusion The weight support capacity of affected limbs is injured after spinal cord hemi-section in monkeys, and would become worse without intervention.

Key words: spinal cord injury, lower limbs, body weight, support, rhesus monkeys

CLC Number:

R651.2

ZHAO Wen, WEI Rui-han, RAO Jia-sheng, ZHAO Can, TIAN Peng-yu, ZHOU Xia, JI Run, LI Li-feng, YANG Zhao-yang, LI Xiao-guang. Impairment of Weight Support of Lower Limbs after Spinal Cord Hemi-section in Rhesus Monkeys[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2018, 24(3): 266-268.

References

[1] Li XG, Yang ZY, Zhang AF, et al.Repair of thoracic spinal cord injury by chitosan tube implantation in adult rats[J]. Biomaterials, 2008, 30(6): 1121-1132.
[2] Lee BB, Cripps RA, Fitzharris M, et al.The global map for traumatic spinal cord injury epidemiology: update 2011, global incidence rate[J]. Spinal Cord, 2014, 52(2): 110-116.
[3] 马文静,王鸿勋,孙乃祥,等. TMS-MEP评价大鼠脊髓损伤后运动功能障碍程度的研究[J]. 中国法医学杂志, 2014, 29(2): 104-108.
[4] 樊霄燕,周军杰,曹成福,等. 基于F-Scan三维动态足底压力分析系统的动静态足底压力分析[J]. 中国组织工程研究, 2011, 15(50): 9406-9409.
[5] 陈雁西,俞光荣. F-Scan足底压力步态分析仪临床应用现状[J]. 国际骨科学杂志, 2005, 26(3): 187-189.
[6] 梁成军. 足底压力测量在步态分析及病理足评估中的应用[J]. 中国组织工程研究, 2007, 11(40): 8149-8152.
[7] Demes B, O'Neill MC. Ground reaction forces and center of mass mechanics of bipedal capuchin monkeys: implications for the evolution of human bipedalism[J]. Am J Physical Anthropol, 2013, 150(1): 76-86.
[8] Park IB, Lee S, Kim S, et al.Evaluation of plantar pressure and force in diabetes using Tekscan F-Scan in-shoe foot force and gait analysis system[J]. Febs Lett, 2015, 230(1-2): 61-66.
[9] 王立平,李建设. 足底压力测量技术的发展现状与应用研究[J]. 浙江体育科学, 2004, 26(1): 40-43.
[10] 和瑞婷,葛飞,向沙,等. 伴足溃疡病史的糖尿病周围神经病变患者足底压力分布特点分析[J]. 中国糖尿病杂志, 2016, 8(7): 401-404.
[11] Khalil N, Beis JM, Paysant J, et al.Analyse instrumentale baropodométrique embarquée : place du système F-Scan^® dans l'évaluation de la chirurgie du pied[J]. Médecine Et Chirurgie Du Pied, 2016, 32(3): 77-83.
[12] Catalfamo P, Moser D, Ghoussayni S, et al.Detection of gait events using an F-Scan in-shoe pressure measurement system[J]. Gait Posture, 2008, 28(3): 420-426.
[13] Kong P, De-Heer H.Wearing the F-Scan mobile in-shoe pressure measurement system alters gait characteristics during running[J]. Gait Posture, 2009, 29(1): 143-145.
[14] Grégoire C, Mary BB, James WF, et al.Can experiments in nonhuman primates expedite the translation of treatments for spinal cord injury in humans?[J]. Nature Med, 2017, 13(5): 561-566.
[15] Do-Hun L, Jae KL.Animal models of axon regeneration after spinal cord injury[J]. Neurosci Bull, 2013, 29(4): 436-444.
[16] 宋伟,赵文,魏瑞晗,等. 脊髓损伤恒河猴后肢步态数据处理方法的设计[J]. 中国康复理论与实践, 2013, 19(8): 734-738.
[17] 陈景敏. 脊髓损伤患者的康复指导及心理护理[C]. 北京:世界灾害护理大会, 2014.
[18] 王欣,王宁华,谢斌,等. 功能性电刺激结合圆周运动对脊髓损伤患者下肢功能重建的作用[J]. 中华物理医学与康复杂志, 2011, 33(1): 74-76.
[19] 张扬媚,高云芳. 废用性肌萎缩的研究进展[J]. 中华物理医学与康复杂志, 2012, 34(7): 550-553.
[20] 魏蓉,徐秀群,姚尤梅,等. 足踝肌力康复训练器的研制与应用[J]. 江苏医药, 2015, 41(18): 2227-2228.
[21] 李莉,姜燕. 避免脑梗塞患者肌肉萎缩的护理[J]. 医药前沿, 2014(14): 292.
[22] 杨斌. 失神经后骨骼肌萎缩机制及治疗研究进展[J]. 实用医学杂志, 2009, 25(4): 505-506.
[23] 王光. 细胞生长因子对失神经骨骼肌萎缩的作用机制分析[J]. 医学综述, 2010, 16(18): 2754-2757.
[24] 裴艳宏,刘坤祥. 浅谈失神经骨骼肌萎缩中医药治疗的研究进展[J]. 医学信息, 2013, 8(16): 679-680.
[25] 孙文善,赵晓冬,王余民,等. 穴位埋线防治骨折后废用性肌萎缩临床观察[J]. 中国现代医药杂志, 2015(2): 57-58.

Impairment of Weight Support of Lower Limbs after Spinal Cord Hemi-section in Rhesus Monkeys

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Metrics

Comments

Recommended 0

[1]	LIU Dong, XU Zihan, LI Jiang, JU Ping. Effect of high-frequency repetitive transcranial magnetic stimulation in M1 region combined with dorsolateral prefrontal cortex on electroencephalogram θ frequency band amplitude of patients with neuropathic pain after spinal cord injury [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2024, 30(1): 87-94.
[2]	LI Fang, HUO Su, DU Jubao, LIU Xiuzhen, LI Xiaoshuang, SONG Weiqun. Effect of transcranial direct current stimulation combined with task-oriented rehabilitation training on forelimb motor dysfunction in rats with spinal cord injury [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2023, 29(7): 777-781.
[3]	LIU Ning, LIU Yuquan, ZHU Bin, YU Lingjia, TAN Haining, YANG Yong, LI Xiang. Application of International Standards for Neurological Classification of Spinal Cord Injury in China: a bibliometrics re-analysis [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2023, 29(7): 808-815.
[4]	WANG Yiji, ZHOU Hongjun, HE Zejia, LIU Genlin, ZHENG Ying, HAO Chunxia, WEI Bo, KANG Haiqiong, ZHANG Ying, LU Xiaolei, YUAN Yuan, MENG Qianru. Relationship between symmetry of lower limb function and gait symmetry in patients with incomplete spinal cord injury [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2023, 29(6): 639-645.
[5]	YUAN Yuan, ZHOU Hongjun, CONG Xinying, LIU Genlin, WEI Bo, ZHENG Ying, HAO Chunxia, ZHANG Ying, WANG Yiji, KANG Haiqiong, LU Xiaolei, MENG Qianru. Relationship between impairment and magnetic resonance imaging finding in patients with traumatic cervical spinal cord injury after surgery [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2023, 29(6): 725-730.
[6]	JIANG Le, DU Liangjie, HUANG Fubiao. Mood states and cognitive performance in patients with complete spinal cord injury [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2023, 29(5): 576-581.
[7]	GUO Shuang, XIE Yongqi, ZHANG Liang, ZHANG Chunjia, PENG Run, YANG Degang, YANG Mingliang. Related factors and prediction model for neurological outcome of dance-associated pediatric spinal cord injury without radiographic abnormality [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2023, 29(5): 582-589.
[8]	ZHANG Yuan, YANG Jian. Exercise rehabilitation interventions for people with spinal cord injury and their health benefits: a systematic review of systematic reviews based on ICD-11 and ICF [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2023, 29(12): 1377-1385.
[9]	SHI Xiaoyu, YANG Jian. Adaptive physical activity and its health benefits for patients with spinal cord injury based on ICF: a scoping review [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2023, 29(12): 1395-1404.
[10]	LIU Genlin,ZHOU Hongjun,LI Jianjun,WEI Bo,ZHENG Ying,HAO Chunxia,ZHANG Ying,WANG Yiji,KANG Haiqiong,LU Xiaolei,YUAN Yuan,MENG Qianru. Advance in neurological classification of spinal cord injury with complications [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2022, 28(8): 934-938.
[11]	KANG Haiqiong,ZHOU Hongjun,LIU Genlin,WEI Bo,ZHENG Ying,ZHANG Ying,HAO Chunxia,WANG Yiji,LU Xiaolei,YUAN Yuan,MENG Qianru. Changes of bone mineral density in distal femur and proximal tibia in patients with spinal cord injury [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2022, 28(7): 855-858.
[12]	CHAI Li,WANG Mei. Effect of track body weight support walking training on lower limb motor function in stroke patients: based on ICF Core Set for Stroke [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2022, 28(6): 653-658.
[13]	ZHANG Miaoyuan,HE Ying,LI Xiaoxia,PENG Min,ZHANG Lei,LIU Shuying,KONG Ying. Self-management status and related factors of patients with intermittent clean catheterization after spinal cord injury [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2022, 28(6): 716-724.
[14]	ZHOU Xiaojue,FENG Jing,PANG Rizhao,LIU Jie,ZHANG Anren. Every-other-day fasting attenuated inflammation in rats after spinal cord injury via the aryl hydrocarbon receptor/suppressor of cytokine signaling 2/nuclear transcription factor-κB signaling pathway [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2022, 28(5): 544-551.
[15]	WEI Juanfang,WANG Linjie,CUI Yanru,CEN Qiuyu,ZHANG Anren. Effects of bone marrow mesenchymal stem cells derived exosomes on spinal cord injured animals: a systematic review [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2022, 28(5): 585-592.