《Chinese Journal of Rehabilitation Theory and Practice》 ›› 2017, Vol. 23 ›› Issue (1): 42-45.doi: 10.3969/j.issn.1006-9771.2017.01.010

Previous Articles     Next Articles

Role of Microglia in Damage after Ischemic Stroke (review)

WANG Dong, HOU Bo-ru, YANG Wen-zhen, KANG Jun-lin, REN Hai-jun   

  1. Department of Neurosurgery, Second Hospital Affiliated to Lanzhou University, Lanzhou, Gansu 730000, China
  • Received:2016-09-09 Published:2017-01-20 Online:2017-02-17
  • Contact: REN Hai-jun. E-mail: baiyunguan@hotmail.com

Abstract: Microglial cells are the resident immune cells of brain. The activated microglia produces a range of deleterious substances, which plays an important role in the inflammation of post-stroke, such as superoxide, nitric oxide, matrix metalloproteinases, etc. The activation of microglia may involve triggering receptor expressed on myeloid cells-1, Toll-like receptors 4, peroxisome proliferator-activated receptors, purinergic receptors, etc. Intervention targeted to microglial receptor is becoming a new strategy for ischemic stroke.

Key words: ischemic stroke, microglia, injury, receptors, review

CLC Number: