《Chinese Journal of Rehabilitation Theory and Practice》 ›› 2017, Vol. 23 ›› Issue (4): 406-409.doi: 10.3969/j.issn.1006-9771.2017.04.009

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Relationship between Cancer-related Fatigue and Hypothalamic-pituitary-adrenal Axis (review)

SU Ling-zi1, LI Bai2   

  1. 1. Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China;
    2. Department of Rehabilitation, Shanghai Changhai Hospital, Shanghai 200433, China
  • Received:2016-07-31 Published:2017-04-05 Online:2017-05-17
  • Contact: LI Bai. E-mail: libai9@126.com

Abstract: Cancer-related fatigue survivors have been found to have lower morning serum cortisol levels, flattened diurnal cortisol cycles, and decreased cortisol responses to psychological stress. The mechanism may be related to the inflammation caused by disorder of hypothalamus-pituitary-adrenal axis, and there are also some evidences to support that cortisol can be used to reduce cancer-related fatigue. This study introduced the research progress of the relationship between cancer-related fatigue and hypothalamus-pituitary-adrenal axis.

Key words: cancer-related fatigue, hypothalamic-pituitary-adrenal axis, cortisol, review

CLC Number: