选择性β1受体阻滞剂对高血压患者运动耐力的影响

doi:10.3969/j.issn.1006-9771.2017.04.018

Abstract

Abstract: Objective To explore the effect of selective beta-1 adrenoreceptor blocker on exercise tolerance in patients with hypertension. Methods From May, 2015 to May, 2016, 72 patients with hypertension were divided into two groups, according to whether taking the selective beta-1 receptor blocker. Group A (n=35) took the selective beta-1 receptor blocker two weeks before cardiopulmonary exercise, while group B (n=37) did not take anything at the same time. The exercise tolerance was compared between two groups. Results The maximal systolic blood pressure, peak heart rate, one-minute heart rate after exercise (HR1) and rate-pressure product were lower in group A than in group B (t>2.012, P<0.05), however, the recovery value of HR1 was higher in group A than in group B (t=2.100, P<0.05). There was no difference in both peak power and peak oxygen uptake between two groups (t<0.689, P>0.05). Conclusion The selective beta-1 adrenoreceptor blocker could reduce myocardial oxygen consumption, and improve vagus nerve activity, but did not reduce exercise tolerance in patients with hypertension.

Key words: hypertension, selective beta-1 adrenoreceptor blocker, cardiopulmonary exercise testing

CLC Number:

R544.1

LI Shou-lin,a, ZHANG Yan,a, LIU Jie,a, YANG Wei,a, LIU Li-jun,a, ZHENG Zhi-chang,a, LIN Wei,a, WANG Xiao-rong,a, WANG Guo-dong,a, FENG Li-hong,a, CHEN Si-yuan,a, YANG Zu-fu,b. Effect of Selective beta-1 Adrenoreceptor Blocker on Exercise Tolerance in Patients with Hypertention　[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2017, 23(4): 446-448.

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Effect of Selective beta-1 Adrenoreceptor Blocker on Exercise Tolerance in Patients with Hypertention

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