影像学技术应用于阿尔茨海默病早期诊断的研究进展

doi:10.3969/j.issn.1006-9771.2017.05.009

Abstract

Abstract: At present, the clinical diagnosis of Alzheimer's disease (AD) is mainly based on clinical history, however, the sensitivity and accuracy is limited. Positron emission computed tomography can accurately diagnose AD early by glucose metabolism imaging and biomarker imaging. Magnetic resonance imaging provides the basis for early diagnosis and identification of AD by structural imaging and functional imaging. In recent years, the multi-modality imaging technology closely combines radiology and nuclear medicine, which can more accurately diagnose AD.

Key words: Alzheimer's disease, positron emission computed tomography, magnetic resonance imaging, tracer, review

CLC Number:

R749.1

HUANG Rui, HUA Xue-si, ZHANG Lan. Advance in Imaging Techniques for Early Diagnosis of Alzheimer's Disease (review)[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2017, 23(5): 534-538.

References

[1] Sadhu A, Upadhyay P, Agrawal A, et al. Management of cognitive determinants in senile dementia of Alzheimer's type: therapeutic potential of a novel polyherbal drug product [J]. Clin Drug Investig, 2014, 34(12): 857-869. doi:10.1007/s40261-014-0235-9.
[2] Cuttler JM, Moore ER, Hosfeld VD, et al. Treatment of Alzheimer disease with CT scans: a case report [J]. Dose Response, 2016, 14(2): 1559325816640073. doi:10.1177/1559325816640073.
[3] Geldmacher DS, Kirson NY, Birnbaum HG, et al. Implications of early treatment among Medicaid patients with Alzheimer's disease [J]. Alzheimers Dement, 2014, 10(2): 214-224. doi:10.1016/j.jalz.2013.01.015.
[4] Vemuri P, Lesnick TG, Przybelski SA, et al. Vascular and amyloid pathologies are independent predictors of cognitive decline in normal elderly [J]. Brain, 2015, 138(Pt 3): 761-771. doi:10.1093/brain/awu393.
[5] Yanagisawa D, Amatsubo T, Morikawa S, et al. In vivo detection of amyloid β deposition using 19 F magnetic resonance imaging with a 19 F-containing curcumin derivative in a mouse model of Alzheimer's disease [J]. Neuroscience, 2011, 184: 120-127. doi:10.1016/j.neuroscience.2011.03.071.
[6] Cova I, Clerici F, Rossi A, et al. Weight loss predicts progression of mild cognitive impairment to Alzheimer's disease [J]. PLoS One, 2016, 11(3): e0151710. doi:10.1371/journal.pone.0151710.
[7] Jia J, Zhou A, Wei C, et al. The prevalence of mild cognitive impairment and its etiological subtypes in elderly Chinese [J]. Alzheimers Dement, 2014, 10(4): 439-47. doi:10.1016/j.jalz.2013.09.008.
[8] Ganguli M, Dodge HH, Shen C, et al. Mild cognitive impairment, amnestic type:an epidemiologic study [J]. Neurology, 2004, 63(1): 115-121.
[9] Ward A, Tardiff S, Dye C, et al. Rate of conversion from prodromal Alzheimer's disease to Alzheimer's dementia: a systematic review of the literature [J]. Dement Geriatr Coqn Dis Extra, 2013, 3(1): 320-332. doi:10.1159/000354370.
[10] Shi JM, He X, Lian HJ, et al. Tibetan medicine "RNSP" in treatment of Alzheimer disease [J]. Int J Clin Exp Med, 2015, 8(11): 19874-19880.
[11] Bensaidane MR, Beaureqard JM, Poulin S, et al. Clinical utility of amyloid PET imaging in the differential diagnosis of atypical dementias and its impact on caregivers [J]. J Alzheimers Dis, 2016, 52(4): 1251-1262. doi:10.3233/JAD-151180.
[12] Sun J, Feng X, Liang D, et al. Down-regulation of energy metabolism in Alzheimer's disease is a protective response of neurons to the microenvironment [J]. J Alzheimers Dis, 2012, 28(2): 389-402. doi:10.3233/JAD-2011-111313.
[13] Gallivanone F, Della Rosa PA, Castiglioni I. Statistical voxel-based methods and [18F]FDG PET brain imaging: frontiers for the diagnosis of AD [J]. Curr Alzheimer Res, 2016, 13(6): 682-694.
[14] Pardo JV, Lee JT, Kuskowski MA, et al. Fluorodeoxyglucose positron emission tomography of mild cognitive impairment with clinical follow-up at 3 years [J]. Alzheimers Dement, 2010, 6(4): 326-333. doi:10.1016/j.jalz.2009.09.005.
[15] Takahashi R, Ishii K, Senda M, et al. Equal sensitivity of early and late scans after injection of FDG for the detection of Alzheimer pattern: an analysis of 3D PET data from J-ADNI, a multi-center study [J]. Ann Nucl Med, 2013, 27(5): 452-459. doi:10.1007/s12149-013-0704-x.
[16] Silverman DH, Small GW, Chang CY. Positron emission tomography in evaluation of dementia: regional brain metabolism and long-term outcome [J]. JAMA, 2001, 286(17): 2120-2127.
[17] Pietrini P, Alexander GE, Furey ML, et al. Cerebral metabolic response to passive audiovisual stimulation in patients with Alzheimer's disease and healthy volunteers assessed by PET [J]. J Nucl Med, 2000, 41(4): 575-583.
[18] Laforce R Jr, Buteau JP, Paquet N, et al. The value of PET in mild cognitive impairment, typical and atypical/unclear dementias: a retrospective memory clinic study [J]. Am J Alzheimers Dis Other Demen, 2010, 25(4): 324-332. doi:10.1177/1533317510363468.
[19] Tripathi M, Dhawan V, Peng S, et al. Differential diagnosis of parkinsonian syndromes using F-18 fluorodeoxyglucose positron emission tomography [J]. Neuroradiology, 2013, 55(4): 483-492. doi:10.1007/s00234-012-1132-7.
[20] Eisenmenger LB, Huo EJ, Hoffman JM, et al. Advances in PET imaging of degenerative, cerebrovascular, and traumatic causes of dementia [J]. Semin Nucl Med, 2016, 46(1): 57-87. doi:10.1053/j.semnuclmed.2015.09.003.
[21] Kung HF, Choi SR, Qu W, et al. 18 F stilbenes and styrylpyridines for PET imaging of a beta plaques in Alzheimer's disease：a miniperspective [J]. J Med Chem, 2010, 53(3): 933-941. doi:10.1021/jm901039z.
[22] Rodriguez-Vieitez E, Saint-Aubert L, Carter SF, et al. Diverging longitudinal changes in astrocytosis and amyloid PET in autosomal dominant Alzheimer's disease [J]. Brain, 2016, 139(Pt 3): 922-936. doi:10.1093/brain/awv404.
[23] Liu E, Schmidt ME, Margolin R, et al. Amyloid-β 11 C-PiB-PET imaging results from 2 randomized bapineuzumab phase 3 AD trials [J]. Neurology, 2015, 85(8): 692-700. doi:10.1212/WNL.0000000000001877.
[24] Farid K, Hong YT, Aigbirhio FI, et al. Early-phase 11 C-PIB PET in amyloid angiopathy-related symptomatic cerebral hemorrhage:potential diagnostic value? [J]. PLoS One, 2015, 10(10): e0139926. doi:10.1371/journal.pone.0139926.
[25] Sigurdsson EM, Wadghiri YZ, Blind JA, et al. O3-03-03 In vivo magnetic resonance imaging of amyloid plaques in mice with a non-toxic Aβ derivative [J]. Neurobiol Aging, 2004, 25(4): S57.
[26] Maetzler W, Reimold M, Liepelt I, et al. [11C]PIB binding in Parkinson's disease dementia [J]. Neuroimage, 2008, 39(3): 1027-1033.
[27] Klunk WE, Engler H, Nordberg A, et al. Imaging brain amyloid in Alzheimer′s disease with Pittsburgh Compound-B [J]. Ann Neurol, 2004, 55(3): 306-319.
[28] Fleisher AS, Chen K, Liu X, et al. Using positron emission tomography and florbetapir F18 to image cortical amyloid in patients with mild cognitive impairment or dementia due to Alzheimer disease [J]. Arch Neurol, 2011, 68(11): 1404-1411. doi:10.1001/archneurol.2011.150.
[29] Payoux, P, Delrieu J, Gallini A, et al. Cognitive and functional patterns of nondemented subjects with equivocal visual amyloid PET findings [J]. Eur J Nucl Med Mol Imaging, 2015, 42(9): 1459-1468. doi:10.1007/s00259-015-3067-9.
[30] Johnson KA, Sperling RA, Gidicsin CM, et al. Florbetapir (F18-AV-45) PET to assess amyloid burden in Alzheimer's disease dementia, mild cognitive impairment, and normal aging [J]. Alzheimers Dement, 2013, 9(5 Suppl): S72-S83. doi:10.1016/j.jalz.2012.10.007.
[31] Murray ME, Graff-Radford NR, Ross OA, et al. Neuropathologically defined subtypes of Alzheimer's disease with distinct clinical characteristics: a retrospective study [J]. Lancet Neurol, 2011, 10(9): 785-796. doi:10.1016/S1474-4422(11)70156-9.
[32] Braak H, Braak E. Development of Alzheimer-related neurofibrillary changes in the neocortex inversely recapitulates cortical myelogenesis [J]. Acta Neuropathol, 1996, 92(2): 197-201.
[33] Gao M, Wang M, Zheng QH. Fully automated synthesis of [(18)F]T807, a PET tau tracer for Alzheimer's disease [J]. Bioorg Med Chem Lett, 2015, 25(15): 2953-2957. doi:10.1016/J.Bmcl.2015.05.035.
[34] Agdeppa ED, Kepe V, Liu J, et al. Binding characteristics of radiofluorinated 6-dialkylamino-2-naphthylethylidene derivatives as positron emission tomography imaging probes for beta-amyloid plaques in Alzheimer's disease [J]. J Neurosci, 2001, 21(24): RC189.
[35] Chien DT, Szardenings AK, Bahri S, et al. Early clinical PET imaging results with the novel PHF-tau radioligand [F18]-T808 [J]. J Alzheimers Dis, 2014, 38(1): 171-184. doi:10.3233/JAD-130098.
[36] Kolb H, Attardo G, Mintun M, et al. First case report: image to autopsy correlation for tau imaging with [18F]-T808 (AV-680) [J]. Alzheimers Dement, 2013, 9(4): 844-845.
[37] Korolev IO, Symonds LL, Bozoki AC. Predicting progression from mild cognitive impairment to Alzheimer's dementia using clinical, MRI, and plasma biomarkers via probabilistic pattern classification [J]. PLoS One, 2016, 11(2): e0138866. doi:10.1371/journal.pone.0138866.
[38] Liu L, Fu L, Zhang X, et al. Combination of dynamic (11)C-PIB PET and structural MRI improves diagnosis of Alzheimer's disease [J]. Psychiatry Res, 2015, 233(2): 131-140. doi:10.1016/j.pscychresns.2015.05.014.
[39] Trzepacz PT, Hochstetler H, Yu P, et al. Relationship of hippocampal volume to amyloid burden across diagnostic stages of Alzheimer's disease [J]. Dement Geriatr Cogn Disord, 2016, 41(1-2): 68-79. doi:10.1159/000441351.
[40] Apostolova LG, Dutton RA, Dinov ID, et al. Conversion of mild cognitive impairment to Alzheimer disease predicted by hippocampal atrophy maps [J]. Arch Neurol, 2006, 63(5): 693-699.
[41] McGuinness B, Barrett SL, McIlvenna J, et al. Predicting conversion to dementia in a memory clinic: A standard clinical approach compared with an empirically defined clustering method (latent profile analysis) for mild cognitive impairment subtyping [J]. Alzheimers Dement (Amst), 2015, 1(4): 447-454. doi:10.1016/j.dadm.2015.10.003.
[42] Gorelick PB, Counts SE, Nyenhuis D. Vascular cognitive impairment and dementia [J]. Biochim Biophys Acta, 2016, 1862(5): 860-868. doi:10.1016/j.bbadis.2015.12.015.
[43] Jin M, Pelak VS, Cordes D. Aberrant default mode network in subjects with amnestic mild cognitive impairment using resting-state functional MRI [J]. Magn Reson Imaging, 2012, 30(1): 48-61. doi:10.1016/j.mri.2011.07.007.
[44] Li W, Howard JD, Gottfried JA. Disruption of odour quality coding in piriform cortex mediates olfactory deficits in Alzheimer's disease [J]. Brain, 2010, 133(9): 2714-2726. doi:10.1093/brain/awq209.
[45] Wang J, Eslinger PJ, Doty RL, et al. Olfactory deficit detected by fMRI in early Alzheimer's disease [J]. Brain Res, 2010, 1357: 184-194. doi:10.1016/j.brainres.2010.08.018.
[46] Jin Z, Guan Y, Yu G, et al. Magnetic resonance imaging of postoperative fracture healing process without metal artifact: a preliminary report of a novel animal model [J]. Biomed Res Int, 2016, 2016: 1429892. doi:10.1155/2016/1429892.
[47] Illan IA, Gorriz JM, Ramirez J, et al. Bilateral symmetry aspects in computer-aided Alzheimer's disease diagnosis by single-photon emission-computed tomography imaging [J]. Artif Intell Med, 2012, 56(3): 191-198. doi:10.1016/j.artmed.2012.09.005.
[48] Faria AV, Ratnanather JT, Tward DJ, et al. Linking white matter and deep gray matter alterations in premanifest Huntington disease [J]. Neuroimage Clin, 2016, 11: 450-460. doi:10.1016/j.nicl.2016.02.014.
[49] Dunham CM, Cook AJ 2nd, Paparodis AM, et al. Practical one-dimensional measurements of age-related brain atrophy are validated by 3-dimensional values and clinical outcomes: a retrospective study [J]. BMC Med Imaging, 2016, 16: 32. doi:10.1186/s12880-016-0136-x.
[50] Sverzellati N, Colombi D, Randi G, et al. Computed tomography measurement of rib cage morphometry in emphysema [J]. PLoS One, 2013, 8(7): e68546. doi:10.1371/journal.pone.0068546.
[51] Mahlberg R, Walther S, Kalus P, et al. Pineal calcification in Alzheimer's disease: An in vivo study computed tomography [J]. Neurobiol Aging, 2008, 29(2): 203-209.
[52] Tang Z, Pi X, Chen F, et al. Fifty percent reduced-dose cerebral CT perfusion imaging of Alzheimer's disease: regional blood flow abnormalities [J]. Am J Alzheimers Dis Other Demen, 2012, 27(4): 267-274. doi:10.1177/1533317512447885.
[53] Tang Z, Chen F, Huang J, et al. Low-dose cerebral CT perfusion imaging (CTPI) of senile dementia: diagnostic performance [J]. Arch Gerontol Geriatr, 2013, 56(1): 61-67. doi:10.1016/j.archger.2012.05.009.
[54] Wang L, Zhang Y, He Y, et al. Changes in hippocampal connectivity in the early stages of Alzheimer's disease: evidence from resting state fMRI [J]. Neuroimage, 2006, 31(2): 496-504.
[55] Glaudemans AW, Quintero AM, Signore A. PET/MRI in infectious and inflammatory diseases: will it be a useful improvement? [J]. Eur J Nucl Med Mol Imaging, 2012, 39(5): 745-749. doi:10.1007/s00259-012-2060-9.
[56] Delso G, Martinez-Moller A, Bundschuh RA, et al. The effect of limited MR field of view in MR/PET attenuation correction [J]. Med Phys, 2010, 37(6): 2804-2812.
[57] Degenhardt EK, Witte MM, Gase MG, et al. Florbetapir F18 PET amyloid neuroimaging and characteristics in patients with mild and moderate Alzheimer dementia [J]. Psychosomatics, 2016, 57(2): 208-216. doi:10.1016/j.psym.2015.12.002.
[58] Jack CR Jr, Lowe VJ, Senjem ML, et al. 11 C PiB and structural MRI provide complementary information in imaging of Alzheimer's disease and amnestic mild cognitive impairment [J]. Brain, 2008, 131(Pt 3): 665-680. doi:10.1093/brain/awm336.

Advance in Imaging Techniques for Early Diagnosis of Alzheimer's Disease (review)

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Metrics

Comments

Recommended 0

[1]	SHAO Weiting, LEI Jianghua. Effect of response interruption and redirection as a behavioral intervention on vocal stereotypy in children with autism spectrum disorder: a scoping review [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2024, 30(1): 10-20.
[2]	WANG Hangyu, GE Keke, FAN Yonghong, DU Lilu, ZOU Min, FENG Lei. Effect of active music therapy on cognitive function for older adults with cognitive impairment: a systematic review based on ICD-11 and ICF [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2024, 30(1): 36-43.
[3]	WEN Jianing, JIN Qiuyan, ZHANG Qi, LI Jie, SI Qi. Effect of cognitively engaging physical activity on developing executive function of children and adolescents: a systematic review based on ICF [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2024, 30(1): 44-53.
[4]	GE Keke, FAN Yonghong, WANG Hangyu, DU Lilu, LI Changjiang, ZOU Min. Health benefit of mindfulness intervention for older adults with insomnia disorders: a systematic review [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2024, 30(1): 54-60.
[5]	ZHANG Jingya, ZOU Min, SUN Hongwei, SUN Changlong, ZHU Juntong. Effect of psychological intervention on anxiety or depression in children and adolescents with hearing impairment: a systematic review [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2023, 29(9): 1004-1011.
[6]	WANG Junyu, YANG Yong, YUAN Xun, XIE Ting, ZHUANG Jie. Effect of high-intensity interval training on executive function for healthy children and adolescents: a systematic review [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2023, 29(9): 1012-1020.
[7]	WEI Xiaowei, YANG Jian, WEI Chunyan. Psychological and behavioral benefits of adapted yoga exercise for children with autism spectrum disorder in special education schools: a systematic review [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2023, 29(9): 1021-1028.
[8]	YANG Yaru, YANG Jian. School-based physical activity-related health services and their health benefits within the World Health Organization health-promoting school framework: a systematic review of systematic reviews [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2023, 29(9): 1040-1047.
[9]	WANG He, HAN Liang, KAN Mengfan, YU Shaohong. Efficacy of electrical stimulation on shoulder-hand syndrome after stroke: a systematic review and meta-analysis [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2023, 29(9): 1048-1056.
[10]	SHI Jiawei, LI Lingyu, YANG Haojie, WANG Qinlu, ZOU Haiou. Effect of preoperative prerehabilitation training on total knee arthroplasty: a systematic review of systematic reviews [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2023, 29(9): 1057-1064.
[11]	JIANG Changhao, HUANG Chen, GAO Xiaoyan, DAI Yuanfu, ZHAO Guoming. Effect of neurofeedback training on cognitive function in the elderly: a systematic review [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2023, 29(8): 903-909.
[12]	WEI Xiaowei, YANG Jian, WEI Chunyan, HE Qiling. Adapted physical education programs for psychomotor development in school settings for children with intellectual and developmental disabilities: a systematic review [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2023, 29(8): 910-918.
[13]	ZHANG Yuan, YANG Jian. School health services and effectiveness based on World Health Organization health-promoting school framework: a scoping review [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2023, 29(7): 791-799.
[14]	WANG Shaopu, CHEN Gang. Psychological-behavioral health services and its outcome based on World Health Organization health-promoting school framework: a systematic review of systematic reviews [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2023, 29(7): 800-807.
[15]	JIANG Changhao, GAO Xiaoyan. Effect of acute physical activity on cognitive function in children: a systematic review [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2023, 29(6): 667-672.