《Chinese Journal of Rehabilitation Theory and Practice》 ›› 2017, Vol. 23 ›› Issue (6): 645-648.doi: 10.3969/j.issn.1006-9771.2017.06.005

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Experimental Research Progress of Wnt Signaling Pathway in Spinal Cord Injury Repair (review)

MAN Xia-nan, CHEN Jian-er   

  1. Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China
  • Received:2017-02-14 Revised:2017-03-19 Published:2017-06-25 Online:2017-06-27
  • Contact: Correspondence to CHEN Jian-er. E-mail: cje28@foxmail.com

Abstract: Wnt signaling pathway is one of the important signal transduction systems that involved in regulating nervous system development, which plays an important role in axonal regeneration, neural stem cell proliferation and differentiation into neurons and inhibition of differentiation into glial cells. After spinal cord injury, multiple Wnt protein expresses around the injury site, and some proteins of the Wnt family play an important role in spinal cord injury repair, in which the activation of Wnt/β-catenin signaling pathway is necessary for spinal cord regeneration after spinal cord injury.

Key words: Wnt signaling pathway, spinal cord injury, neural stem cells, Wnt/β-catenin pathway, review

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