脊髓栓系综合征动物模型制作方法的研究进展

doi:10.3969/j.issn.1006-9771.2017.06.012

Abstract

Abstract: Tethered cord syndrome (TCS) is a progressive neurodevelopmental disorder. The TCS model was established mainly using physical and chemical Methods and surgery, but remained problems in failing to fully reflect the progressive course of the human TCS. In the future, it may select a single etiological factor to analyze, and gradually add other factors until we have deeper understanding of this disease.

Key words: tethered cord syndrome, animal model, establishment methods, review

CLC Number:

R651.2

LI Da-peng, YANG De-gang, ZHANG Wen-hao, LIU Chang-bin, CAI Chang, ZHANG Xin, GUO Yun, ZHANG Li-wei, HU An-ming, DU Liang-jie, YANG Ming-liang, LI Jian-jun. Research Progress of Model Establishment for Tethered Cord Syndrome (review)[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2017, 23(6): 677-680.

References

[1] Greene ND, Leung KY, Copp AJ. Inositol, neural tube closure and the prevention of neural tube defects [J]. Birth Defects Res, 2017, 109(2): 68-80.
[2] Toktaş ZO, Yılmaz B, Ekşi MŞ, et al. Lumbar spinal intradural extramedullary lipoma associated with spina bifida and tethered cord [J]. Spine J, 2016, 16(9): e611-e612.
[3] Hendson G, Dunham C, Steinbok P. Histopathology of the filum terminale in children with and without tethered cord syndrome with attention to the elastic tissue within the filum [J]. Childs Nerv Syst, 2016. 32(9): 1683-1692.
[4] Puvirajesinghe TM, Borg JP. Neural tube defects: from a proteomic standpoint [J]. Metabolites, 2015, 5(1): 164-183.
[5] Dreier JW, Andersen AM, Berg-Beckhoff G. Systematic review and meta-analyses: fever in pregnancy and health impacts in the offspring [J]. Pediatrics, 2014, 133(3): e674-e688.
[6] Edwards MJ. Congenital defects in guinea pigs. Following induced hyperthermia during gestation [J]. Arch Pathol, 1967, 84(1): 42-48.
[7] Campbell LR, Dayton DH, Sohal GS. Neural tube defects: a review of human and animal studies on the etiology of neural tube defects [J]. Teratology, 1986. 34(2): 171-187.
[8] 马金龙,高英茂,刘凯,等. 高温致神经管畸形中细胞增殖和细胞凋亡的定量研究[J]. 中国体视学与图像分析, 2001, 6(2): 65-69.
[9] Qing Y, Yingmao G, Shaoling L. Identification and validation of differentially expressed genes in neural tube defects of golden hamster induced by hyperthermia using suppression subtractive hybridization [J]. Int J Neurosci, 2007, 117(8): 1193-1208.
[10] Hosako H, Francisco LE, Martin GS, et al. The roles of p53 and p21 in normal development and hyperthermia-induced malformations [J]. Birth Defects Res B Dev Reprod Toxicol, 2009, 86(1): 40-47.
[11] Barrier M, Dix DJ, Mirkes PE. Inducible 70 kDa heat shock proteins protect embryos from teratogen-induced exencephaly: Analysis using Hspa1a/a1b knockout mice [J]. Birth Defects Res A Clin Mol Teratol, 2009, 85(8): 732-740.
[12] Dheen ST, Tay SS, Boran J, et al. Recent studies on neural tube defects in embryos of diabetic pregnancy: an overview [J]. Curr Med Chem, 2009, 16(18): 2345-2354.
[13] Phelan SA, Ito M, Loeken MR. Neural tube defects in embryos of diabetic mice: role of the Pax-3 gene and apoptosis [J]. Diabetes, 1997, 46(7): 1189-1197.
[14] 马向东,陈必良,辛晓燕,等. 妊娠合并糖尿病诱发胚胎先天性神经管缺陷的MAP激酶及细胞凋亡信号传导机制[J]. 现代妇产科进展, 2003, 12(5): 324-326, 335.
[15] 贾德永. c-Abl在高糖诱导胚胎神经前体细胞凋亡中的作用及作用机制的研究[D]. 济南:山东大学, 2008.
[16] 刘亚千,赵玉琼,王凯,等. 巴马小型猪1型糖尿病模型的建立[J]. 实验动物科学, 2015, 32(4): 1-7.
[17] Goldstein G, Arulanantham K. Neural tube defect and renal anomalies in a child with fetal alcohol syndrome [J]. J Pediatr, 1978, 93(4): 636-637.
[18] Del Campo M, Jones KL. A review of the physical features of the fetal alcohol spectrum disorders [J]. Eur J Med Genet, 2017, 60(1): 55-64.
[19] Zhou FC, Sari Y, Powrozek T, et al. Moderate alcohol exposure compromises neural tube midline development in prenatal brain [J]. Brain Res Dev Brain Res, 2003, 144(1): 43-55.
[20] Flood TJ, Rienks CM, Flores AL, et al. Using state and provincial surveillance programs to reduce risk of recurrence of neural tube defects in the United States and Canada: A missed opportunity? [J]. Birth Defects Res A Clin Mol Teratol, 2016, 106(11): 875-880.
[21] Greene ND, Copp AJ. Mouse models of neural tube defects: investigating preventive mechanisms [J]. Am J Med Genet C Semin Med Genet, 2005, 135C(1): 31-41.
[22] 鲍南,施诚仁,张忠德,等. 鸡胚神经管缺陷脊髓病理与组织化学研究[J]. 中华小儿外科杂志, 1999, 20(2): 45-47.
[23] Fraiser LH, Kanekal S, Kehrer JP. Cyclophosphamide toxicity. Characterising and avoiding the problem [J]. Drugs, 1991. 42(5): 781-795.
[24] Khaksary Mahabady M, Najafzadeh Varzi H, Zareyan Jahromi S. L-carnitine protect against cyclophosphamide induced skeletal and neural tube malformations in rat fetuses [J]. Acta Med Iran, 2015, 53(11): 703-710.
[25] Xiao R, Yu HL, Zhao HF, et al. Developmental neurotoxicity role of cyclophosphamide on post-neural tube closure of rodents in vitro and in vivo [J]. Int J Dev Neurosci, 2007. 25(8): 531-537.
[26] 赵海峰,肖荣,杨燕,等. 环磷酰胺致神经管畸形及可能机理研究[J]. 中国公共卫生, 2002, 18(11): 28-30.
[27] Chen WH, Morriss-Kay GM, Copp AJ. Genesis and prevention of spinal neural tube defects in the curly tail mutant mouse: involvement of retinoic acid and its nuclear receptors RAR-beta and RAR-gamma [J]. Development, 1995, 121(3): 681-691.
[28] Yasuda Y, Konishi H, Kihara T, et al. Developmental anomalies induced by all-trans-retinoic acid in fetal mice: II. Induction of abnormal neuroepithelium [J]. Teratology, 1987, 35(3): 355-366.
[29] Akimova D, Wlodarczyk BJ, Lin Y, et al. Metabolite profiling of whole murine embryos reveals metabolic perturbations associated with maternal valproate-induced neural tube closure defects [J]. 2017, 109(2): 106-119.
[30] Wegner C, Nau H. Alteration of embryonic folate metabolism by valproic acid during organogenesis: implications for mechanism of teratogenesis [J]. Neurology, 1992, 42(4 Suppl 5): 17-24.
[31] Bold J, Sakata-Haga H, Fukui Y. Spinal nerve defects in mouse embryos prenatally exposed to valproic acid [J]. Anat Sci Int, 2016. [Epub ahead of print].
[32] Matsumoto M, Hirata-Koizumi M, Ema M. Potential adverse effects of phthalic acid esters on human health: a review of recent studies on reproduction [J]. Regul Toxicol Pharmacol, 2008, 50(1): 37-49.
[33] Yamada S, Won DJ, Pezeshkpour G. Pathophysiology of tethered cord syndrome and similar complex disorders [J]. Neurosurg Focus, 2007, 23(2): E6.
[34] Koçak A, Kiliç A, Nurlu G, et al. A new model for tethered cord syndrome: a biochemical, electrophysiological, and electron microscopic study [J]. Pediatr Neurosurg, 1997, 26(3): 120-126.
[35] 胡月光,唐彦萍. 兔胎仔先天性脊柱裂模型制作[J]. 遵义医学院学报, 2001, 24(2): 126-127.
[36] Meuli M, Meuli-Simmen C, Yingling CD, et al. Creation of myelomeningocele in utero: a model of functional damage from spinal cord exposure in fetal sheep [J]. J Pediatr Surg, 1995, 30(7): 1028-1032; discussion 1032-1033.
[37] 王旭辉. 脊髓栓系综合征大鼠动物模型的建立及脊髓栓系松解术中肌电监护的应用研究[D]. 济南:山东大学, 2003.
[38] Huang SL, Peng J, Yuan GL, et al. A new model of tethered cord syndrome produced by slow traction [J]. Sci Rep, 2015. 5: 9116.
[39] 陈可夫,贾连顺,史建刚. 脊髓栓系综合征病因的研究进展[J]. 中国矫形外科杂志, 2016, 24(1): 55-57.

Research Progress of Model Establishment for Tethered Cord Syndrome (review)

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Metrics

Comments

Recommended 0

[1]	SHAO Weiting, LEI Jianghua. Effect of response interruption and redirection as a behavioral intervention on vocal stereotypy in children with autism spectrum disorder: a scoping review [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2024, 30(1): 10-20.
[2]	WANG Hangyu, GE Keke, FAN Yonghong, DU Lilu, ZOU Min, FENG Lei. Effect of active music therapy on cognitive function for older adults with cognitive impairment: a systematic review based on ICD-11 and ICF [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2024, 30(1): 36-43.
[3]	WEN Jianing, JIN Qiuyan, ZHANG Qi, LI Jie, SI Qi. Effect of cognitively engaging physical activity on developing executive function of children and adolescents: a systematic review based on ICF [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2024, 30(1): 44-53.
[4]	GE Keke, FAN Yonghong, WANG Hangyu, DU Lilu, LI Changjiang, ZOU Min. Health benefit of mindfulness intervention for older adults with insomnia disorders: a systematic review [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2024, 30(1): 54-60.
[5]	ZHANG Jingya, ZOU Min, SUN Hongwei, SUN Changlong, ZHU Juntong. Effect of psychological intervention on anxiety or depression in children and adolescents with hearing impairment: a systematic review [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2023, 29(9): 1004-1011.
[6]	WANG Junyu, YANG Yong, YUAN Xun, XIE Ting, ZHUANG Jie. Effect of high-intensity interval training on executive function for healthy children and adolescents: a systematic review [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2023, 29(9): 1012-1020.
[7]	WEI Xiaowei, YANG Jian, WEI Chunyan. Psychological and behavioral benefits of adapted yoga exercise for children with autism spectrum disorder in special education schools: a systematic review [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2023, 29(9): 1021-1028.
[8]	YANG Yaru, YANG Jian. School-based physical activity-related health services and their health benefits within the World Health Organization health-promoting school framework: a systematic review of systematic reviews [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2023, 29(9): 1040-1047.
[9]	WANG He, HAN Liang, KAN Mengfan, YU Shaohong. Efficacy of electrical stimulation on shoulder-hand syndrome after stroke: a systematic review and meta-analysis [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2023, 29(9): 1048-1056.
[10]	SHI Jiawei, LI Lingyu, YANG Haojie, WANG Qinlu, ZOU Haiou. Effect of preoperative prerehabilitation training on total knee arthroplasty: a systematic review of systematic reviews [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2023, 29(9): 1057-1064.
[11]	JIANG Changhao, HUANG Chen, GAO Xiaoyan, DAI Yuanfu, ZHAO Guoming. Effect of neurofeedback training on cognitive function in the elderly: a systematic review [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2023, 29(8): 903-909.
[12]	WEI Xiaowei, YANG Jian, WEI Chunyan, HE Qiling. Adapted physical education programs for psychomotor development in school settings for children with intellectual and developmental disabilities: a systematic review [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2023, 29(8): 910-918.
[13]	ZHANG Yuan, YANG Jian. School health services and effectiveness based on World Health Organization health-promoting school framework: a scoping review [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2023, 29(7): 791-799.
[14]	WANG Shaopu, CHEN Gang. Psychological-behavioral health services and its outcome based on World Health Organization health-promoting school framework: a systematic review of systematic reviews [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2023, 29(7): 800-807.
[15]	JIANG Changhao, GAO Xiaoyan. Effect of acute physical activity on cognitive function in children: a systematic review [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2023, 29(6): 667-672.