肌萎缩侧索硬化发病机制的研究进展

doi:10.3969/j.issn.1006-9771.2017.06.014

Abstract

Abstract: Amyotrophic lateral sclerosis (ALS), including the familial and the sporadic, accounts for the most proportion of motor neuron disease. The pathogenesis of ALS covers gene mutation, oxidative stress, excitotoxicity, mitochondrial dysfunction, immune and inflammatory, and so on. With interplay and interrelation, these mechanisms, finally, caused multisystem lesion especially motor neural system.

Key words: amyotrophic lateral sclerosis, pathogenesis mechanism, gene mutation, oxidative stress, excitotoxicity, mitochondrial dysfunction, immune and inflammatory, review

CLC Number:

R746.4

GUO Yong-qiang, LI Sen, ZHANG Hai-hong, WU Ya-min. Advance in Pathogenesis of Amyotrophic Lateral Sclerosis (review)[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2017, 23(6): 685-689.

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Advance in Pathogenesis of Amyotrophic Lateral Sclerosis (review)

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