APP/PS1转基因小鼠学习记忆能力下降与胼胝体脱髓鞘损伤的关系

doi:10.3969/j.issn.1006-9771.2017.09.008

Abstract

Abstract: ObjectiveTo investigate the relationship between learning and memory deficit and demyelination of the corpus callosum in twelve-month old APP/PS1 transgenic mice. MethodsTwelve twelve-month old APP/PS1 transgenic mice were as AD group, and age-matched wild type (WT) littermates were as WT group. Learning and memory ability was tested with Morris water maze, and the morphology of nerve fiber of corpus callosum was detected with Luxol Fast Blue staining. Immunohistochemistry was used to detect myelin basic protein (MBP) in the corpus callosum. Thioflavine S staining was used to detect amyloid plaque in the corpus callosum. ResultsCompared with WT group, the latency increased (Z>2.873, P<0.01) and the times crossing the location of the platform decreased (t=-7.339, P<0.001) in AD group. The nerve fibers were sparse and disorganized, with a lot of vacuoles in the corpus callosum of AD group. The positive expression of MBP in the corpus callosum was significantly decreased (t=-4.481, P<0.001) in AD group compared with WT group. There were amyloid plaques in the corpus callosum of AD group. ConclusionTwelve-month old APP/PS1 transgenic mice exhibit learning and memory deficit, which may be attributed to the deposition of the amyloid plaque mediated demyelinated injury of the corpus callosum.

Key words: Alzheimer's disease, learning and memory, corpus callosum, demyelination, mice

CLC Number:

R749.1

ZHANG Xiu-feng, JIN Hao, LIN Bing-bing, LI Long, SONG Chang-ming, LI Zuan-fang, LIANG Sheng-xiang, MAO Jing-jie, LIU Wei-lin, TAO Jing, CHEN Li-dian. Learning and Memory Deficit and Demyelination of Corpus Callosum in APP/PS1 Transgenic Mice[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2017, 23(9): 1027-1031.

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Learning and Memory Deficit and Demyelination of Corpus Callosum in APP/PS1 Transgenic Mice

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