帕金森病患者血浆和红细胞α-突触核蛋白寡聚体水平及临床意义

doi:10.3969/j.issn.1006-9771.2017.09.022

Abstract

Abstract: ObjectiveTo investigate the level of alpha-synuclein (α-syn) oligomers in peripheral blood plasma and red blood cells (RBC) in patients with Parkinson's disease (PD), and the value of it for diagnosis and evaluation of PD. MethodsFrom March, 2013 to December, 2014, peripheral blood samples were collected from 30 PD patients and 30 healthy coutrols, and the level of α-syn oligomers in plasma and RBC was detected with enzyme linked immunosorbent assay. ResultsThe level of α-syn oligomers was less in both plasma and RBC in the controls than in the patients (t>2.346, P<0.05), and was more in RBC than in plasma in both the controls and the patients (t>2.242, P<0.05). The level of α-syn oligomers of patients did not correlate with their course, Hoehn-Yahr Stage, the scores of Unified Parkinson Disease Rating Scale Part 3, Non-Motor Symptom Quest and Mini-Mental State Examinatlon, both in plasma and RBC (P>0.05). ConclusionThe level of α-syn oligomers in peripheral RBC and plasma may be helpful for diagnosis of PD, but less for the evaluation of the illness.

Key words: Parkinson's disease, alpha-synuclein oligomer, peripheral blood, plasma, red blood cells

CLC Number:

R742.5

LIANG Yang, GU Ying, LI Xiao-hong. Level of Alpha-Synuclein Oligomers in Speripheral Blood Plasma and Red Blood Cells in Parkinson's Disease[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2017, 23(9): 1096-1098.

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Level of Alpha-Synuclein Oligomers in Speripheral Blood Plasma and Red Blood Cells in Parkinson's Disease

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