自噬相关基因Atg7 rs11706903单核苷酸多态性与帕金森病的相关性

doi:10.3969/j.issn.1006-9771.2017.11.015

Abstract

Abstract: Objective To investigate the relationship between the single nucleotide polymorphisms (SNP) of rs11706903, intron region of Atg7, and Parkinson's disease (PD).Methods From January, 2013 to March, 2017, 130 PD patients and 109 healthy subjects were recruited and collected the blood samples. SNPs of rs11706903 were detected with polymerase chain reaction restriction fragment length polymorphism.Results For the patients, the genotype frequencies of rs11706903 were AA 10.00%, AC 52.31% and CC 37.69%; and allele frequencies were A 36.15% and C 63.85%. For the healthy controls, the genotype frequencies of rs11706903 were AA 7.34%, AC 49.54% and CC 43.12%; and allele frequencies were A 32.11% and C 67.89%. There was no significant difference in frequencies of genetypes and alleles beteen two groups (χ²<1.001, P>0.05).Conclusion There might be no relationship between SNPs of Atg7 intron region rs11706903 and PD.

Key words: Parkinson's disease, autophagy-related genes, intron, single nucleotide polymorphisms, rs11706903

CLC Number:

R742.5

HE Peng, ZHAO Xi-yao, CHEN Yu-sen, CHEN Xiao-yi, ZHENG Wei-ming. Association of Single Nucleotide Polymorphisms of Autophagy-related Genes Atg7 Site rs11706903 and Parkinson's Disease[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2017, 23(11): 1313-1316.

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Association of Single Nucleotide Polymorphisms of Autophagy-related Genes Atg7 Site rs11706903 and Parkinson's Disease

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