中药治疗化疗所致周围神经病变的效果

doi:10.3969/j.issn.1006-9771.2017.11.017

Abstract

Abstract: Objective To investigate the efficacy of a Chinese Medicine formula on chemotherapy-induced peripheral neuropathy (CIPN).Methods From April, 2013 to December, 2014, 56 patients were randomized blindly to receive granulas of Chinese Medicine of modified Huangqi-Guizhi Wuwu and Shentong-Zhuyu (treatment group, n=28) or placebo (control group, n=28), for a month. They were assessed with Number Rating Scale (NRS) of symptoms of CIPN, National Cancer Institute's Common Terminology Criteria for Adverse Events (NCI-CTCAE) version 4.0, and European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-30 (EORTC QLQ-C30) before, and four weeks, eight weeks and twelve weeks after treatment.Results The score of NRS (F>9.518, P<0.01)and grade of NCI-CTCAE (Z>3.887, P<0.05) improved in the treatment group compared with those in the control group eight weeks and twelve weeks after treatment. The scores of EORTC QLQ-C30 also improved twelve weeks after treatment, but only significantly in the symptom of fatigue (t=-2.971, P<0.01).Conclusion The Chinese Medicine can release the symptoms of CIPN, decrease the grade of neurotoxicity, and may improve the quality of life somewhat.

Key words: peripheral neuropathy, chemotherapy, Chinese Medicine, Huangqi-Guizhi-Wuwu Decoction, Shentong-Zhuyu Decoction

CLC Number:

R730.6

LI Yuan-qing, SUN Hong, XUE Dong, LI Zhan-dong, XU Yi-chen, WANG Wei, LI Ping-ping. Effects of Chinese Medicine on Chemotherapy-induced Peripheral Neuropathy: A Randomized, Double-blind, Placebo-controlled Clinical Trial[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2017, 23(11): 1321-1325.

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Effects of Chinese Medicine on Chemotherapy-induced Peripheral Neuropathy: A Randomized, Double-blind, Placebo-controlled Clinical Trial

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