神经肽Y受体系统参与痛觉调制的研究进展

doi:10.3969/j.issn.1006-9771.2018.00.006

Abstract

Abstract: The neuropeptide Y receptors system is a receptor-ligand system composed of neuropeptide Y and its receptors, which is represented by two subtypes, including Y1 receptor (Y1R) and Y2 receptor (Y2R). The system is widely involved in pain modulation in mammals. These receptors are G protein-coupled receptors, participating in neuronal membrane signaling. Neuropeptide Y receptors distribute in the pain-related regions of the central nervous system, play a variety of roles in maintains neuronal activity of pain transmission, relate to the specificity of distribution. At the spinal level, Y1R plays an analgesic role, whereas Y2R is usually related to pain-promoting. The system can also take part in cerebral pain modulation at different nuclei.

Key words: neuropeptide Y, receptors, pain modulation, review

CLC Number:

R741.02

ZHAO Shu-xuan, ZHANG Dong-liang, SHEN Wei, FENG Xiao-fei, LIU Zheng, YUAN Wen-hua, ZHOU Hai-yu. Advance in Role of Neuropeptide Y Receptors System in Pain Modulation (review)[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2018, 24(11): 1284-1287.

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Advance in Role of Neuropeptide Y Receptors System in Pain Modulation (review)

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