《Chinese Journal of Rehabilitation Theory and Practice》 ›› 2018, Vol. 24 ›› Issue (1): 80-83.doi: 10.3969/j.issn.1006-9771.2018.01.015

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Advance in Model Establishment for Denervated Skeletal Muscle Atrophy (review)

ZHAO Dan-dan, TANG Cheng-lin, HUANG Si-qin, LUO Ao, ZHANG An-ning, AN Hui-yu, WU Meng-jia, TAN Cheng-fang   

  1. 1. College of Traditional Chinese Medicine, Chongqing Medical University, Chongqing 400016, China
    2. Chongqing Key Laboratory of Traditional Chinese Medicine for Prevention and Cure of Metabolic Diseases, Chongqing 400016, China
  • Received:2017-09-25 Revised:2017-11-25 Published:2018-01-25 Online:2018-01-31
  • Contact: TANG Cheng-lin.E-mail:cytcl996@163.com
  • Supported by:
    National Natural Science Foundation of China (No. 81273870)

Abstract: The skeletal muscle atrophy could be induced by the injury of nerve. According to the source of denervated skeletal muscle atrophy, it could be divided into exogenous muscle atrophy and endogenous muscle atrophy. In recent years, the exogenous muscle atrophy models are mainly established by operating, physically injuring or chemically injuring, while the endogenous muscle atrophy models are mainly established by the transgenic animals of amyotrophic lateral sclerosis. The selection and optimazation of animal models are crucial for the basic studies of denervated skeletal muscle atrophy.

Key words: denervated skeletal muscle atrophy, animal model, establishment, review

CLC Number: