低氧预处理与高氧预处理在脊髓损伤后神经保护作用的相关研究进展

doi:10.3969/j.issn.1006-9771.2018.01.017

Abstract

Abstract: Repeated acute intermittent hypoxia promotes the expression of growth factors and neurotrophic factors, as well as the key molecules for neural protection and plasticity. Hypoxic preconditioning may improve the survival rate of transplanted stem cells and protect the neural function. Meanwhile, acute intermittent hypoxia can be an approach to improve respiratory function after spinal cord injury. Hyperbaric oxygen may improve the neural tolerance to hypoxia and ischemia, to protect the structure of cells and tissues, and promote the neuranagenesis. It is important to study the role of hypoxic and hyperoxic preconditioning in spinal cord injury.

Key words: spinal cord injury, preconditioning, hypoxia, hyperoxia, vascular endothelial growth factor, hypoxia inducible factor-1, stem cells, review

CLC Number:

R651.2

ZHANG Wen-xiu, ZHANG Yan, ZHANG Yan-jun, WU Qi-chao, LIU Ya-dong, LIU Zong-jian, GUAN Yun, CHEN Xue-ming. Research Related to Neural Protection of Hypoxic and Hyperoxic Preconditioning after Spinal Cord Injury (review)[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2018, 24(1): 90-92.

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Research Related to Neural Protection of Hypoxic and Hyperoxic Preconditioning after Spinal Cord Injury (review)

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