《Chinese Journal of Rehabilitation Theory and Practice》 ›› 2018, Vol. 24 ›› Issue (2): 160-164.doi: 10.3969/j.issn.1006-9771.2018.02.008

• CONTENTS • Previous Articles     Next Articles

Neurobiological Effect of Brain-derived Neurotrophic Factor after Spinal Cord Injury (review)

LI Xiang-zhe1, 2, WANG Can3, WU Qin-feng1, 2, WANG Tong4   

  1. 1. Rehabilitation Medicine Center of Suzhou Science & Technology Town Hospital, Suzhou, Jiangsu 215153, China;;
    2. Rehabilitation Medicine Center of Suzhou Hospital Affiliated to Nanjing Medical University, Suzhou, Jiangsu 215153, China;
    3. Children's Development Center of Suzhou Municipal Hospital, Suzhou, Jiangsu 215008, China;
    4. Rehabilitation Center of Jiangsu Provincial People's Hospital, Nanjing, Jiangsu 210029, China
  • Received:2017-11-30 Revised:2018-01-01 Published:2018-02-25 Online:2018-03-02
  • Contact: WU Qin-feng. E-mail:wuqinfeng0911@163.com
  • Supported by:
    ; Supported by National Natural Science Foundation of China (General) (No. 81672258) and Livelihood Science and Technology Program of Suzhou Science and Technology Bureau (No. SYS201785)

Abstract: Spinal cord injury (SCI) can lead to varying degrees of somatic and autonomic dysfunction and seriously affect the quality of life of patients. The neurobiology and function promotion effects of brain-derived neurotrophic factor (BDNF) after SCI have been extensively studied, including neuroprotection, neuroplasticity and process regulation of neuroinflammation, etc., as well as functional recovery. However, the adverse effects of BDNF after SCI, such as neuropathic pain and spasticity, were also studied.

Key words: spinal cord injury, brain-derived neurotrophic factor, neural repair, spasticity, neuropathic pain, review

CLC Number: