大鼠脊髓损伤后胃肠动力的X线研究

doi:10.3969/j.issn.1006-9771.2018.06.005

Abstract

Abstract: Objective To study the dynamic changes of the intestinal function of neurogenic bowel dysfunction rats caused by spinal cord injury using X-ray radiography.Methods Twenty-four female Sprague-Dawley rats were divided into control group (n=12) and spinal cord injury group (n=12). The T₁₀ spinal cord injury model was established using aneurysm clip (70 grams calibration force) for 60 seconds. The control group exposed the dura only. X-ray Barium was used to observe the dynamic changes of intestinal function, and HE staining was used to observe the pathology of the colon before and four weeks after modeling.Results Compared with the control group, gastric emptying and intestinal transit function significantly reduced in the spinal cord injury group (P<0.05).Conclusion The spinal cord injury model can be successfully duplicated with aneurysm clip in rats; neurogenic bowel dysfunction occurs after spinal cord injury, gastric emptying and intestinal transit function are weakened.

Key words: spinal cord injury, neurogenic bowel dysfunction, X-ray, rats

CLC Number:

R651.2

CAI Chang, LI Jian-jun, GAO Feng, YANG Ming-liang, DU Liang-jie, YANG De-gang, LIU Chang-bin, LI Da-peng, ZHANG Wen-hao, XU Pei-pei. Gastrointestinal Motility after Spinal Cord Injury in Rats: An X-ray Study[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2018, 24(6): 645-649.

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Gastrointestinal Motility after Spinal Cord Injury in Rats: An X-ray Study

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