利鲁唑治疗脊髓损伤的研究进展

doi:10.3969/j.issn.1006-9771.2018.06.006

Abstract

Abstract: Spinal cord injury (SCI) is a disabling disease usually caused by trauma. The treatment and nursing of SCI patients has brought great economic burden to the society. This article introduced the mechanism of riluzole in treating spinal cord injury, including blocking Na⁺ channels, reducing glutamate-mediated excitotoxicity, promoting the expression of neurotrophic factors, and alleviating cellular oxidative stress damage and apoptosis, and the research progress on clinical trials of riluzole.

Key words: spinal cord injury, riluzole, neuroprotection, amyotrophic lateral sclerosis, review

CLC Number:

R651.2

WU Qi-chao, ZHANG Yan, ZHANG Wen-xiu, ZHANG Yan-jun, LIU Ya-dong, ZHAO Ying-lun, LIU Zong-jian, CHEN Xue-ming. Advance in Riluzole for Spinal Cord Injury (review)[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2018, 24(6): 650-653.

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Advance in Riluzole for Spinal Cord Injury (review)

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