特发性震颤与特发性震颤发展成帕金森病患者的临床特征比较

doi:10.3969/j.issn.1006-9771.2018.07.002

《Chinese Journal of Rehabilitation Theory and Practice》 ›› 2018, Vol. 24 ›› Issue (7): 757-762.doi: 10.3969/j.issn.1006-9771.2018.07.002

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Features of Essential Tremor and Parkinson's Disease Developed from Essential Tremor

WANG Xue-mei, CAO Zhen-tang, LIU Zhu, MA Hui-zi, WANG Zhan, YANG Ya-qin, FENG Tao

1. Center for Neurodegenerative Disease, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China;
2. China National Clinical Research Center for Neurological Disease, Beijing 100050, China;
3. Parkinson's Disease Center, Beijing Institute for Brain Disorder, Capital Medical University, Beijing 100050, China

Received:2018-05-22 Revised:2018-06-08 Published:2018-07-25 Online:2018-08-01
Contact: FENG Tao. E-mail: happyft@sina.com
Supported by:
Supported by National Natural Science Foundation of China (General) (No. 81571226 and No. 81771367), Capital Clinical Application Research Program (No. Z171100001017041), Beijing Science and Technology Commission Fund (No. Z151100003915150) and National Key Research and Development Program of the 13th Five-Year Plan (No. 2016YFC1306501)

Abstract

Abstract: Objective To compare the characteristics of tremor and non-motor symptoms in patients with essential tremor (ET) and patients with Parkinson's disease developed from essential tremor (ET-PD). Methods From March, 2016 to August, 2017, 30 ET patients and 17 ET-PD patients were investigated with the general questionnaire, Hamilton Depression Scale (HAMD), Hamilton Anxiety Scale (HAMA), Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA), and were measured with transcranial sonography and the frequency, amplitude and contraction patterns of resting and postural tremors. Results Compared with the ET patients, there were more patients reported olfactory dysfunction and rapid eye movement behavior disorder (RBD) in ET-PD patients (χ²>4.656, P<0.05). Meanwhile, the area of hyperechogenicity in substantia nigra was greater (t=2.164, P<0.05), the incidence of lower limb tremor and mandibular tremor was more (χ²>8.745, P<0.01), the frequency of rest and postural tremor in the head and upper limbs was less (t>2.082, P<0.05). The rest and postural tremors in the upper limbs were mainly synchronous in ET patients, whereas it was alternating in ET-PD patients (χ²>3.943, P<0.05). Conclusion Some differences of non-motor symptoms and tremor are found in patients with ET-PD and ET. When ET patients suffer from hyposmia, RBD, or the site, frequency and contraction patterns of tremor changes, they may develop to PD.

Key words: essential tremor, Parkinson's disease, non-motor symptoms, tremor, tremor analysis

CLC Number:

R742.5

WANG Xue-mei, CAO Zhen-tang, LIU Zhu, MA Hui-zi, WANG Zhan, YANG Ya-qin, FENG Tao. Features of Essential Tremor and Parkinson's Disease Developed from Essential Tremor[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2018, 24(7): 757-762.

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Features of Essential Tremor and Parkinson's Disease Developed from Essential Tremor

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