《Chinese Journal of Rehabilitation Theory and Practice》 ›› 2018, Vol. 24 ›› Issue (8): 880-883.doi: 10.3969/j.issn.1006-9771.2018.08.002

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Advance in Localization of Brain Injury for Post-stroke Anomic Aphasia (review)

YE Na, ZHANG Yu-mei   

  1. 1. Department of Cerebral Vascular Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China;
    2. China National Clinical Research Center for Neurological Diseases, Beijing 100050, China;
    3. Beijing Institute for Brain Disorders, Beijing 100050, China;
    4. Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing 100050, China
  • Received:2018-03-29 Revised:2018-05-10 Published:2018-08-25 Online:2018-08-20
  • Contact: ZHANG Yu-mei. E-mail: zhangyumei95@aliyun.com
  • Supported by:
    Supported by Beijing Municipal Administration of Hospitals Sail Plan (Key) (No. ZYLX201836), National Natural Science Foundation of China (General) (No. 81371201) and Capital Medical University Research Project for Basic and Clinical Cooperation (Key) (No. 16JL03)

Abstract: The most important characteristic of post-stroke anomic aphasia is disorder in nomenclature, but the location of brain injury has been unclear. In recent years, it was found that, based on T1WI of MRI, the location is uncertain in chronic anomic aphasia after stroke, but it is mostly in temporal lobe of the dominant hemisphere in acute stage. Based on diffusion tensor imaging, the subcortical white matter, especially the left subfrontal white matter plays an important role in the naming process. The fMRI studies found that anomic aphasia is related to the destruction of the connections among some specific gray matter brain regions, named brain network theory. The cognitive psychology theory suggested that language processing can be further divided into different steps, each step is responsible for different brain regions; for different kinds of words, such as verbs and nouns, the processing involves different regions.

Key words: anomic aphasia, post-stroke aphasia, subcortical white matter, brain network, picture naming, review

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