Rab27a基因与外泌体的研究进展

doi:10.3969/j.issn.1006-9771.2018.10.008

Abstract

Abstract: Rab27a gene can participate in the secretion, transportation and exocytosis of T lymphocytes, mast cells, neutrophils, pancreatic β cells and hematopoietic cells through its encoded proteins, and participate in the development of diseases such as albinism, cancer, diabetes, inflammation and thrombosis. In addition, the secretion regulation of Rab27a to exosomes has also received much attention. The current research status of the secretion of exosome and the genetically modified exosomes of Rab27a gene in the treatment of diseases such as inflammatory injury, thrombosis and tumor were reviewed.

Key words: Rab27a gene, exosomes, inflammation, tumor, review

CLC Number:

R363

WANG Xiao-xia, CHEN Yu-sen, MA Xiao-tang, PAN Qun-wen, HUANG Zi-hui. Advance of Rab27a Gene and Exosomes (review)[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2018, 24(10): 1159-1164.

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Advance of Rab27a Gene and Exosomes (review)

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