《Chinese Journal of Rehabilitation Theory and Practice》 ›› 2019, Vol. 25 ›› Issue (2): 196-200.doi: 10.3969/j.issn.1006-9771.2019.02.012

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Synaptic Plasticity Regulation of Nogo-A and Development of Related Neurological Diseases (review)

HE Mei1, 2, MAO Min1, ZHAO Guo-yan1, TANG Jun-jie1, FENG Shuang1, LU Xiu-min1, WANG Yong-tang2   

  1. 1. College of Pharmacy and Biological Engineering, Chongqing University of Technology, Chongqing 400054, China
    2. State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing 400042, China
  • Received:2018-10-01 Revised:2018-10-18 Published:2019-02-25 Online:2019-04-01
  • Contact: LU Xiu-min, WANG Yong-tang. E-mail: luxm@cqut.edu.cn (LU Xiu-min); wangytlu@163.com(WANG Yong-tang)
  • Supported by:
    National Natural Science Foundation of China (No. 81671903; No. 81772064; No. 81372040),

Abstract: Axonal damage leads to permanent defects in the adult mammals central nervous system. As an important axonal growth inhibitor, Nogo-A and its receptors involve in the regulation of synaptic plasticity in mature neurons of the central nervous system, and play a role in the related neurological diseases, such as spinal cord injury, multiple sclerosis, Alzheimer's disease and posttraumatic stress disorder.

Key words: Nogo-A, Nogo-A receptors, synaptic plasticity, nervous system disease, review

CLC Number: