运动诱导细胞自噬在老年肌少症康复中的研究进展

doi:10.3969/j.issn.1006-9771.2019.03.015

Abstract

Abstract: arcopenia is an aging-related disease with a significant reduction in mass and strength of skeletal muscle due to the imbalance between protein synthesis and degradation. Autophagy acts as a conserved mechanism regulating the balance of protein metabolism in body and can be regulated by multiple signaling pathways such as AMP-activated protein kinase (AMPK), insulin like growth factor (IGF)/ protein kinase B (Akt)/ mammalian target of rapamycin (mTOR) and phosphatidylinositol 3 kinase (PI3K)/Akt/mTOR induced by exercise. Exercise-activated autophagy regulates skeletal muscle remodeling and homeostasis under different physiological and pathological conditions, which is the key to skeletal muscle health maintenance. This article reviewed the regulator roles and potential molecular mechanisms of varying exercise-induced autophagy in the prevention, treatment and rehabilitation of sarcopenia.

Key words: sarcopenia, autophagy, exercise intervention, signal pathway, review

CLC Number:

R746.4

LIANG Ji-ling, XIE Jin-feng, WANG Cen-yi, CHEN Ning. Regulatory Role of Exercise-induced Autophagy in Rehabilitation of Sarcopenia (review)[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2019, 25(3): 334-337.

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Regulatory Role of Exercise-induced Autophagy in Rehabilitation of Sarcopenia (review)

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