《Chinese Journal of Rehabilitation Theory and Practice》 ›› 2019, Vol. 25 ›› Issue (5): 553-556.doi: 10.3969/j.issn.1006-9771.2019.05.010

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Association between Ser9Gly Polymorphism of DRD3 Gene and Depression in Parkinson's Disease

MA Ling-yan1, MA Hui-zi1, FENG Tao1,2,3   

  1. 1.Center of Movement Disorder, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China
    2.China National Clinical Research Center for Neurological Disease, Beijing 100070, China
    3.Parkinson's Disease Center, Beijing Institute for Brain Disorder, Beijing 100070, China
  • Received:2018-10-17 Revised:2018-12-10 Published:2019-05-25 Online:2019-05-29
  • Contact: FENG Tao, E-mail: happyft@sina.com
  • Supported by:
    Beijing Natural Science Foundation (No. 7164254), National Natural Science Foundation of China (General) (No. 81571226; No. 81771367), Capital Clinical Application Research Program (No. Z171100001017041), Beijing Science and Technology Commission Fund (No. Z151100003915150) and National Key Research and Development Program (No. 2016YFC1306501)

Abstract: Objectives To explore the relationship between the dopamine D3 receptor (DRD3) polymorphism on Ser9Gly and depression in Parkinson's disease (PD).Methods From June, 2016 to June, 2018, 312 Chinese patients with PD were divided into depression group (n = 132) and non-depression group (n = 180) according to scores of Hamilton Depression Scale. A total of 252 age- and gender-matched healthy subjects were recruited as control group. Their blood samples were collected. Genotyping of Ser9Gly polymorphism was carried out using polymerase chain reaction-restriction fragment length polymorphism. Results No statistical difference was identified in Ser9Gly polymorphism among three groups in both gene types and allel (χ2 = 3.095, χ2 = 2.627, P > 0.05). Conclusion Ser9Gly polymorphism in DRD3 gene may not be a susceptible factor for depression in PD in China.

Key words: Parkinson's disease, depression, DRD3, Ser9Gly, polymorphism

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