《Chinese Journal of Rehabilitation Theory and Practice》 ›› 2019, Vol. 25 ›› Issue (6): 630-633.doi: 10.3969/j.issn.1006-9771.2019.06.002

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Role and Mechanism of Ski in Glial Scar Formation post Spinal Cord Injury (review)

XIANG Gao1,2, LIU Kai-xin1,2, GONG Chao-yang1,2, YANG Liang1,2, ZHANG Hai-hong1   

  1. 1.Department of Orthopedics, the Second Clinical Medical College of Lanzhou University, Lanzhou, Gansu 730030, China;
    2.Lanzhou University Key Laboratory of Orthopedics of Gansu Province, Lanzhou, Gansu 730030, China
  • Received:2018-12-04 Revised:2019-03-16 Online:2019-06-25
  • Contact: ZHANG Hai-hong, E-mail: zhanghaihong1968@sina.com
  • Supported by:
    Gansu Natural Science Foundation (No. 17JR5RA238) and the Second Hospital of Lanzhou University Funding (No. CY2017-MS06)

Abstract: Ski is an evolutionary conserved protein, which is involved in diverse cellular processes such as proliferation, differentiation, transformation and tumor progression. In spinal cord injury, the activation of astrocytes and reactive astrocyte hyperplasia are important factors affecting the formation of glial scar after spinal cord injury. Ski is highly expressed after spinal cord injury, and acts on astrocytes through transforming growth factor-beta, mitogen-activated protein kinase and other signaling pathways, and regulates their activation, proliferation, migration and glial scar formation, providing a new therapeutic direction for the treatment of spinal cord injury.

Key words: spinal cord injury, glial scar, Ski, mechanism, review

CLC Number: