《Chinese Journal of Rehabilitation Theory and Practice》 ›› 2019, Vol. 25 ›› Issue (6): 634-637.doi: 10.3969/j.issn.1006-9771.2019.06.003

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Advance in Role of IκB Kinase beta in Inflammatory Response Mechanism post Spinal Cord Injury (review)

TANG Rui-ling1,2, LI Min1,2, WANG Jun-yu1,2, XIANG Wu1,2, ZHANG An-ren2   

  1. 1.Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610037, China;
    2.Department of Rehabilitation Medicine, the General Hospital of Western Theater Command, Chengdu, Sichuan 610083, China
  • Received:2019-04-15 Revised:2019-05-16 Online:2019-06-25
  • Contact: ZHANG An-ren, E-mail: 1518526780@qq.com
  • Supported by:
    National Natural Science Foundation of China (General) (No. 81674044)

Abstract: IκB kinase beta (IKKbeta) is a key kinase in nuclear factor kappa B (NF-kappaB) signaling pathway. After spinal cord injury, IKKbeta is activated, and the signal pathway of NF-kappa B is abnormally activated, which produces a large number of inflammatory factors, which has a negative impact on the recovery of spinal cord injury. This article mainly summarized the structure and function of IKKbeta and its application in inflammatory reaction after spinal cord injury, trying to find a new target for the treatment of spinal cord injury.

Key words: IκB kinase beta, spinal cord injury, inflammatory response, nuclear factor kappa B, review

CLC Number: