5-羟色胺再摄取抑制剂在缺血性脑卒中中的应用及机制研究进展

doi:10.3969/j.issn.1006-9771.2019.07.007

Abstract

Abstract: Serotonin selective reuptake inhibitors (SSRIs) have been widely used for post-stroke depression. Recently, SSRIs are considered as an effective drug to improve motor function after stroke. Mechanism of SSRIs improving motor function after ischemic stroke involves extensive factors, and there is no definitive conclusion yet. While, the effects of SSRIs on motor function after stroke remains debatable. Besides, there are potential risks of SSRIs in the treatment of stroke. It is necessary to evaluate the benefits and risks of SSRIs for patients with ischemic stroke.

Key words: ischemic stroke, serotonin selective reuptake inhibitors, motor function, review

CLC Number:

R743.3

LI Ce, ZHANG Bei, BAI Yu-long. Advance in Clinial and Mechanism Reseaches about Serotonin Selective Reuptake Inhibitors for Ischemic Stroke (review)[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2019, 25(7): 778-782.

References

1 de KeyserJ, SulterG, LuitenP G. Clinical trials with neuroprotective drugs in acute ischaemic stroke: are we doing the right thing? [J]. Trends Neurosci, 1999, 22(12): 535-540.
2 ChenH F, PanX L, WangJ W, et al. Protein-drug interactome analysis of SSRI-mediated neurorecovery following stroke [J]. Biosystems, 2014, 120: 1-9.
3 RueterL E, FornalC A, JacobsB L. A critical review of 5-HT brain microdialysis and behavior [J]. Rev Neurosci, 1997, 8(2): 117-137.
4 MostertJ P, KochM W, HeeringsM, et al. Therapeutic potential of fluoxetine in neurological disorders [J]. Cns Neurosci Ther, 2008, 14(2): 153-164.
5 HackettM L, PicklesK. Part I: frequency of depression after stroke: an updated systematic review and meta-analysis of observational studies [J]. Int J Stroke, 2014, 9(8): 1017-1025.
6 FlasterM, SharmaA, RaoM. Poststroke depression: a review emphasizing the role of prophylactic treatment and synergy with treatment for motor recovery [J]. Top Stroke Rehabil, 2013, 20(2): 139-150.
7 ParienteJ, LoubinouxI, CarelC, et al. Fluoxetine modulates motor performance and cerebral activation of patients recovering from stroke [J]. Ann Neurol, 2001, 50(6): 718-729.
8 PaolucciS, AntonucciG, GrassoM G, et al. Post-stroke depression, antidepressant treatment and rehabilitation results. A case-control study [J]. Cerebrovasc Dis, 2001, 12(3): 264-271.
9 CholletF, TardyJ, AlbucherJ F, et al. Fluoxetine for motor recovery after acute ischaemic stroke (FLAME): a randomised placebo-controlled trial [J]. Lancet Neurol, 2011, 10(2): 123-130.
10 MeadG E, HsiehC F, LeeR, et al. Selective serotonin reuptake inhibitors (SSRIs) for stroke recovery [J]. Cochrane Database Syst Rev, 2012, 11: CD009286.
11 RobinsonR G, SchultzS K, CastilloC, et al. Nortriptyline versus fluoxetine in the treatment of depression and in short-term recovery after stroke: a placebo-controlled, double-blind study [J]. Am J Psychiatry, 2000, 157(3): 351-359.
12 PlegerB, SchwenkreisP, GrunbergC, et al. Fluoxetine facilitates use-dependent excitability of human primary motor cortex [J]. Clin Neurophysiol, 2004, 115(9): 2157-2163.
13 NannettiL, PaciM, PasquiniJ, et al. Motor and functional recovery in patients with post-stroke depression [J]. Disabil Rehabil, 2005, 27(4): 170-175.
14 GonzenbachR R, TaegtmeyerA B, LuftA, et al. Fluoxetine and motor recovery after ischaemic stroke [J]. Lancet Neurol, 2011, 10(6): 499-500.
15 ShinT K, KangM S, LeeH Y, et al. Fluoxetine and sertraline attenuate postischemic brain injury in mice [J]. Korean J Physiol Pharmacol, 2009, 13(3): 257-263.
16 LimC M, KimS W, ParkJ Y, et al. Fluoxetine affords robust neuroprotection in the postischemic brain via its anti-inflammatory effect [J]. J Neurosci Res, 2009, 87(4): 1037-1045.
17 NgK L, GibsonE M, HubbardR, et al. Fluoxetine maintains a state of heightened responsiveness to motor training early after stroke in a mouse model [J]. Stroke, 2015, 46(10): 2951-2960.
18 ZhuB G, SunY, SunZ Q, et al. Optimal dosages of fluoxetine in the treatment of hypoxic brain injury induced by 3-nitropropionic acid: implications for the adjunctive treatment of patients after acute ischemic stroke [J]. CNS Neurosci Ther, 2012, 18(7): 530-535.
19 LoubinouxI, TombariD, ParienteJ, et al. Modulation of behavior and cortical motor activity in healthy subjects by a chronic administration of a serotonin enhancer [J]. Neuroimage, 2005, 27(2): 299-313.
20 Gerdelat-MasA, LoubinouxI, TombariD, et al. Chronic administration of selective serotonin reuptake inhibitor (SSRI) paroxetine modulates human motor cortex excitability in healthy subjects [J]. Neuroimage, 2005, 27(2): 314-322.
21 BerendsH I, NijlantJ, van PuttenM, et al. Single dose of fluoxetine increases muscle activation in chronic stroke patients [J]. Clin Neuropharmacol, 2009, 32(1): 1-5.
22 QiaoJ, WangJ, WangH, et al. Regulation of astrocyte pathology by fluoxetine prevents the deterioration of Alzheimer phenotypes in an APP/PS1 mouse model [J]. Glia, 2016, 64(2): 240-254.
23 ShanH, BianY, ShuZ, et al. Fluoxetine protects against IL-1beta-induced neuronal apoptosis via downregulation of p53 [J]. Neuropharmacology, 2016, 107: 68-78.
24 SiepmannT, PenzlinA I, KepplingerJ, et al. Selective serotonin reuptake inhibitors to improve outcome in acute ischemic stroke: possible mechanisms and clinical evidence [J]. Brain Behav, 2015, 5(10): e00373.
25 TiradentesR V, PiresJ G, SilvaN F, et al. Effects of acute administration of selective serotonin reuptake inhibitors on sympathetic nerve activity [J]. Braz J Med Biol Res, 2014, 47(7): 554-559.
26 GreeneJ, BanasrM, LeeB, et al. Vascular endothelial growth factor signaling is required for the behavioral actions of antidepressant treatment: pharmacological and cellular characterization [J]. Neuropsychopharmacology, 2009, 34(11): 2459-2468.
27 TakebayashiM, HashimotoR, HisaokaK, et al. Plasma levels of vascular endothelial growth factor and fibroblast growth factor 2 in patients with major depressive disorders [J]. J Neural Transm (Vienna), 2010, 117(9): 1119-1122.
28 SchmidtH D, DumanR S. The role of neurotrophic factors in adult hippocampal neurogenesis, antidepressant treatments and animal models of depressive-like behavior [J]. Behav Pharmacol, 2007, 18(5-6): 391-418.
29 DempseyR J, SailorK A, BowenK K, et al. Stroke-induced progenitor cell proliferation in adult spontaneously hypertensive rat brain: effect of exogenous IGF-1 and GDNF [J]. J Neurochem, 2003, 87(3): 586-597.
30 WiltroutC, LangB, YanY, et al. Repairing brain after stroke: a review on post-ischemic neurogenesis [J]. Neurochem Int, 2007, 50(7-8): 1028-1041.
31 TiraboschiE, TarditoD, KasaharaJ, et al. Selective phosphorylation of nuclear CREB by fluoxetine is linked to activation of CaM kinase IV and MAP kinase cascades [J]. Neuropsychopharmacology, 2004, 29(10): 1831-1840.
32 LonzeB E, GintyD D. Function and regulation of CREB family transcription factors in the nervous system [J]. Neuron, 2002, 35(4): 605-623.
33 MercierG, LennonA M, RenoufB, et al. MAP kinase activation by fluoxetine and its relation to gene expression in cultured rat astrocytes [J]. J Mol Neurosci, 2004, 24(2): 207-216.
34 RiefW, BarskyA J, BingelU, et al. Rethinking psychopharmacotherapy: the role of treatment context and brain plasticity in antidepressant and antipsychotic interventions [J]. Neurosci Biobehav Rev, 2016, 60: 51-64.
35 OfekK, SchoknechtK, Melamed-BookN, et al. Fluoxetine induces vasodilatation of cerebral arterioles by co-modulating NO/muscarinic signalling [J]. J Cell Mol Med, 2012, 16(11): 2736-2744.
36 KhodanovichM, KiselA, KudabaevaM, et al. Effects of fluoxetine on hippocampal neurogenesis and neuroprotection in the model of global cerebral ischemia in rats [J]. Int J Mol Sci, 2018. DOI： info:doi/10.3390/ijms19010162.
37 SinghD P, ChopraK. Flavocoxid, dual inhibitor of cyclooxygenase-2 and 5-lipoxygenase, exhibits neuroprotection in rat model of ischaemic stroke [J]. Pharmacol Biochem Behav, 2014, 120: 33-42.
38 DhamiK S, ChurchwardM A, BakerG B, et al. Fluoxetine and citalopram decrease microglial release of glutamate and D-serine to promote cortical neuronal viability following ischemic insult [J]. Mol Cell Neurosci, 2013, 56: 365-374.
39 LiW L, CaiH H, WangB, et al. Chronic fluoxetine treatment improves ischemia-induced spatial cognitive deficits through increasing hippocampal neurogenesis after stroke [J]. J Neurosci Res, 2009, 87(1): 112-122.
40 ArvidssonA, CollinT, KirikD, et al. Neuronal replacement from endogenous precursors in the adult brain after stroke [J]. Nat Med, 2002, 8(9): 963-970.
41 VaswaniM, LindaF K, RameshS. Role of selective serotonin reuptake inhibitors in psychiatric disorders: a comprehensive review [J]. Prog Neuropsychopharmacol Biol Psychiatry, 2003, 27(1): 85-102.
42 SunX, SunX, LiuT, et al. Fluoxetine enhanced neurogenesis is not translated to functional outcome in stroke rats [J]. Neurosci Lett, 2015, 603: 31-36.
43 OhabJ J, FlemingS, BleschA, et al. A neurovascular niche for neurogenesis after stroke [J]. J Neurosci, 2006, 26(50): 13007-13016.
44 SunY, SunX, QuH, et al. Neuroplasticity and behavioral effects of fluoxetine after experimental stroke [J]. Restor Neurol Neurosci, 2017, 35(5): 457-468.
45 CorbettA M, SieberS, WyattN, et al. Increasing neurogenesis with fluoxetine, simvastatin and ascorbic acid leads to functional recovery in ischemic stroke [J]. Recent Pat Drug Deliv Formul, 2015, 9(2): 158-166.
46 PengL, GuL, LiB, et al. Fluoxetine and all other SSRIs are 5-HT2B agonists － Importance for their therapeutic effects　[J]. Curr Neuropharmacol, 2014, 12(4): 365-379.
47 HertzL, RothmanD L, LiB, et al. Chronic SSRI stimulation of astrocytic 5-HT2B receptors change multiple gene expressions/editings and metabolism of glutamate, glucose and glycogen: a potential paradigm shift [J]. Front Behav Neurosci, 2015, 9: 25.
48 DiazS L, Narboux-NemeN, BoutourlinskyK, et al. Mice lacking the serotonin 5-HT2B receptor as an animal model of resistance to selective serotonin reuptake inhibitors antidepressants [J]. Eur Neuropsychopharmacol, 2016, 26(2): 265-279.
49 WindleV, CorbettD. Fluoxetine and recovery of motor function after focal ischemia in rats [J]. Brain Res, 2005, 1044(1): 25-32.
50 ZhaoC S, PuurunenK, SchallertT, et al. Behavioral and histological effects of chronic antipsychotic and antidepressant drug treatment in aged rats with focal ischemic brain injury [J]. Behav Brain Res, 2005, 158(2): 211-220.
51 WangM T, ChuC L, YehC B, et al. Antidepressant use and risk of recurrent stroke: a population-based nested case-control study [J]. J Clin Psychiatry, 2015, 76(7): e877-e885.
52 HeY, CaiZ, ZengS, et al. Effect of fluoxetine on three-year recurrence in acute ischemic stroke: a randomized controlled clinical study [J]. Clin Neurol Neurosurg, 2018, 168: 1-6.
53 MortensenJ K, LarssonH, JohnsenS P, et al. Post stroke use of selective serotonin reuptake inhibitors and clinical outcome among patients with ischemic stroke: a nationwide propensity score-matched follow-up study [J]. Stroke, 2013, 44(2): 420-426.
54 PintoC B, Saleh VelezF G, LopesF, et al. SSRI and motor recovery in stroke: reestablishment of inhibitory neural network tonus [J]. Front Neurosci, 2017, 11: 637.
55 AlperK, SchwartzK A, KoltsR L, et al. Seizure incidence in psychopharmacological clinical trials: an analysis of Food and Drug Administration (FDA) summary basis of approval reports [J]. Biol Psychiatry, 2007, 62(4): 345-354.
56 LiepertJ. Update on pharmacotherapy for stroke and traumatic brain injury recovery during rehabilitation [J]. Curr Opin Neurol, 2016, 29(6): 700-705.
57 FoltinR W, HaneyM, ComerS D, et al. Effect of fluoxetine on food intake of humans living in a residential laboratory [J]. Appetite, 1996, 27(2): 165-181.
58 RieckmannN, KronishI M, ShapiroP A, et al. Serotonin reuptake inhibitor use, depression, and long-term outcomes after an acute coronary syndrome: a prospective cohort study [J]. JAMA Intern Med, 2013, 173(12): 1150-1151.
59 GrahamC, LewisS, ForbesJ, et al. The FOCUS, AFFINITY and EFFECTS trials studying the effect(s) of fluoxetine in patients with a recent stroke: statistical and health economic analysis plan for the trials and for the individual patient data meta-analysis [J]. Trials, 2017, 18(1): 627.

[1]	SHAO Weiting, LEI Jianghua. Effect of response interruption and redirection as a behavioral intervention on vocal stereotypy in children with autism spectrum disorder: a scoping review [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2024, 30(1): 10-20.
[2]	WANG Hangyu, GE Keke, FAN Yonghong, DU Lilu, ZOU Min, FENG Lei. Effect of active music therapy on cognitive function for older adults with cognitive impairment: a systematic review based on ICD-11 and ICF [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2024, 30(1): 36-43.
[3]	WEN Jianing, JIN Qiuyan, ZHANG Qi, LI Jie, SI Qi. Effect of cognitively engaging physical activity on developing executive function of children and adolescents: a systematic review based on ICF [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2024, 30(1): 44-53.
[4]	GE Keke, FAN Yonghong, WANG Hangyu, DU Lilu, LI Changjiang, ZOU Min. Health benefit of mindfulness intervention for older adults with insomnia disorders: a systematic review [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2024, 30(1): 54-60.
[5]	CHEN Junwen, CHEN Qian, CHEN Cheng, LI Shuyue, LIU Lingling, WU Cunshu, GONG Xiang, LU Jun, XU Guangxu. Effect of modified Baduanjin exercise on cardiopulmonary function, motor function and activities of daily living for stroke patients [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2024, 30(1): 74-80.
[6]	ZHANG Jingya, ZOU Min, SUN Hongwei, SUN Changlong, ZHU Juntong. Effect of psychological intervention on anxiety or depression in children and adolescents with hearing impairment: a systematic review [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2023, 29(9): 1004-1011.
[7]	WANG Junyu, YANG Yong, YUAN Xun, XIE Ting, ZHUANG Jie. Effect of high-intensity interval training on executive function for healthy children and adolescents: a systematic review [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2023, 29(9): 1012-1020.
[8]	WEI Xiaowei, YANG Jian, WEI Chunyan. Psychological and behavioral benefits of adapted yoga exercise for children with autism spectrum disorder in special education schools: a systematic review [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2023, 29(9): 1021-1028.
[9]	YANG Yaru, YANG Jian. School-based physical activity-related health services and their health benefits within the World Health Organization health-promoting school framework: a systematic review of systematic reviews [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2023, 29(9): 1040-1047.
[10]	WANG He, HAN Liang, KAN Mengfan, YU Shaohong. Efficacy of electrical stimulation on shoulder-hand syndrome after stroke: a systematic review and meta-analysis [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2023, 29(9): 1048-1056.
[11]	SHI Jiawei, LI Lingyu, YANG Haojie, WANG Qinlu, ZOU Haiou. Effect of preoperative prerehabilitation training on total knee arthroplasty: a systematic review of systematic reviews [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2023, 29(9): 1057-1064.
[12]	SUN Tengfang, REN Mengting, YANG Lin, WANG Yaoting, WANG Hongyu, YAN Xingzhou. Effect of hyperbaric oxygen therapy combined with repetitive peripheral magnetic stimulation on ankle motor function and balance of stroke patients [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2023, 29(8): 875-881.
[13]	WANG Ya'nan, LIU Xihua. Correlation and predictive effect of subjective and objective balance function measurements in stroke patients with hemiplegia [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2023, 29(8): 890-895.
[14]	JIANG Changhao, HUANG Chen, GAO Xiaoyan, DAI Yuanfu, ZHAO Guoming. Effect of neurofeedback training on cognitive function in the elderly: a systematic review [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2023, 29(8): 903-909.
[15]	WEI Xiaowei, YANG Jian, WEI Chunyan, HE Qiling. Adapted physical education programs for psychomotor development in school settings for children with intellectual and developmental disabilities: a systematic review [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2023, 29(8): 910-918.

Advance in Clinial and Mechanism Reseaches about Serotonin Selective Reuptake Inhibitors for Ischemic Stroke (review)

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Metrics

Comments

Recommended 0