蛋白酶体α6亚单位基因1233A/T位点多态性与脑梗死的关系

doi:10.3969/j.issn.1006-9771.2019.08.014

Abstract

Abstract: Objective To evaluate the relationship between 1233A/T polymorphism of proteasome subunit α type 6 (PSMA6) gene and cerebral infarction in Chinese Han population. Methods From January, 2012 to April, 2015, 211 cerebral infarction patients (case group) and 201 healthy controls (control group) were selected in the study. The single nucleotide polymorphism of 1233A/T of PSMA6 gene was identified by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP), and genotypes and allele frequency distributions in two groups were analyzed. Results The frequencies of CC, CT+TT genetype and the C allele all revealed no significant difference between two groups (χ² < 0.053, P > 0.05). After stratified by gender, the difference among all genetypes and C allele were still not significant between two groups in either male or female (χ² < 2.735, P > 0.05). Conclusion The 1233A/T of PSMA6 gene might not be associated with cerebral infarction.

Key words: proteasome subunit α type 6, single nucleotide polymorphism, cerebral infarction

CLC Number:

R743.32

HE Fang-mei, REN Chun-xiao, SONG Chun-xia, GAO Hui-xia, WANG Jing-jing. Relationship of 1233A/T Polymorphism of Proteasome Subunit α Type 6 Gene with Cerebral Infarction[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2019, 25(8): 966-970.

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Relationship of 1233A/T Polymorphism of Proteasome Subunit α Type 6 Gene with Cerebral Infarction

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