急性创伤性完全性脊髓损伤患者肠道菌群多样性研究

doi:10.3969/j.issn.1006-9771.2019.12.014

Abstract

Abstract: Objective To Compare and analyze the gut microbiota and biochemical indexes between patients with acute traumatic complete spinal cord injury and healthy subjects. Methods From May, 2017 to May, 2018, a total of 44 patients with acute traumatic complete spinal cord injury (patient group) and 33 healthy controls (control group) were included. The clinical data and fresh blood, urine and fecal samples of the two groups were collected. The V3-V4 region of 16S rRNA gene was sequenced and analyzed. Results The abundance of gut microbiota was higher in the patient group than in the control group, and the structural composition was different. Compared with the control group, the expression of Bacteroidetes decreased (P < 0.05), and the expression of Actinobacteria, Proteobacteria, Synergistetes, Saccharibacteria and Cyanobacteria increased in the patient group (P < 0.05). The serum glucose, low density lipoprotein, triglyceride and total cholesterol were significantly higher in the patient group than in the control group (P < 0 05). There was a significant correlation between these elevated markers and intestinal microbial community structure (P < 0.05). Conclusion There is gut microbiota dysbiosis in patients with acute traumatic complete spinal cord injury, and the changes of the microbiota are related to the elevation of some serum biomarkers.

Key words: spinal cord injury, gut microbiota, microbial diversity, serum biomarker

CLC Number:

R651.2

ZHANG Jie, LI Jian-jun, ZHANG Chao, YANG De-gang, YANG Ming-liang, DU Liang-jie, GAO Feng, SHEN Min-xin. Diversity of Gut Microbiota in Patients with Acute Traumatic Complete Spinal Cord Injury[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2019, 25(12): 1450-1457.

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Diversity of Gut Microbiota in Patients with Acute Traumatic Complete Spinal Cord Injury

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