Abstract: Objective To observe the clinical effect of low and medium intensity aerobic exercise combined with resistance exercise on patients with chronic kidney disease (CKD) complicated with sarcopenia. Methods From 2018 to 2019, 11 elderly patients with CKD complicated with sarcopenia were enrolled in this study. All the patients received low and medium intensity aerobic exercise combined with resistance exercise intervention on the basis of regular internal medical treatment. Each exercise section included 30 to 50 minutes of aerobic exercise and 20 to 30 minutes of resistance exercise, and was conducted three times a week for twelve weeks. Before exercise, and 24 hours, six weeks and twelve weeks after exercise, the related indicators were measured. Results No statistical difference in serum lipids and renal function indicators was found 24 hours after exercise, and six and twelve weeks post exercise (P > 0.05). Compared with pre-exercise condition, the reach in seat increased six weeks after exercise (P < 0.05); the appendicular skeletal muscle mass index, the grip strength index, the 6-meter walking speed, the peak oxygen uptake (VO_2peak), the one-leg standing time and the reach in seat improved twelve weeks after exercise (P < 0.05). Compared with the results six weeks after exercise, the grip strength index, the 6-meter walking speed, VO_2peak and the one-leg standing time improved twelve weeks after exercise (P < 0.05). Conclusion Structured exercise training of low and medium intensity aerobic exercise combined with resistance exercise training would not worsen the renal function of patients with CKD complicated with sarcopenia; however, it could improve the muscle mass, strength and motor function of them.

Key words: chronic kidney disease, sarcopenia, elderly, aerobic training, resistance training