Notch和Wnt通路对脑缺血后神经干细胞作用的研究进展

doi:10.3969/j.issn.1006-9771.2020.01.009

Abstract

Abstract:

Neural stem cells (NSCs) play a key role in repair of neurological dysfunction after cerebral ischemia. Notch pathway widely exists in animal cells and is a classical signaling pathway regulating the proliferation and differentiation of NSCs. Wnt pathway is involved in cell proliferation, differentiation and apoptosis, and plays an important role in proliferation of NSCs in brain tissue after injury. The recent studies found that the two pathways form a signaling network to regulate proliferation and differentiation of NSCs.

Key words: cerebral ischemia, neural stem cells, Notch, Wnt, pathway, review

CLC Number:

R743.3

SU Ming-zhu,MA Yue-wen. Advance in Roles of Notch and Wnt Pathways for Neural Stem Cells after Cerebral Ischemia (review)[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2020, 26(1): 55-58.

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Advance in Roles of Notch and Wnt Pathways for Neural Stem Cells after Cerebral Ischemia (review)

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