Abstract:

Objective To investigate the correlation between the change of color vision and anxiety or depression in patients with Parkinson's disease (PD). Methods From November, 2018 to November, 2019, 63 PD patients from the PD database of Department of Neurology, Dalian Friendship Hospital were selected, and they were tested with Farnsworth-Munsell 100 Hue Test (FMT), Hamilton Anxiety Scale (HAMA), Hamilton Depression Scale (HAMD), Self-rating Anxiety Scale (SAS), Self-rating Depression Scale (SDS) and Hospital Anxiety and Depression Scale (HADS). Their age, gender, course of disease, education level, Hoehn-Yahr (H-Y) stage, Unified Parkinson's Disease Rating Scale part III (UPDRSIII), levodopa dose, and scores of Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) were collected as related factors, and anlyzed with correlation analysis and multivariate regression. Results The score of FMT was correlated with the scores of HAMA, SAS, HAMD, SDS, and both HADS anxiety and depression (r > 0.561, P < 0.001). Age, H-Y stage, course of disease, score of UPDRSIII, levodopa dose and scores of MMSE and MoCA were related with the score of FMT independently. Conclusion Color vision dysfunction in PD patients is correlated to the severity of anxiety and depression, and it is affected with age, severity of PD and cognitive impairment.

Key words: Parkinson's disease, color vision, anxiety, depression