脊髓损伤患者大脑中央前回的代谢改变

doi:10.3969/j.issn.1006-9771.2020.04.003

Abstract

Abstract:

Objective To investigate the changes of metabolite concentration in the precentral gyrus (primary motor cortex, M1) in spinal cord injury (SCI) patients.Methods From December, 2018 to October, 2019, 20 SCI patients and 15 healthy controls were scaned with magnetic resonance spectroscopy to measure the concentrations of N-acetylaspartate (NAA), choline (Cho), creatine (Cr) and myo-inositol (MI) in region of interest (ROI) of left M1. Results Concentration of MI was more in the patients than in the controls (t = 3.745, P < 0.01). There was no significant difference in the concentrations of NAA, Cho and Cr, as well as the ratios of NAA/Cr, Cho/Cr, Cho/NAA between the patients and the controls ( t < 1.431, P > 0.05). Conclusion There may be hyperplasia of glial cells in M1 of SCI patients, indicating compensatory repair in cerebral motor cortex.

Key words: spinal cord injury, magnetic resonance spectroscopy, precentral gyrus, primary motor cortex, gial cells, hyperplasia, repair

CLC Number:

R651.2

LI Ya-jing,LI Jian-jun,GAO Feng,GUO Yun,LIU Jun,XU Pei-pei. Metabolism Levels in Precentral Gyrus of Patients after Spinal Cord Injury[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2020, 26(4): 382-387.

Figures/Tables 2

References 57

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代谢物	对照组 (n = 15)	患者组 (n = 20)	t值	P值
NAA(mmol/kg)	0.10±0.01	0.09±0.03	-0.645	0.524
Cho(mmol/kg)	0.04±0.01	0.04±0.01	0.776	0.443
MI(mmol/kg)	0.01±0.01	0.02±0.01	3.745	0.001
Cr(mmol/kg)	0.05±0.01	0.05±0.02	1.267	0.214
NAA/Cr	2.04±0.55	2.03±0.68	-0.033	0.974
CHO/Cr	0.66±0.24	0.92±0.83	1.140	0.262
CHO/NAA	0.34±0.14	0.42±0.16	1.431	0.162

Metabolism Levels in Precentral Gyrus of Patients after Spinal Cord Injury

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