《Chinese Journal of Rehabilitation Theory and Practice》 ›› 2020, Vol. 26 ›› Issue (5): 559-562.doi: 10.3969/j.issn.1006-9771.2020.05.013

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Advances in Drugs for Microglia Polarization after Ischemic Stroke (review)

DENG Du-ping1,FAN Jin1,XIE Xiao-long1,LI Ling-xin2()   

  1. 1. College of Health Care and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610075, China
    2. Department of Rehabilitation, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China
  • Received:2019-08-13 Revised:2019-10-14 Published:2020-05-25 Online:2020-05-29
  • Contact: LI Ling-xin E-mail:lilingxin111@163.com
  • Supported by:
    Sichuan Science and Technology Department Support Plan(2016SZ0039);Sichuan Science and Technology Department Research and Development Key Project(18ZDYF2033)

Abstract:

Microglia cells are activated after ischemic stroke, and polarized phenotypes of M1 and M2. Some drugs, such as fingolimod, 3-N-butylphthalide, curcumin, sildenafil, exendin-4, celastrol, omega-3 fatty acids, malibatol A, salidroside, etc., can transfer the polarization from M1 to M2, and may benefit the outcome of ischemic stroke.

Key words: ischemic stroke, microglia, phenotype, drugs, review

CLC Number: