《Chinese Journal of Rehabilitation Theory and Practice》 ›› 2020, Vol. 26 ›› Issue (5): 559-562.doi: 10.3969/j.issn.1006-9771.2020.05.013
Previous Articles Next Articles
DENG Du-ping1,FAN Jin1,XIE Xiao-long1,LI Ling-xin2()
Received:
2019-08-13
Revised:
2019-10-14
Published:
2020-05-25
Online:
2020-05-29
Contact:
LI Ling-xin
E-mail:lilingxin111@163.com
Supported by:
CLC Number:
DENG Du-ping,FAN Jin,XIE Xiao-long,LI Ling-xin. Advances in Drugs for Microglia Polarization after Ischemic Stroke (review)[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2020, 26(5): 559-562.
[1] |
Simone V, Arturo C, Marco A, et al. Postischemic inflammation in acute stroke[J]. J Clin Neurol, 2017, 13(1):1-9.
doi: 10.3988/jcn.2017.13.1.1 pmid: 28079313 |
[2] |
Umekawa T, Osman A M, Han W, et al. Resident microglia, rather than blood-derived macrophages, contribute to the earlier and more pronounced inflammatory reaction in the immature compared with the adult hippocampus after hypoxia-ischemia[J]. Glia, 2015, 63(12):2220-2230.
doi: 10.1002/glia.v63.12 |
[3] |
Kierdorf K, Erny D, Goldmann T, et al. Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways[J]. Nat Neurosci, 2013, 16(3):273-280.
doi: 10.1038/nn.3318 pmid: 23334579 |
[4] |
Hu X, Leak R K, Shi Y, et al. Microglial and macrophage polarization—new prospects for brain repair[J]. Nat Rev Neurol, 2014, 11(1):56-64.
doi: 10.1038/nrneurol.2014.207 |
[5] |
Hu X, Li P, Guo Y, et al. Microglia/macrophage polarization dynamics reveal novel mechanism of injury expansion after focal cerebral ischemia[J]. Stroke, 2012, 43(11):3063-3070.
doi: 10.1161/STROKEAHA.112.659656 |
[6] |
Xiong X Y, Liu L, Yang Q W. Functions and mechanisms of microglia/macrophages in neuroinflammation and neurogenesis during stroke[J]. Prog Neurobiol, 2016, 142:23-44.
doi: 10.1016/j.pneurobio.2016.05.001 |
[7] | Benakis C, Garcia-Bonilla L, Iadecola C, et al. The role of microglia and myeloid immune cells in acute cerebral ischemia[J]. Front Cell Neurosci, 2015, 8:461. |
[8] |
Chu H X, Broughton B R S, Ah Kim H, et al. Evidence that CLy6C(hi) monocytes are protective in acute ischemic stroke by promoting M2 macrophage polarization[J]. Stroke, 2015, 46(7):1929-1937.
doi: 10.1161/STROKEAHA.115.009426 |
[9] |
Kanazawa M, Miura M, Toriyabe M, et al. Microglia preconditioned by oxygen-glucose deprivation promote functional recovery in ischemic rats[J]. Sci Rep, 2017, 7:42582.
doi: 10.1038/srep42582 pmid: 28195185 |
[10] |
Cohen J A, Chun J. Mechanisms of fingolimod’s efficacy and adverse effects in multiple sclerosis[J]. Ann Neurol, 2011, 69(5):759-777.
doi: 10.1002/ana.v69.5 |
[11] |
Gaire B P, Song M R, Choi J W. Sphingosine 1-phosphate receptor subtype 3 (S1P3) contributes to brain injury after transient focal cerebral ischemia via modulating microglial activation and their M1 polarization[J]. J Neuroinflammation, 2018, 15(1):284.
doi: 10.1186/s12974-018-1323-1 |
[12] |
Li X, Wang M H, Qin C, et al. Fingolimod suppresses neuronal autophagy through the mTOR/p70S6K pathway and alleviates ischemic brain damage in mice[J]. PLoS One, 2017, 12(11):e0188748.
doi: 10.1371/journal.pone.0188748 |
[13] |
Kraft P, Gob E, Gobel K, et al. FTY720 ameliorates acute ischemic stroke in mice by reducing thrombo-inflammation but not by direct neuroprotection[J]. Stroke, 2013, 44(11):3202-3210.
doi: 10.1161/STROKEAHA.113.002880 |
[14] |
Campos F, Qin T, Castillo J, et al. Fingolimod reduces hemorrhagic transformation associated with delayed tissue plasminogen activator treatment in a mouse thromboembolic model[J]. Stroke, 2013, 44(2):505-511.
doi: 10.1161/STROKEAHA.112.679043 |
[15] |
Qin C, Fan W H, Liu Q, et al. Fingolimod protects against ischemic white matter damage by modulating microglia toward M2 polarization via STAT3 pathway[J]. Stroke, 2017, 48(12):3336-3346.
doi: 10.1161/STROKEAHA.117.018505 |
[16] | Ali A I, Jing G Y. A review of recent advances in neuroprotective potential of 3-N-butylphthalide and its derivatives[J]. Biomed Res Int, 2016, 2016:1-9. |
[17] |
Zhao H, Yun W, Zhang Q, et al. Mobilization of circulating endothelial progenitor cells by DL-3-N-butylphthalide in acute ischemic stroke patients[J]. J Stroke Cerebrovasc Dis, 2016, 25(4):752-760.
doi: 10.1016/j.jstrokecerebrovasdis.2015.11.018 |
[18] |
Hu J, Wen Q, Wu Y, et al. The effect of butylphthalide on the brain edema, blood-brain barrier of rats after focal cerebral infarction and the expression of Rho A[J]. Cell Biochem Biophys, 2014, 69(2):363-368.
doi: 10.1007/s12013-013-9808-0 |
[19] |
Li F, Ma Q, Zhao Q, et al. L-3-N-butylphthalide reduces ischemic stroke injury and increases M2 microglial polarization[J]. Metab Brain Dis, 2018, 33(6):1995-2003.
doi: 10.1007/s11011-018-0307-2 |
[20] |
Xie C J, Gu A P, Cai J, et al. Curcumin protects neural cells against ischemic injury in N2a cells and mouse brain with ischemic stroke[J]. Brain Behav, 2018, 8(2):e00921.
doi: 10.1002/brb3.2018.8.issue-2 |
[21] |
Miao Y, Zhao S, Gao Y, et al. Curcumin pretreatment attenuates inflammation and mitochondrial dysfunction in experimental stroke: the possible role of Sirt1 signaling[J]. Brain Res Bull, 2016, 121:9-15.
doi: 10.1016/j.brainresbull.2015.11.019 |
[22] |
Wu J, Li Q, Wang X, et al. Neuroprotection by curcumin in ischemic brain injury involves the Akt/Nrf2 pathway[J]. PLoS One, 2013, 8(3):e59843.
doi: 10.1371/journal.pone.0059843 |
[23] |
Liu Z, Ran Y, Huang S, et al. Curcumin protects against ischemic stroke by titrating microglia/macrophage polarization[J]. Front Aging Neurosci, 2017, 9:233.
doi: 10.3389/fnagi.2017.00233 |
[24] |
Zhang R, Wang Y, Zhang L, et al. Sildenafil (Viagra) induces neurogenesis and promotes functional recovery after stroke in rats[J]. Stroke, 2002, 33(11):2675-2680.
doi: 10.1161/01.STR.0000034399.95249.59 |
[25] |
Ding G, Jiang Q, Li L, et al. Magnetic resonance imaging investigation of axonal remodeling and angiogenesis after embolic stroke in sildenafil-treated rats[J]. J Cereb Blood Flow Metab, 2008, 28(8):1440-1448.
doi: 10.1038/jcbfm.2008.33 |
[26] |
Barros-Minones L, Orejana L, Goni-Allo B, et al. Modulation of the ASK1-MKK3/6-p38/MAPK signalling pathway mediates sildenafil protection against chemical hypoxia caused by malonate[J]. Br J Pharmacol, 2013, 168(8):1820-1834.
doi: 10.1111/bph.12071 |
[27] |
Barros-Miñones L, Martín-de-Saavedra D, Perez-Alvarez S, et al. Inhibition of calpain-regulated p35/cdk5 plays a central role in sildenafil-induced protection against chemical hypoxia produced by malonate[J]. Biochim Biophys Acta, 2013, 1832(6):705-717.
doi: 10.1016/j.bbadis.2013.02.002 pmid: 23415811 |
[28] |
Moretti R, Leger P L, Besson Valérie C, et al. Sildenafil, a cyclic GMP phosphodiesterase inhibitor, induces microglial modulation after focal ischemia in the neonatal mouse brain[J]. J Neuroinflammation, 2016, 13(1):95.
doi: 10.1186/s12974-016-0560-4 |
[29] |
Darsalia V, Mansouri S, Ortsäter H, et al. Glucagon-like peptide-1 receptor activation reduces ischaemic brain damage following stroke in type 2 diabetic rats[J]. Clin Sci (Lond), 2011, 122(10):473-483.
doi: 10.1042/CS20110374 |
[30] |
Darsalia V, Hua S, Larsson M, et al. Exendin-4 reduces ischemic brain injury in normal and aged type 2 diabetic mice and promotes microglial M2 polarization[J]. PLoS One, 2014, 9(8):e103114.
doi: 10.1371/journal.pone.0103114 |
[31] |
Kim S, Jeong J, Jung H S, et al. Anti-inflammatory effect of glucagon like peptide-1 receptor agonist, exendin-4, through modulation of IB1/JIP1 expression and JNK signaling in stroke[J]. Exp Neurobiol, 2017, 26(4):227-239.
doi: 10.5607/en.2017.26.4.227 |
[32] |
Teramoto S, Miyamoto N, Yatomi K, et al. Exendin-4, a glucagon-like peptide-1 receptor agonist, provides neuroprotection in mice transient focal cerebral ischemia[J]. J Cereb Blood Flow Metab, 2011, 31(8):1696-1705.
doi: 10.1038/jcbfm.2011.51 |
[33] |
Chen F, Wang W, Ding H, et al. The glucagon-like peptide-1 receptor agonist exendin-4 ameliorates warfarin-associated hemorrhagic transformation after cerebral ischemia[J]. J Neuroinflammation, 2016, 13(1):204.
doi: 10.1186/s12974-016-0661-0 |
[34] |
Lee C H, Yan B C, Choi J H, et al. Ischemia-induced changes in glucagon-like peptide-1 receptor and neuroprotective effect of its agonist, exendin-4, in experimental transient cerebral ischemia[J]. J Neurosci Res, 2011, 89(7):1103-1113.
doi: 10.1002/jnr.22596 |
[35] |
Barker E C, Kim B G, Yoon J H, et al. Potent suppression of both spontaneous and carcinogen-induced colitis-associated colorectal cancer in mice by dietary celastrol supplementation[J]. Carcinogenesis, 2018, 39(1):36-46.
doi: 10.1093/carcin/bgx115 pmid: 29069290 |
[36] |
Ren B, Liu H, Gao H, et al. Celastrol induces apoptosis in hepatocellular carcinoma cells via targeting ER-stress/UPR[J]. Oncotarget, 2017, 8(54):93039-93050.
doi: 10.18632/oncotarget.21750 pmid: 29190976 |
[37] |
Astry B, Venkatesha S H, Laurence A, et al. Celastrol, a Chinese herbal compound, controls autoimmune inflammation by altering the balance of pathogenic and regulatory T cells in the target organ[J]. Clin Immunol, 2015, 157(2):228-238.
doi: 10.1016/j.clim.2015.01.011 |
[38] |
Luo D, Guo Y, Cheng Y, et al. Natural product celastrol suppressed macrophage M1 polarization against inflammation in diet-induced obese mice via regulating Nrf2/HO-1, MAP kinase and NF-κB pathways[J]. Aging, 2017, 9(10):2069-2082.
doi: 10.18632/aging.v9i10 |
[39] |
Bai S, Hu Z, Yang Y, et al. Anti‐inflammatory and neuroprotective effects of Triptolide via the NF‐κB signaling pathway in a rat MCAO model[J]. Anat Rec, 2016, 299(2):256-266.
doi: 10.1002/ar.23293 |
[40] |
Jiang M, Liu X, Zhang D, et al. Celastrol treatment protects against acute ischemic stroke-induced brain injury by promoting an IL-33/ST2 axis-mediated microglia/macrophage M2 polarization[J]. J Neuroinflammation, 2018, 15(1):78.
doi: 10.1186/s12974-018-1124-6 |
[41] |
Zhang M, Wang S, Mao L, et al. Omega-3 fatty acids protect the brain against ischemic injury by activating Nrf2 and upregulating heme oxygenase 1[J]. J Neurosci, 2014, 34(5):1903-1915.
doi: 10.1523/JNEUROSCI.4043-13.2014 |
[42] |
Yang B, Ren X L, Huang H, et al. Circulating long-chain n-3 polyunsaturated fatty acid and incidence of stroke: a meta-analysis of prospective cohort studies[J]. Oncotarget, 2017, 8(48):83781-83791.
doi: 10.18632/oncotarget.19530 pmid: 29137382 |
[43] |
Mengfei C, Wenting Z, Zhongfang W, et al. Promoting neurovascular recovery in aged mice after ischemic stroke - prophylactic effect of omega: 3 polyunsaturated fatty acids[J]. Aging Dis, 2017, 8(5):531-545.
doi: 10.14336/AD.2017.0520 pmid: 28966799 |
[44] |
Dirk B, Konrad K, Nicole F, et al. Intravenous treatment with a long-chain omega-3 lipid emulsion provides neuroprotection in a murine model of ischemic stroke: a pilot study[J]. PLoS One, 2016, 11(11):e0167329.
doi: 10.1371/journal.pone.0167329 |
[45] |
Jiang X, Pu H, Hu X, et al. A post-stroke therapeutic regimen with omega-3 polyunsaturated fatty acids that promotes white matter integrity and beneficial microglial responses after cerebral ischemia[J]. Transl Stroke Res, 2016, 7(6):548-561.
doi: 10.1007/s12975-016-0502-6 |
[46] |
Yang W, Chen X, Pan J, et al. Malibatol A protects against brain injury through reversing mitochondrial dysfunction in experimental stroke[J]. Neurochem Int, 2015, 80:33-40.
doi: 10.1016/j.neuint.2014.11.003 |
[47] |
Pan J, Jin J L, Ge H M, et al. Malibatol A regulates microglia M1/M2 polarization in experimental stroke in a PPARγ-dependent manner[J]. J Neuroinflammation, 2015, 12(1):51.
doi: 10.1186/s12974-015-0270-3 |
[48] |
Weng L, Wu Z, Zheng W, et al. Malibatol A enhances alternative activation of microglia by inhibiting phosphorylation of mammalian Ste20-like kinase 1 in OGD-BV-2 cells[J]. Neurol Res, 2016, 38:342-348.
doi: 10.1080/01616412.2016.1174423 |
[49] |
Han J, Xiao Q, Lin Y H, et al. Neuroprotective effects of salidroside on focal cerebral ischemia/reperfusion injury involve the nuclear erythroid 2-related factor 2 pathway[J]. Neural Regen Res, 2015, 10(12):1989-1996.
doi: 10.4103/1673-5374.172317 |
[50] |
Liu X, Wen S, Yan F, et al. Salidroside provides neuroprotection by modulating microglial polarization after cerebral ischemia[J]. J Neuroinflammation, 2018, 15(1):39.
doi: 10.1186/s12974-018-1081-0 |
[51] |
Wei H, Sun T, Tian Y, et al. Ginkgolide B modulates BDNF expression in acute ischemic stroke[J]. J Korean Neurosurg Soc, 2017, 60(4):391-396.
doi: 10.3340/jkns.2016.1010.018 |
[52] |
He Y, Ma X, Li D, et al. Thiamet G mediates neuroprotection in experimental stroke by modulating microglia/macrophage polarization and inhibiting NF-κB p65 signaling[J]. J Cereb Blood Flow Metab, 2017, 37(8):2938-2951.
doi: 10.1177/0271678X16679671 |
[53] |
Potey C, Ouk T, Petrault O, et al. Early treatment with atorvastatin exerts parenchymal and vascular protective effects in experimental cerebral ischaemia[J]. Br J Pharmacol, 2015, 172(21):5188-5198.
doi: 10.1111/bph.2015.172.issue-21 |
[54] |
Yew W P, Djukic N D, Jayaseelan J S P, et al. Early treatment with minocycline following stroke in rats improves functional recovery and differentially modifies responses of peri-infarct microglia and astrocytes[J]. J Neuroinflammation, 2019, 16(1):6.
doi: 10.1186/s12974-018-1379-y |
[1] | SHAO Weiting, LEI Jianghua. Effect of response interruption and redirection as a behavioral intervention on vocal stereotypy in children with autism spectrum disorder: a scoping review [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2024, 30(1): 10-20. |
[2] | WANG Hangyu, GE Keke, FAN Yonghong, DU Lilu, ZOU Min, FENG Lei. Effect of active music therapy on cognitive function for older adults with cognitive impairment: a systematic review based on ICD-11 and ICF [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2024, 30(1): 36-43. |
[3] | WEN Jianing, JIN Qiuyan, ZHANG Qi, LI Jie, SI Qi. Effect of cognitively engaging physical activity on developing executive function of children and adolescents: a systematic review based on ICF [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2024, 30(1): 44-53. |
[4] | GE Keke, FAN Yonghong, WANG Hangyu, DU Lilu, LI Changjiang, ZOU Min. Health benefit of mindfulness intervention for older adults with insomnia disorders: a systematic review [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2024, 30(1): 54-60. |
[5] | ZHANG Jingya, ZOU Min, SUN Hongwei, SUN Changlong, ZHU Juntong. Effect of psychological intervention on anxiety or depression in children and adolescents with hearing impairment: a systematic review [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2023, 29(9): 1004-1011. |
[6] | WANG Junyu, YANG Yong, YUAN Xun, XIE Ting, ZHUANG Jie. Effect of high-intensity interval training on executive function for healthy children and adolescents: a systematic review [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2023, 29(9): 1012-1020. |
[7] | WEI Xiaowei, YANG Jian, WEI Chunyan. Psychological and behavioral benefits of adapted yoga exercise for children with autism spectrum disorder in special education schools: a systematic review [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2023, 29(9): 1021-1028. |
[8] | YANG Yaru, YANG Jian. School-based physical activity-related health services and their health benefits within the World Health Organization health-promoting school framework: a systematic review of systematic reviews [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2023, 29(9): 1040-1047. |
[9] | WANG He, HAN Liang, KAN Mengfan, YU Shaohong. Efficacy of electrical stimulation on shoulder-hand syndrome after stroke: a systematic review and meta-analysis [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2023, 29(9): 1048-1056. |
[10] | SHI Jiawei, LI Lingyu, YANG Haojie, WANG Qinlu, ZOU Haiou. Effect of preoperative prerehabilitation training on total knee arthroplasty: a systematic review of systematic reviews [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2023, 29(9): 1057-1064. |
[11] | JIANG Changhao, HUANG Chen, GAO Xiaoyan, DAI Yuanfu, ZHAO Guoming. Effect of neurofeedback training on cognitive function in the elderly: a systematic review [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2023, 29(8): 903-909. |
[12] | WEI Xiaowei, YANG Jian, WEI Chunyan, HE Qiling. Adapted physical education programs for psychomotor development in school settings for children with intellectual and developmental disabilities: a systematic review [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2023, 29(8): 910-918. |
[13] | ZHANG Yuan, YANG Jian. School health services and effectiveness based on World Health Organization health-promoting school framework: a scoping review [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2023, 29(7): 791-799. |
[14] | WANG Shaopu, CHEN Gang. Psychological-behavioral health services and its outcome based on World Health Organization health-promoting school framework: a systematic review of systematic reviews [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2023, 29(7): 800-807. |
[15] | JIANG Changhao, GAO Xiaoyan. Effect of acute physical activity on cognitive function in children: a systematic review [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2023, 29(6): 667-672. |
Viewed | ||||||
Full text |
|
|||||
Abstract |
|
|||||
|