Wnt信号通路在周围神经损伤后骨质疏松中的研究进展

doi:10.3969/j.issn.1006-9771.2020.08.011

Abstract

Abstract:

Wnt signaling pathway plays an important role in bone metabolism. Wnt signaling pathway inhibitors are mediated by the mechanical load, while nerve growth factors and neuropeptide (neuropeptide substance P and neuropeptide Y), which are closely related to the peripheral nervous system, affect bone metabolism through the Wnt signaling pathway. This paper reviewed the mechanism of Wnt signaling pathway in osteoporosis after peripheral nerve injury from these two aspects.

Key words: Wnt signaling pathway, peripheral nerve injury, osteoporosis, mechanical load, review

CLC Number:

R745

WANG Yan,WANG Yan. Advances of Wnt Signaling Pathway in Osteoporosis after Peripheral Nerve Injuries (review)[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2020, 26(8): 930-935.

References 70

[1]	Yao R, Nishii K, Kito T, et al. A novel device to prevent osteoporosis by promoting bone metabolism using a newly developed double-loading stimulation with vibration and shaking[J]. Okajimas Folia Anat Jpn, 2019, 96(1):13-21. doi: 10.2535/ofaj.96.13
[2]	Ehrlich P J, Lanyon L E. Mechanical strain and bone cell function: a review[J]. Osteoporos Int, 2002, 13(9):688-700. pmid: 12195532
[3]	Elefteriou F, Campbell P, Ma Y. Control of bone remodeling by the peripheral sympathetic nervous system[J]. Calcif Tissue Int, 2014, 94(1):140-151. doi: 10.1007/s00223-013-9752-4
[4]	Marrella A, Lee T Y, Lee D H, et al. Engineering vascularized and innervated bone biomaterials for improved skeletal tissue regeneration[J]. Mater Today (Kidlington), 2018, 21(4):362-376.
[5]	Hofman M, Rabenschlag F, Andruszkow H, et al. Effect of neurokinin-1-receptor blockage on fracture healing in rats[J]. Sci Rep, 2019, 9(1):9744-9754. doi: 10.1038/s41598-019-46278-6
[6]	Horsnell H, Baldock P A. Osteoblastic actions of the neuropeptide Y system to regulate bone and energy homeostasis[J]. Curr Osteoporos Rep, 2016, 14(1):26-31. doi: 10.1007/s11914-016-0300-9 pmid: 26872458
[7]	Lee N J, Clarke I M, Zengin A, et al. RANK deletion in neuropeptide Y neurones attenuates oestrogen deficiency-related bone loss[J]. J Neuroendocrinol, 2019, 31(2):e12687. doi: 10.1111/jne.2019.31.issue-2
[8]	Kodama D, Hirai T, Kondo H, et al. Bidirectional communication between sensory neurons and osteoblasts in an in vitro coculture system[J]. FEBS Lett, 2017, 591(3):527-539. doi: 10.1002/feb2.2017.591.issue-3
[9]	Houschyar K S, Tapking C, Borrelli M R, et al. Wnt pathway in bone repair and regeneration: what do we know so far[J]. Front Cell Dev Biol, 2018, 6:170-183. doi: 10.3389/fcell.2018.00170 pmid: 30666305
[10]	Nusse R, Varmus H. Three decades of Wnts: a personal perspective on how a scientific field developed[J]. EMBO J, 2012, 31(12):2670-2684. doi: 10.1038/emboj.2012.146
[11]	Nusse R, Varmus H E. Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome[J]. Cell, 1982, 31(1):99-109. pmid: 6297757
[12]	Rijsewijk F, Schuermann M, Wagenaar E, et al. The Drosophila homolog of the mouse mammary oncogene int-1 is identical to the segment polarity gene wingless[J]. Cell, 1987, 50(4):649-657. pmid: 3111720
[13]	Dickson C, Smith R, Brookes S, et al. Tumorigenesis by mouse mammary tumor virus: proviral activation of a cellular gene in the common integration region int-2[J]. Cell, 1984, 37(2):529-536. pmid: 6327073
[14]	Gallahan D, Callahan R. Mammary tumorigenesis in feral mice: identification of a new int locus in mouse mammary tumor virus (Czech II)-induced mammary tumors[J]. J Virol, 1987, 61(1):66-74. pmid: 3023708
[15]	Roelink H, Wagenaar E, Lopes Da Silva S, et al. Wnt-3, a gene activated by proviral insertion in mouse mammary tumors, is homologous to int-1/Wnt-1 and is normally expressed in mouse embryos and adult brain[J]. Proc Natl Acad Sci U S A, 1990, 87(12):4519-4523. pmid: 2162045
[16]	Nusse R, Brown A, Papkoff J, et al. A new nomenclature for int-1 and related genes: the Wnt gene family[J]. Cell, 1991, 64(2):231. pmid: 1846319
[17]	Clevers H, Nusse R. Wnt/beta-catenin signaling and disease[J]. Cell, 2012, 149(6):1192-1205. doi: 10.1016/j.cell.2012.05.012 pmid: 22682243
[18]	Nusse R, Clevers H. Wnt/beta-catenin signaling, disease, and emerging therapeutic modalities[J]. Cell, 2017, 169(6):985-999. doi: S0092-8674(17)30547-0 pmid: 28575679
[19]	Komiya Y, Habas R. Wnt signal transduction pathways[J]. Organogenesis, 2008, 4(2):68-75. pmid: 19279717
[20]	Ng L F, Kaur P, Bunnag N, et al. WNT signaling in disease[J]. Cells, 2019, 8(8):826-857. doi: 10.3390/cells8080826
[21]	Silva-Garcia O, Valdez-Alarcon J J, Baizabal-Aguirre V M. Wnt/beta-catenin signaling as a molecular target by pathogenic bacteria[J]. Front Immunol, 2019, 10:2135-2149. doi: 10.3389/fimmu.2019.02135 pmid: 31611869
[22]	Sebastian A, Loots G G. Genetics of Sost/SOST in sclerosteosis and van Buchem disease animal models[J]. Metabolism, 2018, 80:38-47. doi: S0026-0495(17)30279-2 pmid: 29080811
[23]	Whyte M P, Mcalister W H, Zhang F, et al. New explanation for autosomal dominant high bone mass: mutation of low-density lipoprotein receptor-related protein 6[J]. Bone, 2019, 127:228-243. doi: 10.1016/j.bone.2019.05.003
[24]	Gong Y, Slee R B, Fukai N, et al. LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development[J]. Cell, 2001, 107(4):513-523. pmid: 11719191
[25]	Galea G L, Lanyon L E, Price J S. Sclerostin's role in bone's adaptive response to mechanical loading[J]. Bone, 2017, 96:38-44. doi: 10.1016/j.bone.2016.10.008
[26]	Boyle W J, Simonet W S, Lacey D L. Osteoclast differentiation and activation[J]. Nature, 2003, 423(6937):337-342. doi: 10.1038/nature01658
[27]	Harada S, Rodan G A. Control of osteoblast function and regulation of bone mass[J]. Nature, 2003, 423(6937):349-355. doi: 10.1038/nature01660
[28]	Aslani S, Abhari A, Sakhinia E, et al. Interplay between microRNAs and Wnt, transforming growth factor-beta, and bone morphogenic protein signaling pathways promote osteoblastic differentiation of mesenchymal stem cells[J]. J Cell Physiol, 2019, 234(6):8082-8093. doi: 10.1002/jcp.v234.6
[29]	Jacome-Galarza C E, Percin G I, Muller J T, et al. Developmental origin, functional maintenance and genetic rescue of osteoclasts[J]. Nature, 2019, 568(7753):541-545. doi: 10.1038/s41586-019-1105-7 pmid: 30971820
[30]	Glass D A, 2nd, Bialek P, Ahn J D, et al. Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation[J]. Dev Cell, 2005, 8(5):751-764. doi: 10.1016/j.devcel.2005.02.017
[31]	Long H, Zhu Y, Lin Z, et al. miR-381 modulates human bone mesenchymal stromal cells (BMSCs) osteogenesis via suppressing Wnt signaling pathway during atrophic nonunion development[J]. Cell Death Dis, 2019, 10(7):470-485. doi: 10.1038/s41419-019-1693-z
[32]	Yuan Z, Li Q, Luo S, et al. PPARgamma and Wnt signaling in adipogenic and osteogenic differentiation of mesenchymal stem cells[J]. Curr Stem Cell Res Ther, 2016, 11(3):216-225. doi: 10.2174/1574888X10666150519093429
[33]	Han Y, You X, Xing W, et al. Paracrine and endocrine actions of bone-the functions of secretory proteins from osteoblasts, osteocytes, and osteoclasts[J]. Bone Res, 2018, 6:16-27. doi: 10.1038/s41413-018-0019-6
[34]	Alzahrani M M, Anam E A, Makhdom A M, et al. The effect of altering the mechanical loading environment on the expression of bone regenerating molecules in cases of distraction osteogenesis[J]. Front Endocrinol (Lausanne), 2014, 5:214-225.
[35]	Shirazi-Fard Y, Alwood J S, Schreurs A S, et al. Mechanical loading causes site-specific anabolic effects on bone following exposure to ionizing radiation[J]. Bone, 2015, 81:260-269. doi: S8756-3282(15)00293-8 pmid: 26191778
[36]	Zhou Y, Guan X, Liu T, et al. Whole body vibration improves osseointegration by up-regulating osteoblastic activity but down-regulating osteoblast-mediated osteoclastogenesis via ERK1/2 pathway[J]. Bone, 2015, 71:17-24. doi: 10.1016/j.bone.2014.09.026 pmid: 25304090
[37]	Martin M, Sansalone V, Cooper D M L, et al. Mechanobiological osteocyte feedback drives mechanostat regulation of bone in a multiscale computational model[J]. Biomech Model Mechanobiol, 2019, 18(5):1475-1496. doi: 10.1007/s10237-019-01158-w
[38]	Bellido T. Osteocyte-driven bone remodeling[J]. Calcif Tissue Int, 2014, 94(1):25-34. doi: 10.1007/s00223-013-9774-y
[39]	Koide M, Kobayashi Y. Regulatory mechanisms of sclerostin expression during bone remodeling[J]. J Bone Miner Metab, 2019, 37(1):9-17. doi: 10.1007/s00774-018-0971-7
[40]	Zhang D, Miranda M, Li X, et al. Retention of osteocytic micromorphology by sclerostin antibody in a concurrent ovariectomy and functional disuse model[J]. Ann N Y Acad Sci, 2019, 1442(1):91-103. doi: 10.1111/nyas.2019.1442.issue-1
[41]	Sawakami K, Robling A G, Ai M, et al. The Wnt co-receptor LRP5 is essential for skeletal mechanotransduction but not for the anabolic bone response to parathyroid hormone treatment[J]. J Biol Chem, 2006, 281(33):23698-23711. doi: 10.1074/jbc.M601000200
[42]	Chang M K, Kramer I, Keller H, et al. Reversing LRP5-dependent osteoporosis and SOST deficiency-induced sclerosing bone disorders by altering WNT signaling activity[J]. J Bone Miner Res, 2014, 29(1):29-42. doi: 10.1002/jbmr.2059
[43]	Liao C, Ou Y, Wu Y, et al. Sclerostin inhibits odontogenic differentiation of human pulp-derived odontoblast-like cells under mechanical stress[J]. J Cell Physiol, 2019, 234(11):20779-20789. doi: 10.1002/jcp.v234.11
[44]	Robling A G, Niziolek P J, Baldridge L A, et al. Mechanical stimulation of bone in vivo reduces osteocyte expression of Sost/sclerostin[J]. J Biol Chem, 2008, 283(9):5866-5875. doi: 10.1074/jbc.M705092200
[45]	Morse A, Mcdonald M M, Kelly N H, et al. Mechanical load increases in bone formation via a sclerostin-independent pathway[J]. J Bone Miner Res, 2014, 29(11):2456-2467. doi: 10.1002/jbmr.2278 pmid: 24821585
[46]	Mao B, Wu W, Davidson G, et al. Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling[J]. Nature, 2002, 417(6889):664-667. doi: 10.1038/nature756
[47]	Tai N, Inoue D. [Anti-Dickkopf1 (Dkk1) antibody as a bone anabolic agent for the treatment of osteoporosis][J]. [in Japanese]. Clin Calcium, 2014, 24(1):75-83.
[48]	Mcdonald M M, Morse A, Schindeler A, et al. Homozygous Dkk1 knockout mice exhibit high bone mass phenotype due to increased bone formation[J]. Calcif Tissue Int, 2018, 102(1):105-116. doi: 10.1007/s00223-017-0338-4
[49]	Morvan F, Boulukos K, Clement-Lacroix P, et al. Deletion of a single allele of the Dkk1 gene leads to an increase in bone formation and bone mass[J]. J Bone Miner Res, 2006, 21(6):934-945. doi: 10.1359/jbmr.060311
[50]	Holguin N, Brodt M D, Silva M J. Activation of Wnt signaling by mechanical loading is impaired in the bone of old mice[J]. J Bone Miner Res, 2016, 31(12):2215-2226. doi: 10.1002/jbmr.2900
[51]	Ueland T, Stilgren L, Bollerslev J. Bone matrix levels of dickkopf and sclerostin are positively correlated with bone mass and strength in postmenopausal osteoporosis[J]. Int J Mol Sci, 2019, 20(12):2896-2907. doi: 10.3390/ijms20122896
[52]	Morse A, Ko F, Mcdonald M M, et al. Increased anabolic bone response in Dkk1 KO mice following tibial compressive loading[J]. Bone, 2020, 131:115054. doi: 10.1016/j.bone.2019.115054
[53]	Van Lierop A H, Moester M J, Hamdy N A, et al. Serum Dickkopf 1 levels in sclerostin deficiency[J]. J Clin Endocrinol Metab, 2014, 99(2):E252-E256. doi: 10.1210/jc.2013-3278
[54]	Han H M, Kim T H, Bae J Y, et al. Primary sensory neurons expressing tropomyosin receptor kinase A in the rat trigeminal ganglion[J]. Neurosci Lett, 2019, 690:56-60. doi: 10.1016/j.neulet.2018.10.009
[55]	Jimenez-Andrade J M, Mantyh W G, Bloom A P, et al. A phenotypically restricted set of primary afferent nerve fibers innervate the bone versus skin: therapeutic opportunity for treating skeletal pain[J]. Bone, 2010, 46(2):306-313. doi: 10.1016/j.bone.2009.09.013 pmid: 19766746
[56]	Tomlinson R E, Li Z, Zhang Q, et al. NGF-TrkA signaling by sensory nerves coordinates the vascularization and ossification of developing endochondral bone[J]. Cell Rep, 2016, 16(10):2723-2735. doi: S2211-1247(16)31034-8 pmid: 27568565
[57]	Zhou F Q, Zhou J, Dedhar S, et al. NGF-induced axon growth is mediated by localized inactivation of GSK-3beta and functions of the microtubule plus end binding protein APC[J]. Neuron, 2004, 42(6):897-912. doi: 10.1016/j.neuron.2004.05.011
[58]	Riccio A, Pierchala B A, Ciarallo C L, et al. An NGF-TrkA-mediated retrograde signal to transcription factor CREB in sympathetic neurons[J]. Science, 1997, 277(5329):1097-1100. doi: 10.1126/science.277.5329.1097
[59]	Da Silva J T, Evangelista B G, Venega R A G, et al. Early and late behavioral changes in sciatic nerve injury may be modulated by nerve growth factor and substance P in rats: a chronic constriction injury long-term evaluation[J]. J Biol Regul Homeost Agents, 2017, 31(2):309-319.
[60]	Mach D B, Rogers S D, Sabino M C, et al. Origins of skeletal pain: sensory and sympathetic innervation of the mouse femur[J]. Neuroscience, 2002, 113(1):155-166. pmid: 12123694
[61]	Wang L, Zhao R, Shi X, et al. Substance P stimulates bone marrow stromal cell osteogenic activity, osteoclast differentiation, and resorption activity in vitro[J]. Bone, 2009, 45(2):309-320. doi: 10.1016/j.bone.2009.04.203
[62]	Wang Y, Tang Q, Zhu L, et al. Effects of treatment of treadmill combined with electro-acupuncture on tibia bone mass and substance pexpression of rabbits with sciatic nerve injury[J]. PLoS One, 2016, 11(11):e0164652. doi: 10.1371/journal.pone.0164652
[63]	Fu S, Jin D, Liu S, et al. Protective effect of neuropeptide substance P on bone marrow mesenchymal stem cells against apoptosis induced by serum deprivation[J]. Stem Cells Int, 2015, 2015:270328.
[64]	Fu S, Mei G, Wang Z, et al. Neuropeptide substance P improves osteoblastic and angiogenic differentiation capacity of bone marrow stem cells in vitro[J]. Biomed Res Int, 2014, 2014:596023.
[65]	Allen J M, Adrian T E, Polak J M, et al. Neuropeptide Y (NPY) in the adrenal gland[J]. J Auton Nerv Syst, 1983, 9(2-3):559-563. pmid: 6689331
[66]	Tatemoto K, Carlquist M, Mutt V. Neuropeptide Y: a novel brain peptide with structural similarities to peptide YY and pancreatic polypeptide[J]. Nature, 1982, 296(5858):659-660. pmid: 6896083
[67]	Liu S, Jin D, Wu J Q, et al. Neuropeptide Y stimulates osteoblastic differentiation and VEGF expression of bone marrow mesenchymal stem cells related to canonical Wnt signaling activating in vitro[J]. Neuropeptides, 2016, 56:105-113. doi: 10.1016/j.npep.2015.12.008
[68]	Wu J, Liu S, Meng H, et al. Neuropeptide Y enhances proliferation and prevents apoptosis in rat bone marrow stromal cells in association with activation of the Wnt/beta-catenin pathway in vitro[J]. Stem Cell Res, 2017, 21:74-84. doi: 10.1016/j.scr.2017.04.001
[69]	Dong P, Gu X, Zhu G, et al. Melatonin induces osteoblastic differentiation of mesenchymal stem cells and promotes fracture healing in a rat model of femoral fracture via neuropeptide Y/neuropeptide Y receptor Y1 signaling[J]. Pharmacology, 2018, 102(5-6):272-280. doi: 10.1159/000492576
[70]	Lee N J, Doyle K L, Sainsbury A, et al. Critical role for Y1 receptors in mesenchymal progenitor cell differentiation and osteoblast activity[J]. J Bone Miner Res, 2010, 25(8):1736-1747. doi: 10.1002/jbmr.61

Advances of Wnt Signaling Pathway in Osteoporosis after Peripheral Nerve Injuries (review)

RichHTML

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References 70

Related Articles 15

Metrics

Comments

Recommended 0

[1]	SHAO Weiting, LEI Jianghua. Effect of response interruption and redirection as a behavioral intervention on vocal stereotypy in children with autism spectrum disorder: a scoping review [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2024, 30(1): 10-20.
[2]	WANG Hangyu, GE Keke, FAN Yonghong, DU Lilu, ZOU Min, FENG Lei. Effect of active music therapy on cognitive function for older adults with cognitive impairment: a systematic review based on ICD-11 and ICF [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2024, 30(1): 36-43.
[3]	WEN Jianing, JIN Qiuyan, ZHANG Qi, LI Jie, SI Qi. Effect of cognitively engaging physical activity on developing executive function of children and adolescents: a systematic review based on ICF [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2024, 30(1): 44-53.
[4]	GE Keke, FAN Yonghong, WANG Hangyu, DU Lilu, LI Changjiang, ZOU Min. Health benefit of mindfulness intervention for older adults with insomnia disorders: a systematic review [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2024, 30(1): 54-60.
[5]	ZHANG Jingya, ZOU Min, SUN Hongwei, SUN Changlong, ZHU Juntong. Effect of psychological intervention on anxiety or depression in children and adolescents with hearing impairment: a systematic review [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2023, 29(9): 1004-1011.
[6]	WANG Junyu, YANG Yong, YUAN Xun, XIE Ting, ZHUANG Jie. Effect of high-intensity interval training on executive function for healthy children and adolescents: a systematic review [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2023, 29(9): 1012-1020.
[7]	WEI Xiaowei, YANG Jian, WEI Chunyan. Psychological and behavioral benefits of adapted yoga exercise for children with autism spectrum disorder in special education schools: a systematic review [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2023, 29(9): 1021-1028.
[8]	YANG Yaru, YANG Jian. School-based physical activity-related health services and their health benefits within the World Health Organization health-promoting school framework: a systematic review of systematic reviews [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2023, 29(9): 1040-1047.
[9]	WANG He, HAN Liang, KAN Mengfan, YU Shaohong. Efficacy of electrical stimulation on shoulder-hand syndrome after stroke: a systematic review and meta-analysis [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2023, 29(9): 1048-1056.
[10]	SHI Jiawei, LI Lingyu, YANG Haojie, WANG Qinlu, ZOU Haiou. Effect of preoperative prerehabilitation training on total knee arthroplasty: a systematic review of systematic reviews [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2023, 29(9): 1057-1064.
[11]	JIANG Changhao, HUANG Chen, GAO Xiaoyan, DAI Yuanfu, ZHAO Guoming. Effect of neurofeedback training on cognitive function in the elderly: a systematic review [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2023, 29(8): 903-909.
[12]	WEI Xiaowei, YANG Jian, WEI Chunyan, HE Qiling. Adapted physical education programs for psychomotor development in school settings for children with intellectual and developmental disabilities: a systematic review [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2023, 29(8): 910-918.
[13]	ZHANG Yuan, YANG Jian. School health services and effectiveness based on World Health Organization health-promoting school framework: a scoping review [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2023, 29(7): 791-799.
[14]	WANG Shaopu, CHEN Gang. Psychological-behavioral health services and its outcome based on World Health Organization health-promoting school framework: a systematic review of systematic reviews [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2023, 29(7): 800-807.
[15]	JIANG Changhao, GAO Xiaoyan. Effect of acute physical activity on cognitive function in children: a systematic review [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2023, 29(6): 667-672.