疏通矫正手法对cblC型甲基丙二酸尿症患儿功能的效果

doi:10.3969/j.issn.1006-9771.2020.08.017

Abstract

Abstract:

Objective To observe the effect of Dredging Correcting Manipulation on cblC methylmalonic aciduria (MMA).Methods From October, 2017 to October, 2018, 72 children with cblC MMA combined with growth retardation were divided into control group (n = 36) and experimental group (n = 36) according to the consent of their parents. The control group accepted routine medicine, and the experimental group received Dredging Correcting Manipulation in addition. The Griffiths Development Scale-Chinese version (GDS-C) was used to evaluate the two groups before and after treatment. At the same time, body length, body mass and head circumference were measured.Results Six cases in the control group and five cases in the experimental group were dropped out. There was no significant difference in the development quotients of GDS-C in gross movement, personal and social, hearing and speech, hand-eye coordination, operation and total quotient between two groups before treatment (P> 0.05). After treatment, all the development quotients increased in both groups (t > 6.110, P < 0.001), and the development quotients of GDS-C in gross movement, personal and social, hand-eye coordination and total quotient were higher in the experimental group than in the control group ( t > 2.154, P< 0.05), as well as the body length (t = 2.027, P < 0.05). Conclusion Dredging Correcting Manipulation can promote the neuropsychological and physical development of children with cblC MMA combined with retardation.

Key words: methylmalonic aciduria, neurodevelopmental retardation, Dredging Correcting Manipulation, Griffiths Development Scale

CLC Number:

R725.8

ZHENG Hong,LIANG Rui-xing,LU Xiang-peng,ZHANG Jian-kui,WANG Yi-zhen,XIE Ke-gong,JIN Hui,GUO Su-zhen,ZHAO Shu-ying,ZHANG Chi,LI Xiao-meng,MAO Xin,SUN Jin-long,LI Hua-wei,FENG Bin,MA Bing-xiang. Effect of Dredging Correcting Manipulation on Stunting in Children with cblC Methylmalonic Aciduria[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2020, 26(8): 964-968.

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References 21

[1]	王丽雯, 倪敏, 贾晨路, 等. 应用串联质谱技术进行河南省新生儿甲基丙二酸血症的筛查结果分析[J]. 中国优生与遗传杂志, 2019, 27(7):846-848.
	Wang L W, Ni M, Jia C L, et al. Analysis of screening results of mass spectrometry-mass spectrometry for neonatal methylmalonic academia in Henan Province[J]. Chin J Birth Health Heredity, 2019, 27(7):846-848.
[2]	韩连书. 甲基丙二酸尿症生化基因诊断及产前诊断[J]. 中国实用儿科杂志, 2018, 33(7):498-501.
	Han L S. Biochemical, genetic and prenatal diagnosis of methylmalonic aciduria[J]. Chin J Prac Pediatr, 2018, 33(7):498-501.
[3]	Manoli I, Sloan J L, Venditti C P. Isolated Methylmalonic Acidemia[M]// Adam M P, Ardinger H H, Pagon R A, et al. GeneReviews^®. Seattle, WA: University of Washington , 1993-2017.
[4]	刘怡, 刘玉鹏, 张尧, 等. 中国1003例甲基丙二酸血症的复杂临床表型、基因型及防治情况分析[J]. 中华儿科杂志, 2018, 56(6):414-420.
	Liu Y, Liu Y P, Zhang Y, et al. Heterogeneous phenotypes, genotypes, treatment and prevention of 1003 patients with methylmalonic acidemia in the mainland of China[J]. Chin J Pediatr, 2018, 56(6):414-420.
[5]	Splinter K, Niemi A K, Cox R, et al. Impaired health-related quality of life in children and families affected by methylmalonic acidemia[J]. J Genet Couns, 2016, 25(5):936-944. doi: 10.1007/s10897-015-9921-x
[6]	Han B, Cao Z, Tian L, et al. Clinical presentation, gene analysis and outcomes in young patients with early-treated combined methylmalonic acidemia and homocysteinemia (cblC type) in Shandong province, China[J]. Brain Develop, 2015, 38(5):491-497. doi: 10.1016/j.braindev.2015.10.016
[7]	Yu Y F, Li F, Ma H W. Relationship of genotypes with clinical phenotypes and outcomes in children with cobalamin C type combined methylmalonic aciduria and homocystinuria[J]. Zhongguo Dang Dai Er Ke Za Zhi, 2015, 17(8):769-774.
[8]	Splinter K, Niemi A K, Cox R, et al. Impaired health-related quality of life in children and families affected by methylmalonic acidemia[J]. J Genet Couns, 2016, 25(5):936-944. doi: 10.1007/s10897-015-9921-x
[9]	Keyfi F, Abbaszadegan M R, Sankian M, et al. Mutation analysis of genes related to methylmalonic acidemia: identification of eight novel mutations[J]. Mol Biol Rep, 2019, 46(1):271-285. doi: 10.1007/s11033-018-4469-0
[10]	陈萧群, 周熙惠, 雷玲霞. cblC型甲基丙二酸血症合并同型半胱氨酸血症临床资料分析[J]. 中国妇幼健康研究, 2017, 28(9):1133-1136.
	Chen X Q, Zhou X H, Lei L X. Clinical data analysis of cblC methylmalonic acidemia combined with homocysteinemia[J]. Chin J Woman Child Health Res, 2017, 28(9):1133-1136.
[11]	郑宏, 陆相朋. 甲基丙二酸尿症脑损伤及诊疗对策[J]. 中国实用儿科杂志, 2018, 33(7):516-520.
	Zheng H, Lu X P. Brain damage of methylmalonic aciduria and the diagnosis and treatment[J]. Chin J Prac Pediatr, 2018, 33(7):516-520.
[12]	Jimenez-Gomez A, Standridge S M. A refined approach to evaluating global developmental delay for the international medical community[J]. Pediatr Neurol, 2017, 51(2):198-206. doi: 10.1016/j.pediatrneurol.2013.12.018
[13]	Rosenblatt D S, Aspler A L, Shevell M I, et al. Clinical heterogeneity and prognosis in combined methylmalonic aciduria and homocystinuria (cblC)[J]. J Inherit Metab Dis, 1997, 20(4):528-538. pmid: 9266389
[14]	Guigonis V, Frémeaux-Bacchi V, Giraudier S, et al. Late-onset thrombocytic microangiopathy caused by cblC disease: association with a factor H mutation[J]. Am J Kidney Dis, 2005, 45(3):588-595. pmid: 15754282
[15]	Weisfeld-Adams J D, Bender H A, Miley-Åkerstedt A, et al. Neurologic and neurodevelopmental phenotypes in young children with early-treated combined methylmalonic acidemia and homocystinuria, cobalamin C type[J]. Mol Genet Metab, 2013, 110(3):241-247. doi: 10.1016/j.ymgme.2013.07.018 pmid: 23954310
[16]	陆相朋, 郑宏, 梁瑞星, 等. 甲基丙二酸血症86例患儿的神经发育特征[J]. 中华实用儿科临床杂志, 2020, 35(3):221-226.
	Lu X P, Zheng H, Liang R X, et al. Study on neurodevelopment of 86 children with methylmalonic academia[J]. Chin J Appl Clin Pediatr, 2020, 35(3):221-226.
[17]	Ktena Y P, Paul S M, Hauser N S, et al. Delineating the spectrum of impairments, disabilities, and rehabilitation needs in methylmalonic acidemia (MMA)[J]. Am J Med Genet A, 2015, 167A(9):2075-2084.
[18]	郑宏, 陆相朋, 冯斌, 等. 甲基丙二酸尿症脑损伤患儿中医证候规律研究[J]. 中医学报, 2019, 34(9):1953-1957.
	Zheng H, Lu X P, Feng B, et al. Study on TCM syndrome regularity of brain injury in children with methylmalonic aciduria[J]. Chin J Chin Med, 2019, 34(9):1953-1957.
[19]	尹翎嘉, 蔡坚雄, 路桃影, 等. 从循证视角观小儿推拿的机遇与挑战[J]. 中国循证医学杂志, 2018, 18(11):1173-1179.
	Yin L J, Cai J X, Lu T Y, et al. Opportunities and challenges of pediatric Tuina: an evidence-based perspective[J]. Chin J Evidence-Based Med, 2018, 18(11):1173-1179.
[20]	马丙祥, 冯刚, 郑宏, 等. 疏通矫正手法对痉挛型脑性瘫痪患儿GMFM、痉挛肌群表面肌电图、日常生活能力、肌张力评定的影响[J]. 中医学报, 2018, 33(5):765-769.
	Ma B X, Feng G, Zheng H, et al. Effect of Shutong Jiaozheng technique maneuver on GMFM, surface electromyogram, daily life ability and muscle tension in children with spastic cerebral palsy[J]. Chin J Chin Med, 2018, 33(5):765-769.
[21]	马丙祥, 冯刚. 疏通矫正手法治疗小儿痉挛型脑瘫的临床研究[J]. 中国康复医学杂志, 2007, 22(4):354-356.
	Ma B X, Feng G. Clinical study on treatment of infantile spastic cerebral palsy with Shutong Jiaozheng technique maneuver[J]. Chin J Rehabil Med, 2007, 22(4):354-356.

组别	n	治疗前	治疗后	t值	P值
对照组	30	49.90±16.01	56.90±16.00	7.727	< 0.001
试验组	31	52.26±18.62	69.11±19.30	21.393	< 0.001
t值		0.529	2.698
P值		0.599	0.009

组别	n	治疗前	治疗后	t值	P值
对照组	30	46.40±17.75	53.50±16.46	6.121	< 0.001
试验组	31	49.65±19.05	65.60±18.64	22.184	< 0.001
t值		0.688	2.688
P值		0.494	0.009

组别	n	治疗前	治疗后	t值	P值
对照组	30	42.70±15.40	50.05±15.99	7.191	< 0.001
试验组	31	43.35±15.66	53.74±15.56	11.361	< 0.001
t值		0.165	0.912
P值		0.870	0.365

组别	n	治疗前	治疗后	t值	P值
对照组	30	50.10±16.39	58.19±16.63	6.416	< 0.001
试验组	31	50.48±17.09	68.22±19.60	13.485	< 0.001
t值		0.089	2.157
P值		0.929	0.035

组别	n	治疗前	治疗后	t值	P值
对照组	30	49.80±17.09	58.97±17.76	6.110	< 0.001
试验组	31	50.26±17.39	65.32±18.78	11.486	< 0.001
t值		0.104	1.358
P值		0.918	0.180

Effect of Dredging Correcting Manipulation on Stunting in Children with cblC Methylmalonic Aciduria

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组别	n	治疗前	治疗后	t值	P值
对照组	30	50.10±16.39	55.51±15.38	7.930	< 0.001
试验组	31	49.20±19.21	64.41±16.86	19.183	< 0.001
t值		0.563	2.154
P值		0.576	0.036

组别	n	身长(cm)	体质量(kg)	头围(cm)
对照组	30	0.65±0.26	0.28±0.20	0.29±0.19
试验组	31	0.78±0.24	0.24±0.28	0.28±0.17
t值		2.027	-0.662	0.281
P值		0.047	0.511	0.780