线粒体介导远端缺血后处理抗脑缺血再灌注损伤的机制研究进展

doi:10.3969/j.issn.1006-9771.2020.09.011

Abstract

Abstract:

Mitochondria, as the key passway of neuronal apoptosis after ischemia, is closely related to cerebral ischemia-reperfusion injury. Remote ischemic post-conditioning can alleviate cerebral ischemia-reperfusion injury, and its mechanism is related to alleviating mitochondrial injury and improving its dysfunction. In this paper, cytochrome C/caspase, mitophagy, mitochondrial ATP-sensitive K⁺ channel and mitochondrial permeability transitionpore were reviewed.

Key words: cerebral ischemia-reperfusion injury, remote ischemic post-conditioning, mitochondria, review

TAO Miao-miao,XU Ming-shu,ZHANG Ying-jie,CHENG Ai-fang,DENG Yun-yi. Advance in Role of Mitochondria in Remote Ischemic Postconditioning for Cerebral Ischemia-reperfusion Injury (review)[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2020, 26(9): 1061-1065.

References 53

[1]	姜晋灵. 静脉溶栓治疗时间窗控制对急性缺血性脑卒中疗效的影响[J]. 中国实用神经疾病杂志, 2016, 19(19):94-95.
	Jiang J L. Effect of time window control of intravenous thrombolysis on acute ischemic stroke[J]. Chin J Pract Nerv Dis, 2016, 19(19):94-95.
[2]	Savitz S I, Baron J C, Yenari M A, et al. Reconsidering neuroprotection in the reperfusion era[J]. Stroke, 2017, 48(12):3413-3419. doi: 10.1161/STROKEAHA.117.017283 pmid: 29146878
[3]	Zhao Z Q, Corvera J S, Halkos M E, et al. Inhibition of myocardial injury by ischemic postconditioning during reperfusion: comparison with ischemic preconditioning[J]. Am J Physiol Heart Circ Physiol, 2003, 285(2):579-588.
[4]	Kerendi F, Kin H, Halkos M E, et al. Remote postconditioning. Brief renal ischemia and reperfusion applied before coronary artery reperfusion reduces myocardial infarct size via endogenous activation of adenosine receptors[J]. Basic Res Cardiol, 2005, 100(5):404-412. pmid: 15965583
[5]	Ren C, Yan Z, Wei D, et al. Limb remote ischemic postconditioning protects against focal ischemia in rats[J]. Brain Res, 2009, 1288:88-94. doi: 10.1016/j.brainres.2009.07.029
[6]	时雅辉, 赵建华, 宋金玲, 等. 短暂性肢体缺血后处理治疗急性脑梗死的疗效观察[J]. 中风与神经疾病杂志, 2017, 34(5):436-439.
	Shi Y H, Zhao J H, Song J L, et al. Observation on clinical effect of transient limb remote ischemic postconditioning in treating acute cerebral infarction[J]. J Apoplexy Nerv Dis, 2017, 34(5):436-439.
[7]	陶苗苗, 徐鸣曙, 张英杰, 等. 远端缺血后处理对缓解脑缺血再灌注损伤的研究进展[C]. 2019中国针灸学会年会暨40周年回顾论文集, 2019: 1326-1329.
	Tao M M, Xu M S, Zhang Y J, et al. Research progress of remote ischemic postconditioning in alleviating cerebral ischemia-reperfusion injury[C]. Conference 2019 and 40-years Review of Chinese Society of Acupuncture and Moxibustion, 2019: 1326-1329.
[8]	李富莹. 快速和延迟性远程缺血后处理对大鼠脑缺血保护作用研究[D]. 桂林:桂林医学院, 2014.
	Li F Y. The neuroprotection of rapid and delayed remote ischemic postconditioning on cerebral ischemia in rats and its underlying mechanisms[D]. Guilin: Guilin Medical University, 2014.
[9]	许士民. 远端肢体缺血后处理对大鼠脑缺血及再灌注损伤程度的研究[D]. 唐山:华北理工大学, 2017.
	Xu S M. Study on the degree of cerebral ischemia and reperfusion injury in rats after remote limb ischemic postconditioning[D]. Tangshan: North China University of Science and Technology, 2017.
[10]	王娇. 快速性远程缺血后处理对大鼠局部脑缺血长期保护作用的研究[C]. 中华医学会第十七次全国神经病学学术会议论文汇编(下), 2014: 308.
	Wang J. Long term protection of rapid remote ischemic postconditioning for focal cerebral ischemia in rats[C]. Proceedings of the 17th National Neurology Conference of Chinese Medical Association (2), 2014: 308.
[11]	陈历. 延迟肢体缺血后处理对大鼠急性脑梗死再灌注损伤的保护作用及其机制的探讨[D]. 唐山:华北理工大学, 2015.
	Chen L. Delayed limb ischemic postconditioning protects rats against cerebral ischemia reperfusion and its mechanism[D]. Tangshan: North China University of Science and Technology, 2015.
[12]	何洁, 吉训明. 颅内动脉狭窄患者行远隔缺血后适应治疗的单光子发射计算机断层摄影评价研究[J]. 中华老年心脑血管病杂志, 2016, 18(10):1016-1019.
	He J, Ji X M. Value of single photon emission CT in assessment of intracranial arterial stenosis patients undergoing limb ischemic postconditioning[J]. Chin J Geriatr Heart Brain Vessel Dis, 2016, 18(10):1016-1019.
[13]	于佳慧, 刘昕彦, 黄凯, 等. 芪参益气方对H₂O₂损伤的心肌细胞线粒体结构和功能的保护作用及机制探讨[J]. 中草药, 2018, 49(14):3343-3349.
	Yu J H, Liu X Y, Huang K, et al. Protective effect and mechanism of Qishen Yiqi Formula on mitochondrial structure and function of cardiomyocytes injured by H₂O₂ [J]. Chin Trad Herbal Drug, 2018, 49(14):3343-3349.
[14]	Koren E, Yosefzon Y, Ankawa R, et al. ARTS mediates apoptosis and regeneration of the intestinal stem cell niche[J]. Nat Commun, 2018, 9(1):4582. doi: 10.1038/s41467-018-06941-4 pmid: 30389919
[15]	Sanderson T H, Reynolds C A, Kumar R, et al. Molecular mechanisms of ischemia-reperfusion injury in brain: pivotal role of the mitochondrial membrane potential in reactive oxygen species generation[J]. Mol Neurobiol, 2013, 47(1):9-23. doi: 10.1007/s12035-012-8344-z pmid: 23011809
[16]	康元元, 余剑波. 线粒体融合、分裂与缺血-再灌注损伤[C]. 中国中西医结合麻醉学会年会暨第二届全国中西医结合麻醉学术研讨会、江苏省中西医结合学会麻醉专业委员会成立大会论文汇编, 2015: 303-305.
	Kang Y Y, Yu J B. Mitochondrial fusion, mitosis and ischemia-reperfusion injury[C]. Proceedings of Conference 2015 of Chinese Society of Integrated Chinese and Western Medicine Anesthesia, the 2nd National Symposium on anesthesia of Integrated Chinese and Western Medicine, and founding of Anesthesia Committee of Jiangsu Society of Integrated Traditional Chinese and Western Medicine, 2015: 303-305.
[17]	黄颖媚, 李浩. 肢体缺血后处理对脑保护作用的研究进展[J]. 华夏医学, 2018, 31(2):193-197.
	Huang Y M, Li H. Research progress on the protective effect of limb ischemic postconditioning on the brain[J]. Acta Med Sinic, 2018, 31(2):193-197.
[18]	Movassagh M, Foo R S. Simplified apoptotic cascades[J]. Heart Fail Rev, 2008, 13(2):111-119. pmid: 18080749
[19]	郝宇华. 缺血后处理对大鼠脑缺血再灌注损伤的保护作用[D]. 天津:天津医科大学, 2008.
	Hao Y H. The protective effect of postconditioning on cerebral ischemia/reperfusion injury in rats cerebrum[D]. Tianjin: Tianjin Medical University, 2008.
[20]	张慕春, 胡宪文. 七氟醚后处理的脑保护作用及其对相关凋亡信号转导通路的影响[J]. 国际麻醉学与复苏杂志, 2018, 39(6):579-584.
	Zhang M C, Hu X W. The neuroprotection of postconditioning with sevoflurane and its effect on the related apoptotic signaling transduction pathway[J]. Inter J Anesth Resuscit, 2018, 39(6):579-584.
[21]	Tajiri S, Oyadomari S, Yano S, et al. Ischemia-induced neuronal cell death is mediated by the endoplasmic reticulum stress pathway involving CHOP[J]. Cell Death Differ, 2004, 11(4):403-415. pmid: 14752508
[22]	Won S J, Minnella A M, Wu L, et al. Cofilin-actinrod formation in neuronal processes after brain ischemia[J]. PLoS One, 2018, 13(10):e0198709. doi: 10.1371/journal.pone.0198709
[23]	赵晓楠. 无创性延迟肢体缺血预适应对抗大鼠脑缺血再灌注损伤的线粒体相关机制研究[D]. 天津:天津医科大学, 2015.
	Zhao X N. Study on mitochondria-related mechanism of noninvasive delayed limb ischemic preconditioning against brain ischemic reperfusion injury[D]. Tianjin: Tianjin Medical University, 2015.
[24]	Ow Y P, Green D R, Hao Z, et al. Cytochrome C: functions beyond respiration[J]. Nat Rev Mol Cell Biol, 2008, 9(7):532-542.
[25]	van Beek-Harmsen B J, van Der Laarse W J. Immunohistochemical determination of cytosolic cytochrome C concentration in cardiomyocytes[J]. J Histochem Cytochem, 2005, 53(7):803-807. pmid: 15995138
[26]	Zhivotovsky B, Orrenius S, Brustugun O T, et al. Injected cytochrome C induces apoptosis[J]. Nature, 1998, 391(6666):449-450. pmid: 9461210
[27]	韦辰, 王士雷, 孔宪刚, 等. 补阳还五汤对脑缺血再灌注损伤大鼠线粒体分裂蛋白Drp1、Fis1及细胞色素C表达的影响[J]. 陕西中医, 2017, 38(10):1481-1483.
	Wei C, Wang S L, Kong X G, et al. Effect of Buyang Huanwu Decoction on the expression of mitochondrion Drp1, Fis1 and cytochrome C in rats with cerebral ischemia reperfusion injury[J]. Shaanxi J Trad Chin Med, 2017, 38(10):1481-1483.
[28]	邢变枝, 陈晖, 王磊, 等. 缺血后处理对脑缺血再灌注损伤后Caspase-3、Caspase-9激活和细胞色素C释放的影响[J]. 临床误诊误治, 2013, 26(8):76-79.
	Xing B Z, Chen H, Wang L, et al. Effects of ischemic postprocessing on activation of caspase-3 and caspase-9 and release of cytochrome C in reperfusion injury after cerebral ischemia[J]. Clin Misdiagn Misther, 2013, 26(8):76-79.
[29]	Wang J Y, Shen J, Gao Q, et al. Ischemic postconditioning protects against global cerebral ischemia/reperfusion-induced injury in rats[J]. Stroke, 2008, 39(3):983-990. doi: 10.1161/STROKEAHA.107.499079
[30]	Lemasters J J. Selective mitochondrial autophagy, or mitophagy, as a targeted defense against oxidative stress, mitochondrial dysfunction, and aging[J]. Rejuvenation Res, 2005, 8(1):3-5. doi: 10.1089/rej.2005.8.3
[31]	Tobaben S, Grohm J, Seiler A, et al. Bid-mediated mitochondrial damage is a key mechanism in glutamate-induced oxidative stress and AIF-dependent cell death in immortalized HT-22 hippocampal neurons[J]. Cell Death Differ, 2011, 18(2):282-292. doi: 10.1038/cdd.2010.92 pmid: 20689558
[32]	Dagda R K, Cherra S J 3rd, Kulich S M, et al. Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fission[J]. J Biol Chem, 2009, 284(20):13843-13855. doi: 10.1074/jbc.M808515200
[33]	Zhang X, Yan H, Yuan Y, et al. Cerebral ischemia-reperfusion-induced autophagy protects against neuronal injury by mitochondrial clearance[J]. Autophagy, 2013, 9(9):1321-1333. doi: 10.4161/auto.25132
[34]	Dikic I, Elazar Z. Mechanism and medical implications of mammalian autophagy[J]. Nat Rev Mol Cell Biol, 2018, 19(6):349-364. doi: 10.1038/s41580-018-0003-4
[35]	Ordureau A, Harper J W. Cell biology: balancing act[J]. Nature, 2014, 510(7505):347-348. doi: 10.1038/nature13500 pmid: 24896184
[36]	Shi R Y, Zhu S H, Li V, et al. BNIP3 interacting with LC3 triggers excessive mitophagy in delayed neuronal death in stroke[J]. CNS Neurosci Ther, 2014, 20(12):1045-1055.
[37]	Bauvy C, Gane P, Arico S, et al. Autophagy delays sulindac sulfide-induced apoptosis in the human intestinal colon cancer cell line HT-29[J]. Exp Cell Res, 2001, 268(2):139-149. pmid: 11478840
[38]	Qi Z, Dong W, Shi W, et al. Bcl-2 phosphorylation triggers autophagy switch and reduces mitochondrial damage in limb remote ischemic conditioned rats after ischemic stroke[J]. Transl Stroke Res, 2015, 6(3):198-206. doi: 10.1007/s12975-015-0393-y
[39]	Baek S H, Noh A R, Kim K A, et al. Modulation of mitochondrial function and autophagy mediates carnosine neuroprotection against ischemic brain damage[J]. Stroke, 2014, 45(8):2438-2443. doi: 10.1161/STROKEAHA.114.005183
[40]	周密. Parkin/DJ-1调控的线粒体自噬在远端缺血后处理减轻大鼠局灶性脑缺血再灌注损伤中的作用[D]. 武汉: 武汉大学, 2016.
	Zhou M. Role of mitoghagy regulated by Parkin/DJ-1 in remote ischemic postconditioning-induced mitigation of focal cerebral ischemia-reperfusion injury in rats[D]. Wuhan: Wuhan University, 2016.
[41]	Inoue I, Nagase H, Kishi K, et al. ATP-sensitive K⁺ channel in the mitochondrial inner membrane[J]. Nature, 1991, 352(6332):244-247. pmid: 1857420
[42]	Wang J K, Wu H F, Zhou H. Postconditioning with sevoflurane protects against focal cerebral ischemia,and,reperfusion,injury,involving mitochondrial ATP-dependent potassium channel and mitochondrial permeability transition pore[J]. Neurol Res, 2015, 37(1):77-83. doi: 10.1179/1743132814Y.0000000410
[43]	Murata M, Akao M, O'rourke B, et al. Mitochondrial ATP-sensitive potassium channels attenuate matrix Ca(2+) overload during simulated ischemia and reperfusion: possible mechanism of cardioprotection[J]. Circ Res, 2001, 89(10):891-898. pmid: 11701616
[44]	韩林, 高旸, 王旭慧, 等. “醒脑开窍”针刺法调节ATP敏感性钾通道开放对抗脑缺血再灌注损伤的机制研究[J]. 中国针灸, 2018, 38(12):1319-1324.
	Han L, Gao Y, Wang X H, et al. Mechanism of "Xingnao Kaiqiao" acupuncture for the opening of ATP sensitive potassium channel against cerebral ischemia reperfusion injury in rats[J]. Chin Acupun Moxib, 2018, 38(12):1319-1324.
[45]	Bajgar R, Seetharaman S, Kowaltowski A J, et al. Identification and properties of a novel intracellular (mitochondrial) ATP-sensitive potassium channel in brain[J]. J Biol Chem, 2001, 276(36):33369-33374. pmid: 11441006
[46]	张俊杰, 顾虎, 李士通, 等. 线粒体ATP敏感性钾通道开放预防脑缺血-再灌注引起的神经细胞凋亡[J]. 临床麻醉学杂志, 2004, 20(7):420-422.
	Zhang J J, Gu H, Li S T, et al. Mitochondrial ATP-sensitive potassium channel opening prevents neuron apoptosis induced by cerebral ischemia-reperfusion[J]. J Clinl Anesth, 2004, 20(7):420-422.
[47]	鹿欣, 陈克彪, 马磊, 等. 二氮嗪后处理联合预处理对心肌缺血再灌注损伤作用的研究[J]. 泰山医学院学报, 2011, 32(12):893-896.
	Lu X, Chen K B, Ma L, et al. Study on the effect of diazoxide postconditioning combined with diazoxide preconditioning on myocardial ischemia/reperfusion injury[J]. J Taishan Med Colleg, 2011, 32(12):893-896.
[48]	吴莉萍. 线粒体ATP敏感性钾通道介导肢体缺血后处理对抗大鼠局灶性脑缺血再灌注损伤的神经保护作用[D]. 杭州:浙江大学, 2006.
	Wu L P. Mitochondrial ATP sensitive potassium channel mediates the neuroprotective effect of limb ischemic post-conditioning on rat brain ischemia and reperfusion injury[D]. Hangzhou: Zhejiang University, 2006.
[49]	Sun J, Tong L, Luan Q, et al. Protective effect of delayed remote limb ischemic postconditioning: role of mitochondrial K(ATP) channels in a rat model of focal cerebral ischemic reperfusion injury[J]. J Cereb Blood Flow Metab, 2012, 32(5):851-859. doi: 10.1038/jcbfm.2011.199
[50]	Di Lisa F, Bernardi P. A CaPful of mechanisms regulating the mitochondrial permeability transition[J]. J Mol Cell Cardiol, 2009, 46(6):775-780. doi: 10.1016/j.yjmcc.2009.03.006
[51]	李富强, 白宏英, 娄季宇, 等. 脑缺血后处理对缺血再灌注脑组织线粒体通透性转换的影响[J]. 中风与神经杂志, 2011, 28(9):796-799.
	Li F Q, Bai H Y, Lou J Y, et al. Effect of cerebral ischemic postconditioning on mitochondrial permeability transition in ischemic reperfusion brain tissue[J]. J Stroke Nerv, 2011, 28(9):796-799.
[52]	Argaud L, Gateau-Roesch O, Raisky O, et al. Postconditioning inhibits mitochondrial permeability transition[J]. Circulation, 2005, 111(2):194-197. doi: 10.1161/01.CIR.0000151290.04952.3B
[53]	卢英云. 缺血后处理对糖尿病大鼠局灶性脑缺血再灌注损伤线粒体功能的影响[D]. 济南:山东大学, 2008.
	Lu Y Y. Role of mitochondrial in ischemic postconditioning-induced attenuation of cerebral ischemia in diabetic rats[D]. Jinan: Shandong University, 2008.

Advance in Role of Mitochondria in Remote Ischemic Postconditioning for Cerebral Ischemia-reperfusion Injury (review)

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