脑皮质梗死慢性期非流利性失语症灰质体积的改变

doi:10.3969/j.issn.1006-9771.2021.00.003

Abstract

Abstract:

Objective To investigate the changes of gray matter volume in patients with chronic nonfluent aphasia after cortical cerebral infarction and the relationship between gray matter volume and language function.

Methods From June, 2016 to June, 2019, 19 patients with chronic nonfluent aphasia after cortical cerebral infarction from the First Affiliated Hospital of Ji'nan University and 28 healthy subjects (controls) were scanned with structural magnetic resonance imaging. The data were analyzed using voxel-based morphological measurement to measure the gray matter volumes of the brain regions, and the differences between patients and controls were compared. The correlation between volumes of brain regions with difference and scores of items of Aphasia Battery of Chinese (ABC) was analyzed.

Results The gray matter volumes increased in the brain regions of right inferior frontal gyrus triangle, right inferior frontal gyrus island cover, right angular gyrus, the right medial frontal gyrus, left insula, left medial frontal gyrus in the patients; while decreased in right globus pallidus. The volumes of left insular lobe correlated with the scores of repeating (r = 0.665, P = 0.001) and naming (r = 0.638, P = 0.003); and the volumes of right inferior frontal gyrus triangle correlated with the scores of hearing comprehension (r = 0.493, P = 0.031), repeating (r = 0.576, P = 0.009) and naming (r = 0.674, P = 0.001) in the patients.

Conclusion The cortex volumes of left insula and right inferior frontal gyrus triangle increase in patients with chronic nonfluent aphasia after cerebral infarction, which may play a role in the language dysfunction.

Key words: cerebral infarction, aphasia, structural magnetic resonance imaging, voxel-based morphological measurement, gray matter volume

CLC Number:

R743.32

DAI Yan-hong, HUANG Jia-ying, LUO Hai-long, WANG Rui-qing, HUANG Ying-an, CHEN Zhuo-ming, WANG Hong. Changes in Gray Matter Volume in Chronic Nonfluent Aphasia after Cortical Cerebral Infarction[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2021, 27(7): 785-790.

Figures/Tables 4

References 37

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特征	对照组 (n = 28)	患者组 (n = 19)	χ²/t/Z值	P值
性别(男/女, n)	15/13	12/7	0.426	0.514^a
年龄(岁)	54.86±4.66	55.21±5.57	0.231	0.353^b
教育程度(年)	9.46±2.36	9.55±2.68	0.242	0.821^c
病程(月)	–	8.68±2.12

脑区	体素数	MNI坐标			t值
脑区	体素数	X	Y	Z	t值
左岛叶	22	-36	16	0	-4.229
左内侧额上回	104	-4	16	52	-5.158
右额下回三角部	33	48	24	4	-5.046
右岛盖部额下回	11	52	12	24	-3.784
右角回	53	52	-56	36	-5.144
右内侧额上回	104	4	16	52	-5.158
右侧苍白球	22	28	-8	-4	4.718

Changes in Gray Matter Volume in Chronic Nonfluent Aphasia after Cortical Cerebral Infarction

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