Netrin-1对脑梗死损伤的保护和修复作用研究进展

doi:10.3969/j.issn.1006-9771.2021.03.011

Abstract

Abstract:

Netrin-1 may protect and repair the damage caused by cerebral infarction, in terms of inhibiting apoptosis and inflammatory, and promoting angiogenesis and axon regeneration, etc. Netrin-1 may associate with the pathogenesis and outcome of cerebral infarction. The application of Netrin-1 in clinic needs more researches.

Key words: cerebral infarction, Netrin-1, apoptosis, inflammatory, angiogenesis, axon regeneration, review

CLC Number:

R743.32

Xin-yu ZHANG,Xiao-zheng DU,Jin-hai WANG,Wen-jie HE,Na-na WANG,Ruo-zhou WANG,Wei-yao JING,Shang-wei YANG. Advance of Netrin-1 for Protection and Repairment of Injuries after Cerebral Infarction (review)[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2021, 27(3): 316-319.

References 41

1	Mozaffarian D, Benjamin E J, Go A S, et al. Executive summary: Heart Disease and Stroke Statistics-2016 update: a report from American Heart Association [J]. Circulation, 2016, 133 (4): 447-454.
2	Podjaski C, Alvarez J I, Bourbonniere L, et al. Netrin-1 regulates blood-brain barrier function and neuroinflammation [J]. Brain, 2015, 138(6): 1598-1621.
3	Chen J, Xuan Y, Chen Y, et al. Netrin-1 alleviates subarachnoid haemorrhage-induced brain injury via the PPARγ/NF-KB signaling pathway [J]. J Cell Mol Med, 2019, 23(3): 2256-2262.
4	Zhan Y, Li M Z, Yang L, et al. An MRI study of neurovascular restorative after combination treatment with Xiaoshuan enteric-coated capsule and enriched environment in rats after stroke [J]. Front Neurosci, 2019, 9(13): 701.
5	Zheng M, Chen R, Chen H, et al. Netrin-1 promotes synaptic formation and axonal regeneration via JNK1/c-JUN pathway after the middle cerebral artery occlusion [J]. Front Cell Neurosci, 2018, 13(12): 13.
6	Gopal A A, Rappaz B, Rouger V, et al. Netrin-1-regulated distribution of UNC5B and DCC in live cells revealed by TICCS [J]. Biophys J, 2016, 110(3): 623-634.
7	Forcet C, Stein E, Pays L, et al. Netrin-1-mediated axon outgrowth requires deleted in colorectal cancer-dependent MAPK activation [J]. Nature, 2001, 417(6687): 443-447.
8	Dalvin S, Anselmo M A, Prodhan P, et al. Expression of netrin-1 and its two receptors DCC and UNC5H2 in the developing mouse lung [J]. Gene Expr Patterns, 2003, 3(3): 279-283.
9	Grandin M, Meier M, Delcros J G, et al. Structural decoding of the Netrin-1/UNC5 interaction and its therapeutical implications in cancers [J]. Cancer Cell, 2016, 29(2): 173-185.
10	An X Z, Zhao Z G, Luo Y X, et al. Netrin-1 suppresses the MEK/ERK pathway and ITGB4 in pancreatic cancer [J]. Oncotarget, 2016, 7(17): 24719-24733.
11	Liao S J, Gong Q, Chen X R, et al. Netrin-1 rescues neuron loss by attenuating secondary apoptosis in ipsilateral thalamic nucleus following focal cerebral infarction in hypertensive rats [J]. Neuroscience, 2013, 12(231): 225-232.
12	Ranganathan P V, Jayakumar C, Ramesh G. Netrin-1-treated macrophages protect the kidney against ischemia-reperfusion injury and suppress inflammation by inducing M2 polarization [J]. Am J Physiol Renal Physiol, 2013, 304(7): F948-F957.
13	Keino-Masu K, Masu M, Hinck L, et al. Deleted in colorectal cancer (DCC) encodes a netrin receptor [J]. Cell, 1996, 87(2): 175-185.
14	Tu T, Zhang C, Yan H, et al. CD₁₄₆ acts as a novel receptor for netrin-1 in promoting angiogenesis and vascular development [J]. Cell Res, 2015, 25(3): 275-287.
15	Chen J, Du H, Zhang Y, et al. Netrin-1 prevents rat primary cortical neurons from apoptosis via the DCC/ERK pathway [J]. Front Cell Neurosci, 2017, 13(11): 387.
16	Douglas T, Saleh M. Post-translational modification of OTULIN regulates ubiquitin dynamics and cell death [J]. Cell Rep, 2019, 29(11): 3652-3663.
17	Paradisi A, Creveaux M, Gibert B, et al. Combining chemotherapeutic agents and netrin-1 interference potentiates cancer cell death [J]. EMBO Mol Med, 2013, 5(12): 1821-1834.
18	Llambi F, Causeret F, Bloch-Gallego E, et al. Netrin-1 acts as a survival factor via its receptors UNC5H and DCC [J]. EMBO J, 2001, 20(11): 2715-2722.
19	Liu H, Jia D, Li A, et al. P53 regulates neural stem cell proliferation and differentiation via BMP-Smad1 signaling and ld1 [J]. Stem Cells Dev, 2013, 22(6): 913-927.
20	Ranganathan P, Jayakumar C, Navankasttusas S, et al. UNC5B receptor deletion exacerbates tissue injury in response to AKI [J]. J Am Soc Nephrol, 2014, 25(2): 239-249.
21	Cheyuo C, Aziz M, Yang W L, et al. Milk fat globule-EGF factor VIII attenuates CNS injury by promoting neural stem cell proliferation and migration after cerebral ischemia [J]. PLoS One, 2015, 10(4): e0122833.
22	Qu C, Li W, Shao Q, et al. C-Jun N-terminal kinase 1 (JNK1) is required for coordination of netrin signaling in axon guidance [J]. J Biol Chem, 2013, 288(3): 1883-1895.
23	Wang P, Zhang J, Guo F, et al. Lipopolysaccharide worsens the prognosis of experimental cerebral ischemia via interferon gamma-induced protein 10 recruit in the acute stage [J]. BMC Neurosci, 2019, 20(1): 64.
24	Zhao X R, Gonzales N, Aronowski J. Pleiotropic role of PPARγ in intracerebral hemorrhage: an intricate system involving Nrf2, RXR, and NF-kB [J]. CNS Neurosci Ther, 2015, 21(4): 357-366.
25	Xie Z, Huang L, Enkhjargal B, et al. Recombinant netrin-1 binding UNC5B receptor attenuates neuroinflammation and brain injury via PPARγ/NF-kB signaling pathway after subarachnoid hemorrhage in rats [J]. Brain Behav Immun, 2018, 69(5): 190-202.
26	He X, Liu Y, Lin X, et al. Netrin-1 attenuates brain injury after middle cerebral artery occlusion via downregulation of astrocyte activation in mice [J]. J Neuroinflammation, 2018, 15(1): 268.
27	Liu J, Wang Y, Akamatsu Y, et al. Vascular remodeling after ischemic stroke: mechanisms and therapeutic potentials [J]. Prog Neurobiol, 2014, 115(4): 138-156.
28	罗春云,贺小松. Netrin-1促进脑缺血康复的作用机制研究[J]. 现代医院, 2017, 5(17): 710-712, 715.
	Luo C Y, He X S. Study of NT-1 in promoting the recovery mechanism in MCAO model [J]. Moder Hosp, 2017, 5(17): 710-712, 715.
29	Lu H, Wang Y, He X, et al. Netrin-1 hyperexpression in mouse brain promotes angiogenesis and long-term neurological recovery after transient focal ischemia [J]. Stroke, 2012, 43(3): 838-843.
30	Liu N M, Sui K L, Youn J Y, et al. Attenuation of neointimal formation with netrin-1 and netrin-1 preconditioned endothelial progenitor cells [J]. J Mol Med (Berl), 2017, 95(3): 335-348.
31	Larrivee B, Freitas C, Trombe M, et al. Activation of the UNC5B receptor by netrin-1 inhibits sprouting angiogenesis [J]. Cened Dev, 2007, 21(19): 2433-2447.
32	Han X F, Zhang Y, Xiong L L, et al. Erratum to: Lentiviral-mediated netrin-1 overexpression improves motor and sensory functions in SCT rats associated with SYP and GAP-43 expressions [J]. Mol Neurobiol, 2017, 54(3): 1684-1697.
33	Sakumura Y, Tsukada Y, Yamaoto N, et al. A molecular model for axon guidance based on cross talk between rho GTPases [J]. Biophys J, 2005, 89(2): 812-822.
34	Mi Z, Si T, Kapadia K, et al. Receptor-stimulated transamidation induces activation of Rac1 and Cdc42 and the regulation of dendritic spines [J]. Neuropharmacology, 2017, 1(5): 93-105.
35	Shabani M, Haghani M, Tazangi P E, et al. Netrin-1 improves the amyloid-β-mediated suppression of memory and synaptic plasticity [J]. Brain Res Bull, 2017, 131(5): 107-116.
36	陆跃,刘建红,赵晖,等. 侯氏黑散对脑缺血大鼠神经导向因子及Rho GTP酶的影响[J]. 首都医科大学学报, 2017, 6(38): 891-896.
	Lu Y, Liu J H, Zhao H, et al. Influence of Houshiheisan on the expression of axon guidance factor and Rho GTPases [J]. J Capital Med Univ, 2017, 6(38): 891-896.
37	Oksala N, Parssinen J, Seppala I, et al. Association of neuroimmune guidance cue netrin-1 and its chemorepulsive receptor UNC5B with atherosclerotic plaque expression signatures and stability in human(s): Tampere Vascular Study (TVS) [J]. Circ Cardiovasc Genet, 2013, 6(6): 579-587.
38	Ivelik K, Koylu R, Akinci E,et al. Determination of netrin-1 levels in patients that applied to emergency department with stroke and its effects on survival for 6 months [J]. J Emerg Med, 46(2): 281-282.
39	Guo D, Zhu Z, Zhong C, et al. Increased serum netrin-1 is associated with improved prognosis of ischemic stroke [J]. Stroke, 2019, 50(4): 845-852.
40	Chen D, Huang X, Lu S, et al. RBP4/Lp-PLA₂/Netrin-1 signaling regulation of cognitive dysfunction in diabetic nephropathy complicated with silent cerebral infraction [J]. Exp Clin Endocrinol Diabetes, 2017, 125(8): 547-553.
41	吕凯,李凤,龚标,等. 电针对轴突生长导向因子-1和臂板蛋白3a在局灶性脑梗死大鼠脑皮质表达的影响[J]. 第三军医大学学报, 2013, 18(35): 1941-1946.
	Lü K, Li F, Gong B, et al. Effect of electro-acupuncture on expression of netrin-1 and semaphorin 3a in rat cortex after middle cerebral occlusion [J]. Acta Acad Med Milit Tert, 2013, 18(35): 1941-1946.

[1]	SHAO Weiting, LEI Jianghua. Effect of response interruption and redirection as a behavioral intervention on vocal stereotypy in children with autism spectrum disorder: a scoping review [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2024, 30(1): 10-20.
[2]	WANG Hangyu, GE Keke, FAN Yonghong, DU Lilu, ZOU Min, FENG Lei. Effect of active music therapy on cognitive function for older adults with cognitive impairment: a systematic review based on ICD-11 and ICF [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2024, 30(1): 36-43.
[3]	WEN Jianing, JIN Qiuyan, ZHANG Qi, LI Jie, SI Qi. Effect of cognitively engaging physical activity on developing executive function of children and adolescents: a systematic review based on ICF [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2024, 30(1): 44-53.
[4]	GE Keke, FAN Yonghong, WANG Hangyu, DU Lilu, LI Changjiang, ZOU Min. Health benefit of mindfulness intervention for older adults with insomnia disorders: a systematic review [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2024, 30(1): 54-60.
[5]	ZHANG Jingya, ZOU Min, SUN Hongwei, SUN Changlong, ZHU Juntong. Effect of psychological intervention on anxiety or depression in children and adolescents with hearing impairment: a systematic review [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2023, 29(9): 1004-1011.
[6]	WANG Junyu, YANG Yong, YUAN Xun, XIE Ting, ZHUANG Jie. Effect of high-intensity interval training on executive function for healthy children and adolescents: a systematic review [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2023, 29(9): 1012-1020.
[7]	WEI Xiaowei, YANG Jian, WEI Chunyan. Psychological and behavioral benefits of adapted yoga exercise for children with autism spectrum disorder in special education schools: a systematic review [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2023, 29(9): 1021-1028.
[8]	YANG Yaru, YANG Jian. School-based physical activity-related health services and their health benefits within the World Health Organization health-promoting school framework: a systematic review of systematic reviews [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2023, 29(9): 1040-1047.
[9]	WANG He, HAN Liang, KAN Mengfan, YU Shaohong. Efficacy of electrical stimulation on shoulder-hand syndrome after stroke: a systematic review and meta-analysis [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2023, 29(9): 1048-1056.
[10]	SHI Jiawei, LI Lingyu, YANG Haojie, WANG Qinlu, ZOU Haiou. Effect of preoperative prerehabilitation training on total knee arthroplasty: a systematic review of systematic reviews [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2023, 29(9): 1057-1064.
[11]	JIANG Changhao, HUANG Chen, GAO Xiaoyan, DAI Yuanfu, ZHAO Guoming. Effect of neurofeedback training on cognitive function in the elderly: a systematic review [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2023, 29(8): 903-909.
[12]	WEI Xiaowei, YANG Jian, WEI Chunyan, HE Qiling. Adapted physical education programs for psychomotor development in school settings for children with intellectual and developmental disabilities: a systematic review [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2023, 29(8): 910-918.
[13]	ZHANG Yuan, YANG Jian. School health services and effectiveness based on World Health Organization health-promoting school framework: a scoping review [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2023, 29(7): 791-799.
[14]	WANG Shaopu, CHEN Gang. Psychological-behavioral health services and its outcome based on World Health Organization health-promoting school framework: a systematic review of systematic reviews [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2023, 29(7): 800-807.
[15]	JIANG Changhao, GAO Xiaoyan. Effect of acute physical activity on cognitive function in children: a systematic review [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2023, 29(6): 667-672.

Advance of Netrin-1 for Protection and Repairment of Injuries after Cerebral Infarction (review)

RichHTML

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References 41

Related Articles 15

Metrics

Comments

Recommended 0