慢性病患者参与药物临床试验意愿的影响因素：医学伦理观念调查

doi:10.3969/j.issn.1006-9771.2021.03.018

Abstract

Abstract: Objective

To investigate the medical ethics and willingness to participate in pharmacological clinical trials of patients with chronic diseases, and explore the related factors.

Methods

In December, 2020, 318 patients with chronic diseases from the Department of Internal Medicine, Beijing Bo'ai Hospital were investigated with a self-made medical ethics questionnaire for the items of medical ethics and willingness to participate in pharmacological clinical trials.

Results

The attention to medical knowledge, awareness of their rights and responsibilities were various with the courses of disease, educational levels and resident areas. The satisfaction for treatment and trust to the doctors were related with the willingness to participate in pharmacological clinical trials by multivariate Logistic regression (P < 0.05). The patients in trials paid the most attention to the safety of the trail, and then the therapeutic effect.

Conclusion

Promoting and protecting the medical rights, improving the trust to doctors, strengthening the publicity of clinical trial knowledge, may promote the willingness to participate in pharmacological clinical trials of patients with chronic diseases.

Key words: pharmacological clinical trials, willingness, medical ethics

CLC Number:

R969.4

Mei-xin LI,Xin ZHENG,Wen-li SHI,Zhi-qing LIU,Jing-jie HE. Factors Related with Willingness to Participate in Pharmacological Clinical Trials of Patients with Chronic Diseases: Investigation of Medical Ethics[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2021, 27(3): 361-367.

Figures/Tables 6

References 36

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变量		n	赋值
性别	男	129	1
性别	女	189	2
婚姻	已婚	234	1
	未婚	16	2
	离异	33	3
	丧偶	35	4
文化程度	初中及以下	70	1
	高中或专科	146	2
	本科	87	3
	研究生	15	4
宗教信仰	有	0	1
宗教信仰	无	318	2
支付类型	公费	56	1
	医保	209	2
	农村合作医疗	35	3
	自费	18	4
病程	< 5年	88	1
	5~10年	97	2
	> 10年	133	3
地域	城市	270	1
	农村	27	2
	流动人口	21	3

变量(赋值)		< 5年	5~10年	> 10年	χ²值	P值
医学知识关注度	从不关注(= 1)	5	32	29	13.232	0.010
	偶尔关注(= 2)	43	44	39
	非常关注(= 3)	40	21	65
家庭支持	非常支持(= 1)	66	90	117	6.859	0.032
	一般(= 2)	22	7	16
患者权益和责任认知度	完全认知(= 1)	42	18	48	9.237	0.048
	部分知道(= 2)	38	71	65
	不知道(= 3)	8	8	20
治疗效果满意度	满意(= 1)	65	78	105	2.617	0.722
	一般满意(= 2)	20	17	25
	不满意(= 3)	3	2	3
医生信任度	非常不信任(= 1)	0	0	0	2.339	0.311
	有些不信任(= 2)	0	0	0
	说不清楚(= 3)	24	42	42
	比较信任(= 4)	59	51	85
	非常信任(= 5)	5	4	6
自我管理能力	非常好(= 1)	74	83	113	1.945	0.936
	一般(= 2)	13	12	15
	较差(= 3)	1	2	5

变量(赋值)		城市	农村	流动人口	χ²值	P值
治疗效果满意度	满意(= 1)	221	10	17	12.651	0.008
	一般满意(= 2)	42	16	4
	不满意(= 3)	7	1	0
患者权益和责任认知度	完全认知(= 1)	89	4	15	24.523	< 0.001
	部分知道(= 2)	162	10	2
	不知道(= 3)	19	13	4
医生信任度	非常不信任(= 1)	0	0	0	2.650	0.321
	有些不信任(= 2)	0	0	0
	说不清楚(= 3)	91	14	3
	比较信任(= 4)	175	7	13
	非常信任(= 5)	4	6	5

项目	B	SE	Wald	P值	Exp(B)
医生信任度	1.922	0.339	32.082	< 0.001	0.146
治疗效果满意度	-0.399	0.183	4.737	0.030	1.491

Factors Related with Willingness to Participate in Pharmacological Clinical Trials of Patients with Chronic Diseases: Investigation of Medical Ethics

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