基于PubMed数据库骶神经刺激疗法的临床研究特征分析

doi:10.3969/j.issn.1006-9771.2021.04.015

Abstract

Abstract: Objective

To analyze the clinical studies on sacral nerve stimulation based on PubMed database and summarize its research status and clinical characteristics.

Methods

Literatures about sacral nerve stimulation were collected from PubMed database before December 31, 2019. HistCite software was used to analyze the published year, published periodicals, published country and research institutions. Pajek software principal path analysis was used to identify the evolution direction of hot topics. The spectrum of diseases, therapeutic outcomes, stimulation methods and stimulation parameters were summarized.

Results

A total of 96 articles were included. The number of publications increased significantly since 2000 and reached its peak in 2014 to 2015. The literatures with most influence were published in 2000 to 2001. All the literatures published in 32 journals, the top two were Urology and Diseases of the Colon & Rectum, which published 17 and 22 articles, respectively. The literatures came from 16 countries, and the top three were the United State (17 articles), the Netherlands (13) and the United Kingdom (13). Among the 211 institutes involved, Aarhus University Hospital (Denmark, twelve articles) and St. Marks Hospital (United Kingdom, nine) were the top two. The study involved 16 diseases, mainly about fecal incontinence, urinary incontinence and urination, shifted from urinary system diseases to digestive system diseases. 91.67% of the study corroborated the benefit of sacral nerve stimulation. Implanted stimulation (77 articles) was the most used, and transdermal stimulation (10 articles) was the second. The parameters were depending on the disease and the mode of stimulation.

Conclusion

Sacral nerve stimulation can effectively improve the function of pelvic floor, which may be focused for a long time. Non-implantable sacral nerve stimulation would become the new research topic.

Key words: sacral nerve stimulation, PubMed database, clinical research, bibliometrics

CLC Number:

R493

Jia-yuan ZHENG,Jing JIANG,Chen-lei QIAN,Jia-ming HU,Yi ZHUANG,Sheng-feng LU. Analysis of Characteristics of Clinical Researches on Sacral Nerve Stimulation Based on PubMed Database[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2021, 27(4): 487-496.

Figures/Tables 9

期刊名称	文章题目	第一作者	第一作者研究机构 (国家)	出版年份	影响因子	治疗疾病	刺激部位	治疗方法
Lancet	Sacral spinal nerve stimulation for faecal incontinence: multicentre study	Matzel K E	埃尔兰根大学医院普通外科(德国)	2004	59.102	大便失禁	骶神经	植入性频率15 Hz，脉宽210 ms，平均刺激36个月
Gastroenterology	Sacral nerve stimulation as a treatment for fecal incontinence	Rosen H R	多瑙河医院外科路德维希波兹曼肿瘤外科研究所(奥地利)	2001	19.233	大便失禁	S₂~S₄骶神经根	植入性频率20 Hz，脉宽210 ms电压1.5~4.5 V，平均刺激6个月
Gut	Sacral nerve stimulation for intractable constipation	Kamm M A	维多利亚大学医学院圣文森特医院(澳大利亚)	2010	17.943	便秘	骶神经	植入性频率14 Hz，脉宽210 ms，连续低振幅刺激3周
European Urology	Sacral neuromodulation for women with Fowler's syndrome	Swinn M J	国家神经内科和神经外科医院(英国)	2000	17.298	福勒斯综合征	骶神经	植入性永久刺激
European Urology	Long-term effectiveness of sacral nerve stimulation for refractory urge incontinence	Janknegt R A	马斯特里赫特学院(荷兰)	2001	17.298	尿失禁	单侧刺激S₃/S₄骶神经根	植入性平均刺激(30.8±14.8)个月(12~60个月)
American Journal of Gastroenterology	Treatment efficacy of sacral nerve stimulation in slow transit constipation: a two-phase, double-blind randomized controlled crossover study	Dinning P G	新南威尔士大学临床学院医学院圣乔治医院(澳大利亚)	2015	10.241	便秘	骶神经	永久性植入频率14 Hz，脉宽300 ms，振幅缓慢增加，直到患者感知到刺激，然后降低0.2 V
Annals of Sugery	Efficacy of sacral nerve stimulation for fecal incontinence: results of a multicenter double-blind crossover study.	Leroi A M	楚鲁昂消化道研究组(法国)	2005	9.476	大便失禁	骶神经	植入性频率14 Hz，脉宽210 ms，平均刺激2个月
Annals of Sugery	Sacral nerve stimulation for fecal incontinence: results of a 120-patient prospective multicenter study	Wexner S D	佛罗里达州劳德代尔堡克利夫兰诊所结直肠外科(美国)	2010	9.476	大便失禁	刺激S₂、S₃或S₄骶神经根	植入性频率15 Hz，脉宽210 ms，刺激电压通常高于患者感觉肌肉收缩时，平均刺激12个月
Annals of Sugery	Prospective randomized double-blind study of temporary sacral nerve stimulation in patients with rectal evacuatory dysfunction and rectal hyposensitivity.	Knowles C H	玛丽女王大学外科中心学术部消化疾病中心(英国)	2012	9.476	直肠排空功能障碍直肠低敏感性	S₃骶神经根	植入性频率15 Hz，脉宽210 ms，振幅0.5~10 V，成功经皮刺激评估后，提供永久刺激
Annals of Sugery	A randomized, controlled, crossover study of sacral nerve stimulation for irritable bowel syndrome	Fassov J L	奥尔胡斯大学医院肝脏和消化内科及外科(丹麦)	2014	9.476	肠易激综合征	S₃或S₄骶神经根	植入性频率14 Hz，脉宽210 ms平均脉冲幅度1.0 V (0.1~4 V)，永久刺激

治疗疾病	治疗方式	刺激部位	治疗参数
大便失禁	植入式	S₂、S₃或S₄骶神经根	频率5~31 Hz，以14 Hz最多；脉冲宽度90~330 ms，以210 ms最多；平均波幅0.5~10 V；平均刺激时间2周~60个月
大便失禁	经皮式	S₂~S₄水平的皮肤上	频率10 Hz；脉宽200 ms；每天刺激时间2 h，共持续10个月
尿失禁	植入式	S₃或S₄骶神经根	频率5~15 Hz，以10 Hz最多；脉宽100~210 ms，以210 ms最多；平均波幅1~2.8 V；平均电流强度0.5~20 mA；刺激时间6 d~60个月，以6个月最多见
	经皮式	S₂~S₃水平的皮肤上	频率10~75 Hz，以10 Hz最多；脉宽150~200 ms，以200 ms最多；电流强度为患者能忍受的最大限度，最大为40 mA，每天刺激1次，持续30 min，连续刺激90 d
	磁刺激	骶神经根	频率5 Hz；强度输出50%；刺激时间为每分钟5 s，持续30 min，共刺激1周
排尿障碍	植入式	S₃或S₄骶神经根	频率33 Hz；平均波幅2~10 V；平均电流强度为0.5~10 mA，刺激时间4 d~5年，以7 d和3~18个月最多见
便秘	植入式	S₃骶神经根	频率7.5~15 Hz，以14 Hz最多；脉宽210~300 ms，以210 ms最多；波幅为0.1~10 V，以0.2~2.8 V最多；刺激时间2 d~1年，以3~5周最多见
便秘	经皮式	S₃水平的皮肤上	频率10 Hz；脉宽200 ms；刺激时间为每天2 h，持续1个月
尿频尿急	植入式	S₁~S₄骶神经根	频率10 Hz或15 Hz；脉宽200 ms；短期刺激时间平均为3周；长期刺激平均2年
	磁刺激	骶神经根	频率15 Hz；强度输出50%；刺激时间为每分钟5 s，持续30 min，共刺激1周
	电针	4个骶骨穴；上两点位于骶尾部关节两侧约1 cm处。两个较低点的位置在尾骨顶端两侧约1 cm处	频率2 Hz；脉宽2 ms；平均电流强度为25~35 mA；每次刺激时间60 min；持续刺激16个月
膀胱过度活动	植入式	S₃或S₄骶神经根	频率20 Hz；脉宽210 ms；平均刺激时间4周
膀胱过度活动	磁刺激	骶神经根	频率5~20 Hz；脉宽1 ms；产生200 G的磁场；每天刺激20 min，持续12周
间质性膀胱炎	植入式	S₃或S₄骶神经根	频率16 Hz；脉宽200 ms；平均刺激时间6个月
	经皮式	S₃水平的皮肤上	频率15 Hz；脉宽210 ms；平均波幅为0~10 V；平均刺激时间7~14 d
	电针	腹四穴、骶四穴左右两穴分别连接成电极	频率2~2.5 Hz；刺激强度为患者感觉舒适为准；平均刺激时间3个月
慢性盆腔疼痛综合征	植入式	S₃骶神经根	频率18~25 Hz；脉宽210 ms；振幅略高于患者感觉阈值；平均刺激时间4周
肠易激综合征	植入式	S₃或S₄骶神经根	频率10 Hz或14 Hz；脉宽210 ms；平均波幅为0.1~4 V；平均刺激时间1个月
单症状性夜间遗尿症	磁刺激	骶神经根	频率15 Hz；刺激以10 s开30 s关的方式进行，共有1500个脉冲；重复治疗10次，每周5次，休息2 d
特发性肛门疼痛	植入性	S₃骶神经根	频率18~21 Hz；脉宽210 ms；平均波幅为1~3 V；平均刺激时间15个月
慢性前列腺炎	电针	双侧BL32(次髎)、BL33(中髎)和GB30(环跳)穴	频率4 Hz；电流强度为5~10 mA；每次持续20 min，每周2次，持续6周
功能逆行射精症	针挑疗法	骶丛神经刺激点(双侧，两髂后上棘外下约1-2横指处)、腰1神经旁刺激点(双侧，第1、2腰椎双侧横突末端连线中点)、枕大神经点(双侧，两乳突连线与正中线相交点旁开1.5~2.5 cm，枕动脉内侧)和关元穴	针挑摆动频率为60回/min，每点约2~3 min；手法上以摇摆为主；辨证施治，兼施以实者右旋，虚者左旋，治毕压平针口，涂上碘伏加止血贴；每次治疗25~30 min，每周1次，共9次
慢性肛裂	植入性	骶神经根	频率30 Hz；脉宽180~210 ms；平均波幅为0.8~2.5V；每次20 min，每天3次，持续3周

References 38

1	徐智慧,魏海彬. 骶神经调节技术在排尿功能障碍治疗中的应用与进展[J]. 山东大学学报(医学版), 2018, 56(3): 29-33.
	Xu Z H, Wei H B. Application and progress of sacral neuromodulation in bladder dysfunction [J]. J Shandong Univ (Health Sci), 2018, 56(3): 29-33.
2	Schmidt R A, Bruschini H, Tanagho E A. Sacral root stimulation in controlled micturition. Peripheral somatic neurotomy and stimulated voiding [J]. Invest Urol, 1979, 17(2): 130-134.
3	Tanagho E A. Neural stimulation for bladder control [J]. Semin Neurol, 1988, 8(2): 170-173.
4	袁媛,姜长青,陈玥,等. 神经调控技术的发展与展望[J]. 生命科学仪器, 2018, 16(Z1): 22-30, 72.
	Yuan Y, Jiang C Q, Chen Y, et al. Development and prospect of neuromodulation technology [J]. Life Sci Instrum, 2018, 16(Z1): 22-30, 72.
5	陈正鑫,樊志敏,何蕾,等. 大便失禁新疗法的应用现状[J]. 中国中西医结合消化杂志, 2019, 27(12): 952-955, 961.
	Chen Z X, Fan Z M, He L, et al. Chin J Integr Trad Western Med on Digestion, 2019, 27(12): 952-955, 961.
6	龙盛荣,王越,袁彩虹,等. 胶质瘤治疗热点的文献计量学分析[J]. 现代肿瘤医学, 2019, 27(15): 2665-2670.
	Long S R, Wang Y, Yuan C H, et al. Analysis of literatures on treatment of glioma research [J]. J Modern Oncol, 2019, 27(15): 2665-2670.
7	王群,贾连群,郑思成,等. 基于文献计量学的动脉粥样硬化中西医研究进展可视化分析[J]. 世界中医药, 2019, 14(8): 2166-2176.
	Wang Q, Jia L Q, Zheng S C, et al. Visualization analysis of research progress of traditional Chinese medicine and western medicine in atherosclerosis based on bibliometrics [J]. World Chin Med, 2019, 14(8): 2166-2176.
8	朱笑笑,糜泽花,钱爱兵. 国际卫生技术评估发展路径识别[J]. 医学信息学杂志, 2019, 40(6): 42-48.
	Zhu X X, Mi Z H, Qian A B. Identification of development roadmap of international health technology assessment [J]. J Med Intell, 2019, 40(6): 42-48.
9	Bosch J L, Groen J. Sacral (S3) segmental nerve stimulation as a treatment for urge incontinence in patients with detrusor instability: results of chronic electrical stimulation using an implantable neural prosthesis [J]. J Urol, 1995, 7(1): 504-507.
10	Matzel K E, Kamm M A, Stosser M, et al. Sacral spinal nerve stimulation for faecal incontinence: multicentre study [J]. Lancet, 2004, 363(9417): 1270-1276.
11	Elabbady A A, Hassouna M M, Elhilali M M. Neural stimulation for chronic voiding dysfunctions [J]. J Urol, 1994, 152(6): 2076-2080.
12	Leroi A M, Michot F, Grise P, et al. Effect of sacral nerve stimulation in patients with fecal and urinary incontinence [J]. Dis Colon Rectum, 2001, 44(6): 779.
13	Knowles C H, Thin N, Gill K, et al. Prospective randomized double-blind study of temporary sacral nerve stimulation in patients with rectal evacuatory dysfunction and rectal hyposensitivity [J]. Ann Surg, 2012, 255(4): 643-649.
14	Fassov J, Brock C, Lundby L, et al. Sacral nerve stimulation changes rectal sensitivity and biomechanical properties in patients with irritable bowel syndrome [J]. Neurogastroenterol Motil, 2014, 26(11): 1597-1604.
15	马思明,杨娜娜,范浩,等. 美国SPARC计划对中医针灸研究的挑战与启发[J]. 中国针灸, 2020, 40(4): 439-442, 444.
	Ma S M, Yang N N, Fan H, et al. Challenges and enlightenments of SPARC program on acupuncture and moxibustion researches in China [J]. Chin Acup Moxib, 2020, 40(4): 439-442, 444.
16	王晓宇,于清泉,何伟,等. 从"分子药"到"电子药":SPARC计划和针刺研究[J]. 针刺研究, 2019, 44(3): 157-160, 175.
	Wang X Y, Yu Q Q, He W, et al. From molecular pharmacy to electroceuticals: SPARC program and acupuncture research [J]. Acup Res, 2019, 44(3): 157-160, 175.
17	Swinn M J, Kitchen N D, Goodwin R J, et al. Sacral neuromodulation for women with Fowler's syndrome[J]. Eur Urol, 2000, 38(4): 439-443.
18	Janknegt R A, Hassouna M M, Siegel S W, et al. Long-term effectiveness of sacral nerve stimulation for refractory urge incontinence [J]. Eur Urol, 2001, 39(1): 101-106.
19	Fassov J, Lundby L, Worsoe J, et al. A randomised, controlled study of small intestinal motility in patients treated with sacral nerve stimulation for irritable bowel syndrome [J]. BMC Gastroenterol, 2014, 14(1471): 111-119.
20	Dudding T C, Pares D, Vaizey C J, et al. Sacral nerve stimulation for the treatment of faecal incontinence related to dysfunction of the internal anal sphincter [J]. Int J Colorectal Dis, 2010, 25(5): 625-630.
21	Tsai P Y, Wang C P, Hsieh C Y, et al. Long-term sacral magnetic stimulation for refractory stress urinary incontinence [J]. Arch Phys Med Rehabil, 2014, 95(12): 2231-2238.
22	Wang S, Zhang S, Zhao L. Long-term efficacy of electrical pudendal nerve stimulation for urgency-frequency syndrome in women [J]. Int Urogynecol J, 2014, 25(3): 397-402.
23	陈琦,张建水,周劲松,等. 第三骶后孔的解剖研究及骶神经调控S₃定位装置的研发[J]. 临床泌尿外科杂志, 2019, 34(8): 625-628.
	Chen Q, Zhang J S, Zhou J S, et al. Anatomical study of the third sacral posterior foramen and development of S₃ localization device of the sacral neuromodulation [J]. J Clin Urology (Chin), 2019, 34(8): 625-628.
24	姜劲峰. 体表刺激调节副交感的神经途径与效应[J]. 生理科学进展, 2019, 50(6): 401-406.
	Jiang J F. The neural pathways and therapeutic effects of surficial stimulation on parasympathetic regulation [J]. Prog Physiol Sci, 2019, 50(6): 401-406.
25	徐智慧. 骶神经调控在盆底功能障碍相关下尿路疾病中的应用[J]. 中国医师杂志, 2019, 21(5): 654-657.
	Xu Z H. Application of sacral neuromodulation in lower urinary tract diseases related to pelvic floor dysfunction [J]. J Chin Physcian, 2019, 21(5): 654-657.
26	宋奇翔,许成,刘智勇. 骶神经电调控在女性神经源性下尿路功能障碍治疗中的意义[J]. 中国医师杂志, 2019, 21(5): 661-664.
	Song Q X, Xu C, Liu Z Y. The application of sacral neuromodulation in the treatment of female neurogenic lower urinary tract dysfunction [J]. J Chin Physcian, 21(5): 661-664.
27	Ratto C, Litta F, Parello A, et al. Sacral nerve stimulation is a valid approach in fecal incontinence due to sphincter lesions when compared to sphincter repair [J]. Dis Colo Rectum, 2010, 53(3): 264-272.
28	Caremel R, Damon H, Ruffion A, et al. Can sacral neuromodulation improve minor incontinence symptoms in doubly incontinent patients successfully treated for major incontinence symptoms? [J]. Urology, 2012, 79(1): 80-85.
29	潘钰,宋为群,王茂斌. 磁刺激在脊髓损伤康复中的研究进展[J]. 中国康复医学杂志, 2007, 22(1): 88-90.
	Pan Y, Song W Q, Wang M B. Chin J Rehabil Med, 2007, 22(1): 88-90.
30	樊晓晨,朱昭锦,韩吉龙,等. 电刺激治疗脊髓损伤后神经源性肠道功能障碍的研究进展[J].现代中西医结合杂志, 2018, 27(13): 1469-1473.
	Fan X C, Zhu Z J, Han J L, et al. Modern J Integ Trad Chin Western Med, 2018, 27(13): 1469-1473.
31	陈鸿,姜劲峰,王欣君. 卒中后自主神经功能障碍的诊治进展[J]. 中国康复理论与实践, 2018, 24(3): 296-299.
	Chen H, Jiang J F, Wang X J. Advance in autonomic dysfunction after stroke (review) [J]. Chin J Rehabil Theory Pract, 2018, 24(3): 296-299.
32	Cimpianu C L, Strube W, Falkai P, et al. Vagus nerve stimulation in psychiatry: a systematic review of the available evidence [J]. J Neural Transm, 2017, 124(1): 145-158.
33	Kompelli A R, Jonathan S N, Nguyen S A, et al. The outcomes of hypoglossal nerve stimulation in the management of OSA: a systematic review and meta-analysis [J]. World J Otorhinolaryngol Head Neck Surg, 2019, 5(1): 41-48.
34	Torres-Rosas R, Yehia G, Pena G, et al. Dopamine mediates vagal modulation of the immune system by electroacupuncture [J]. Nat Med, 2014, 20(3):291-295.
35	周芳玲,丁曙晴. 电刺激疗法在大便失禁治疗中的应用[J]. 胃肠病学, 2019, 24(8): 509-512.
	Zhou F L, Ding S Q. Application of electric stimulation therapy in treatment of fecal incontinence [J]. Chin J Gastroenterol, 2019, 24(8): 509-512.
36	王晓锋,刘素琴. 神经电刺激疗法治疗粪失禁现状与展望[J]. 结直肠肛门外科, 2015, 21(2): 76-80.
	Wang X F, Liu S Q. J Color Anal Surg, 2015, 21(2): 76-80.
37	郑霞霞,吴许雄,石荣. 骶神经刺激治疗盆底功能障碍性疾病的临床研究进展[J]. 甘肃医药, 2017, 36(10): 829-831.
	Zheng X X, Wu X X, Shi R. Gansu Med J, 2017, 36(10): 829-831.
38	代林志,张淙悦,郑政.超声神经刺激作用机制的研究现状[J]. 北京生物医学工程, 2020, 39(1): 103-107.
	Dai L Z, Zhang Z Y, Zheng Z. Research status on the mechanism of ultrasonic neurostimulation [J]. Beijing Biomed Engineer, 2020, 39(1): 103-107.

排名	论文来源国家	发文量(n)	主要病症
1	美国	17	尿失禁、大便失禁、尿频尿急
2	荷兰	13	排尿障碍、尿失禁、大便失禁
2	英国	13	大便失禁、便秘、排尿障碍
4	丹麦	11	大便失禁、尿失禁、肠易激综合征
5	澳大利亚	9	大便失禁、便秘、膀胱过度活动症
6	德国	8	排尿障碍、大便失禁、尿频尿急
6	意大利	8	大便失禁、尿失禁、特发性肛门疼痛
8	加拿大	6	排尿障碍、尿频尿急、便秘

排名	研究机构名称	发文量(n)	主要病症
1	Aarhus University Hospital	12	大便失禁、尿失禁、肠易激综合征
2	St Marks Hospital	9	大便失禁、便秘、排尿障碍
3	Royal Victoria Hospital	6	尿频尿急、排尿障碍等
3	Toronto Hospital	6	排尿障碍等
5	University of Colorado	5	尿失禁、大便失禁、尿频尿急
5	Acad Ziekenhuis	5	尿失禁、排尿障碍等
5	University of Minnesota	5	大便失禁、尿失禁等

[1]	LIU Ning, LIU Yuquan, ZHU Bin, YU Lingjia, TAN Haining, YANG Yong, LI Xiang. Application of International Standards for Neurological Classification of Spinal Cord Injury in China: a bibliometrics re-analysis [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2023, 29(7): 808-815.
[2]	WANG Haifang, XU Minjie, LI Ying, LEI Xiaojing, CHANG Jingling. Application of functional near-infrared spectroscopy in stroke: a visualized analysis [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2023, 29(12): 1405-1419.
[3]	HU Jiaquan, ZHU Liling, JIANG Zhimei. Early screening tools for autism spectrum disorder in the past two decades: a visualized analysis [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2023, 29(11): 1304-1315.
[4]	XU Hongli, ZHANG Qian, XUE Qing, YANG Yulin, MA Lihong, QIU Zhengang. Domestic and international researches related to postpartum rehabilitation in the last decade: a visualized analysis [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2023, 29(10): 1179-1188.
[5]	Feng XU,Qin ZHANG,Xiao-yun CHEN,Na XIE,Ting-ting JIN,Qian GAO. Advance in Researches of Low Back Pain: A Bibliometrics and Visualization Study [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2021, 27(3): 349-360.
[6]	ZHANG Yu-jing, LIAO Li-min, LI Wei, YAN Xiao-yan, LIU Xiao-yan, XU Wei. Requirements of Technical Review for Clinical Trial for Implantable Sacral Nerve Stimulation System [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2019, 25(4): 493-496.
[7]	YAN Rong-bao, QI Quan, LIU Yang, ZHAO Peng, LI Cheng-yong, YIN Xun-yi. Advance in Minocycline for Spinal Cord Injury (review) [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2019, 25(10): 1146-1149.
[8]	LÜWei;LI Zhi-gang;YAO Hai-jiang;MO Yu-ping;SONG Liang-yu;JING Quan-kai;SHI Su-hua. Research Progress of Acupuncture and Moxibustion on Spinal Cord Injury (review) [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2015, 21(12): 1411-1414.
[9]	YU Yan;ZHANG Feng-ren;YANG Zufu;et al.. Bibliometrics of China Rehabilitation Medicine Literature: Based on Science Citation Index [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2014, 20(3): 289-291.
[10]	TIAN Hong-mei;HAN Dong-mei;LIU Jia-rong;et al.. Preliminary Analysis of Literatures about Schizophrenia Rehabilitation in China [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2013, 19(09): 817-819.
[11]	REN Pei-juan;ZHANG Lin;WANG Yi-long;et al.. Quality Management of Design for Clinical Research of Pain [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2011, 17(11): 1023-1024.
[12]	HE Li-na;YUAN Zhang;CHEN Wei;et al. Advance in Empirical and Clinical Research of Electrical Stimulation for Spinal Cord Injury(review) [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2009, 15(08): 720-722.
[13]	LIU Gen-lin. A Preliminary Analysis of Teaching Strategy in Clinical Research Introduction of Rehabilitation [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2007, 13(08): 791-792.

Analysis of Characteristics of Clinical Researches on Sacral Nerve Stimulation Based on PubMed Database

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