帕金森病冲动控制障碍的Scoping综述

doi:10.3969/j.issn.1006-9771.2021.07.006

Abstract

Abstract:

Objective To explore the epidemiology, pathogenesis, risk factors, screening and evaluation, diagnostic strategies and treatment of impulse control disorder after Parkinson's disease (PD).

Methods Studies related to Parkinson's disease complicated with impulse control disorder were retrieved using subject search from PubMed, Medline, Embase, Cochrane Library, CNKI, VIP and Wanfang Data, until December, 2020, and supplemented by reference backtracking and manual retrieval.

Results A total of 2355 studies were returned first, and 30 were included, from ten countries, mainly published in journals about medicine, neurology, psychiatry, sleep medicine and movement disorders, etc., between 2010 and 2020. The researches mainly involved the pathogenesis, risk factors, screening and evaluation, diagnostic strategies and treatment.

Conclusion There are many risk factors for impulse control disorder in PD patients, mostly the dopaminergic drugs, especially dopamine receptor agonists. Interventions for impulse control disorders emphasize prevention and early identification. Individualized and symptomatic treatments based on adjustment of dopamine receptor agonists are needed.

Key words: Pakinson's disease, impulse control disorders, scoping review

CLC Number:

R742.5

XIAO Lin-na,LI Xiao-hong. Impulse Control Disorder in Parkinson's Disease: A Scoping Review[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2021, 27(7): 774-779.

Figures/Tables 2

分析构架		定义
冲动控制障碍		包括情绪和行为的自我控制问题且具有破坏性的冲动控制行为
病理性赌博		无法抵制冲动、欲望或诱惑去执行的一种典型的愉悦活动,由于过度进行这种活动最终会对个人或他人造成伤害。符合下列10条中至少5条可确诊：(1)终日思赌;(2)赌博进行性加重;(3)有过戒赌的想法或行动但未成功;(4)试图戒赌时出现生理不适感,如坐立不安、暴躁、心慌、出汗等;(5)利用赌博排解烦恼、逃离现实;(6)总相信输钱是暂时的,不能自拔;(7)对家人、朋友或医生隐瞒陷入赌博的程度;(8)因赌博出现犯罪行为;(9)丧失重要的人际关系,如家庭、工作,或失去受教育和就业的机会;(10)因赌博陷入债务危机
强迫性性行为		(1)性欲、性行为增多及异常的性行为。(2)上述症状持续存1个月以上。(3)至少存在以下一种情况：①已经对自身生活造成影响;②试图控制,但却无效;③消耗大量时间;④影响社会及职业功能。(4)此类性行为并非只发生在躁狂期。(5)如果除第(3)条外均满足,则称为亚临床表现。
强迫性进食		在短时间内周期性发作的大量进食,难以控制。诊断标准：(1)对饮食缺乏控制,反复多次、大量进食;(2)为防止超重而让自己呕吐、灌肠、滥用药物、运动或绝食;(3)每周至少发生1次,至少持续3个月;(4)对自己的体型及体质量作出不客观评价;(5)需排除发作时出现上述行为的神经性厌食者
强迫性购物		非正常的过度专注于购买,表现为不可抗拒冲动性购买行为,具有强迫性或无意识性,因购买过多不需要的物品而造成财务问题,且消耗时间过多,严重干扰社会和职业功能
危险因素	人口统计学特征	年纪较轻、社会文化因素(有赌博、上网的机会,有金融资源)、性别(女性暴饮暴食、强迫性购物居多,男性性欲亢进居多)
	发病前特征	吸烟史、冲动或寻求新奇人格、个人及家庭酗酒或赌博史、遗传学(多巴胺、血清素和谷氨酸系统)
	临床特征	使用多巴胺受体激动剂、DBS (STN)、左旋多巴当量日剂量高、金刚烷胺、雷沙吉兰、早发型帕金森病、长时间多巴胺受体激动剂治疗、抑郁、焦虑、RBD、妄想
	神经学特征	腹侧纹状体和中脑皮质系统影像学特征突出、认知扭曲(基于奖励的决策改变)

References 30

[1]	KELLY M J, BAIG F, HU M T, et al. Spectrum of impulse control behaviours in Parkinson's disease: pathophysiology and management[J]. Neurol Neurosurg Psychiatry, 2020, 91(7):703-711. doi: 10.1136/jnnp-2019-322453
[2]	MARQUES A, DURIF F, FERNAGUT P O. Impulse control disorders in Parkinson's disease[J]. J Neural Transm (Vienna), 2018, 125:1299-1312.
[3]	WEINTRAUB D, PAPAY K, SIDEROWF A. Parkinson's Progression Markers I. Screening for impulse control symptoms in patients with de novo Parkinson disease: a case-control study[J]. Neurology, 2013, 80:176-180. doi: 10.1212/WNL.0b013e31827b915c
[4]	WANNER V, GARCIA MALO C, ROMERO S, et al. Non-dopaminergic vs. dopaminergic treatment options in restless legs syndrome[J]. Adv Pharmacol, 2019, 84:187-205.
[5]	STARK A J, SMITH C T, LIN Y C, et al. Nigrostriatal and mesolimbic D2/3 receptor expression in Parkinson's disease patients with compulsive reward-driven behaviors[J]. J Neurosci, 2018, 38(13):3230-3239. doi: 10.1523/JNEUROSCI.3082-17.2018
[6]	LEE J Y, SEO S H, KIM Y K, et al. Extrastriatal dopaminergic changes in Parkinson's disease patients with impulse control disorders[J]. J Neurol Neurosurg Psychiatry, 2014, 85(1):23-30. doi: 10.1136/jnnp-2013-305549
[7]	PETERSEN K, VAN WOUWE N, STARK A, et al. Ventral striatal network connectivity reflects reward learning and behavior in patients with Parkinson's disease[J]. Hum Brain Mapp, 2018, 39(1):509-521. doi: 10.1002/hbm.23860
[8]	DREW D S, MUHAMMED K, BAIG F, et al. Dopamine and reward hypersensitivity in Parkinson's disease with impulse control disorder[J]. Brain, 2020, 143(8):2502-2518. doi: 10.1093/brain/awaa198
[9]	WEINTRAUB D, MAMIKONYAN E. Impulse control disorders in Parkinson's disease[J]. Am J Psychiatry, 2019, 176(1):5-11. doi: 10.1176/appi.ajp.2018.18040465
[10]	SMITH K M, XIE S X, WEINTRAUB D. Incident impulse control disorder symptoms and dopamine transporter imaging in Parkinson disease[J]. Neurol Neurosurg Psychiatry, 2016, 87(8):864-870. doi: 10.1136/jnnp-2015-311827
[11]	CORVOL J C, ARTAUD F, CORMIER-DEQUAIRE F, et al. Longitudinal analysis of impulse control disorders in Parkinson disease[J]. Neurology, 2018, 91(3):e189-e201. doi: 10.1212/WNL.0000000000005816
[12]	PEREZ-LLORET S, REY M V, FABRE N, et al. Prevalence and pharmacological factors associated with impulse-control disorder symptoms in patients with Parkinson disease[J]. Clin Neuropharmacol, 2012, 35(6):261-265. doi: 10.1097/WNF.0b013e31826e6e6d
[13]	MARQUES A, FIGORILLI M, PEREIRA B, et al. Impulse control disorders in Parkinson's disease patients with RLS: a cross sectional-study[J]. Sleep Med, 2018, 48:148-154. doi: 10.1016/j.sleep.2018.02.004
[14]	FANTINI M L, FIGORILLI M, ARNULF I, et al. Sleep and REM sleep behaviour disorder in Parkinson's disease with impulse control disorder[J]. Neurol Neurosurg Psychiatry, 2018, 89(3):305-310. doi: 10.1136/jnnp-2017-316576
[15]	FIGORILLI M, CONGIU P, LECCA R, et al. Sleep in Parkinson's disease with impulse control disorder[J]. Curr Neurol Neurosci Rep, 2018, 18(10):68. doi: 10.1007/s11910-018-0875-x
[16]	MARÍN-LAHOZ J, SAMPEDRO F, MARTINEZ-HORTA S, et al. Depression as a risk factor for impulse control disorders in Parkinson disease[J]. Ann Neurol, 2019, 86(5):762-769. doi: 10.1002/ana.v86.5
[17]	MORGANTE F, FASANO A, GINEVRINO M, et al. Impulsive-compulsive behaviors in Parkin-associated Parkinson disease[J]. Neurology, 2016, 87:1436-1441. doi: 10.1212/WNL.0000000000003177
[18]	CASTRO-MARTÍNEZ X H, GARCÍA-RUIZ P J, MARTÍNEZ-GARCÍA C, et al. Behavioral addictions in early-onset Parkinson disease are associated with DRD3 variants[J]. Parkinsonism Relat Disord, 2018, 49:100-103. doi: 10.1016/j.parkreldis.2018.01.010
[19]	American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders[M]. 5th ed. Washington D. C.: American Psychiatric Association, 2013.
[20]	HATTACHARJEE S. Impulse control disorders in Parkinson's disease: review of pathophysiology, epidemiology, clinical features, management, and future challenges[J]. Neurol India, 2018, 66(4):967-975. doi: 10.4103/0028-3886.237019
[21]	EVANS A H, OKAI D. Members of the International Parkinson and Movement Disorder Society (IPMDS) Rating Scales Review Committee. Scales to assess impulsive and compulsive behaviors in Parkinson's disease: critique andrecommendations[J]. Mov Disord, 2019, 34(6):791-798. doi: 10.1002/mds.v34.6
[22]	EVANS A H, KETTLEWELL J, MCGREGOR S, et al. A conditioned response as a measure of impulsive-compulsive behaviours in Parkinson's disease[J]. PLoS One, 2014, 9(2):e89319. doi: 10.1371/journal.pone.0089319
[23]	NAHAB F B, ABU-HUSSAIN H, MORENO L. Evaluation of clinical utility of the personal KinetiGraph in the management[J]. Adv Parkinson Dis, 2019, 8:42-61.
[24]	LEE J Y, JEON B, KOH S B, et al. Behavioural and trait changes in parkinsonian patients with impulse control disorder after switching from dopamine agonist to levodopa therapy: results of REIN-PD trial[J]. Neurol Neurosurg Psychiatry, 2019, 90(1):30-37. doi: 10.1136/jnnp-2018-318942
[25]	WARD S, SMITH N, BOWDEN-JONES H. The use of naltrexone in pathological and problem gambling: a UK case series[J]. Behav Addict, 2018, 7(3):827-833.
[26]	VRIEND C. The neurobiology of impulse control disorders in Parkinson's disease: from neurotransmitters to neural networks[J]. Cell Tissue Res, 2018, 373:327-336. doi: 10.1007/s00441-017-2771-0
[27]	JEON N, BORTOLATO M. What drugs modify the risk of iatrogenic impulse-control disorders in Parkinson's disease? A preliminary pharmacoepidemiologic study[J]. PLoS One, 2020, 15(1):e0227128. doi: 10.1371/journal.pone.0227128
[28]	LAPENTA O M, MARQUES L M, REGO G G, et al. tDCS in addiction and impulse control disorders[J]. J ECT, 2018, 34(3):182-192. doi: 10.1097/YCT.0000000000000541
[29]	KIM A, KIM Y E, KIM H J, et al. 7-year observation of the effect of subthalamic deep brain stimulation on impulse control disorder in patients with Parkinson's disease[J]. Parkinsonism Relat Disord, 2018, 56:3-8. doi: 10.1016/j.parkreldis.2018.07.010
[30]	OKAI D, ASKEY-JONES S, SAMUEL M, et al. Trial of CBT for impulse control behaviors affecting Parkinson patients and their caregivers[J]. Neurology, 2013, 80(9):792-799. doi: 10.1212/WNL.0b013e3182840678

研究	国家	研究对象	研究方法	干预方法	疗效	评估方法	用法	副作用
Ward等(2018)^[25]	英国	赌博患者	回顾性	纳曲酮	显著减少赌博欲望及行为	赌博欲望量表	起始25 mg,维持50 mg	食欲减退、胃肠疼痛、镇静状态、感觉异常
Vriend等(2018)^[26]	西班牙	帕金森病患者并发冲动控制障碍	前瞻性	唑尼沙胺	减轻症状严重程度	Barratt冲动量表/临床总体印象量表	起始25 mg,维持200 mg	注意力涣散、疲劳、感觉异常
Jeon等(2020)^[27]	美国	普拉克索/罗匹尼罗治疗的帕金森病患者	回顾性	谷氨酸能调节剂/选择性5-羟色胺再摄取抑制剂	无明显改善	–	–	增加发生冲动控制障碍的风险
Lapenta等(2018)^[28]	巴西	冲动控制障碍患者	回顾性	经颅直流电刺激	调节认知和运动功能	–	–	–
Kim等(2018)^[29]	韩国	帕金森病患者并发冲动控制障碍	前瞻性	STN-DBS	症状消失/减轻	明尼苏达冲动障碍访谈	–	出现新的短暂的冲动控制障碍
Okai等(2013)^[30]	英国	帕金森病患者并发冲动控制障碍	前瞻性	认知行为疗法	症状显著改善	冲动-强迫障碍问卷/临床总体印象量表/神经精神量表/冲动控制行为严重性量表	–	–

Impulse Control Disorder in Parkinson's Disease: A Scoping Review

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