运动减轻孤独症神经炎症的可视化分析

doi:10.3969/j.issn.1006-9771.2022.00.003

Abstract

Abstract:

Objective To explore the research hotspots and development trends in the field of autism spectrum disorder (ASD) in the past ten years, the literatures of microglia-related neuroinflammation of ASD and the immune regulation and possible pathways of exercise ameliorating ASD symptoms were reviewed.

Methods Articles about microglia-related research in ASD during January, 2012 to December, 2021 were searched in the core collection database of Web of Science. The CiteSpace 5.8.R3 software was used to summarize the main findings, visualize and analyze the annual publication volume, high-frequency keywords and keyword clustering.

Results and Conclusion A total of 783 papers were returned. The numbers of papers published increased with time. The neuroinflammation was a research hotspot in the pathogenesis of ASD, among which abnormal activation of microglia and the levels of inflammatory cytokines were important factors in the occurrence and development of ASD. Exercise was an important intervention to improve symptoms of ASD, which may associate with reducing neuroinflammation or regulating microglia-mediated inflammatory pathways.

Key words: autism spectrum disorder, neuroinflammation, microglia, exercise, visualized analysis

CLC Number:

R749.93

LAN Wanting,ZHONG Jiugen,SHEN Yingying,GONG Jiaheng,ZOU Zhi,HOU Xiaohui. Mechanism of exercise reducing neuroinflammation in autism spectrum disorder: a visualized analysis[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2022, 28(10): 1190-1197.

Figures/Tables 5

References 61

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细胞因子	研究对象	变化	参考文献
IL-1β	MIA模型小鼠	↑	Szabó等^[35] (2022)
IL-6	MIA 模型小鼠 ASD患者大脑组织	↑ ↑	Velloso等^[36] (2022) Li等^[27] (2009) Wei等^[37] (2011)
IL-8	ASD患者脑组织、脑脊液	↑	Vargas等^[7](2005)
IL-17	ASD模型小鼠	↑	Ahmad等^[30](2018)
IL-18	ASD模型小鼠	↑	Businaro等^[28] (2016)
TNF-α	ASD患者大脑组织 ASD患者脑脊液	↑ ↑	Li等^[27](2009) Chez等^[38](2007)
IFN-γ	ASD模型小鼠 ASD患者大脑组织	↑ ↑	Ahmad等^[30](2018) Li等^[27](2009)
GM-CSF	ASD患者大脑组织	↑	Li等^[27](2009)
MCP-1	ASD患者大脑组织	↑	Vargas等^[7](2005)
IL-2	MIA模型小鼠 ASD患者大脑组织	↑ ↓	Szabó等^[35]2022 Li等^[27](2009)
IL-10	ASD模型小鼠 ASD患者大脑组织	↓ ↓	Ahmad等^[30](2018) Li等^[27] (2009)

Mechanism of exercise reducing neuroinflammation in autism spectrum disorder: a visualized analysis

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序号	频次	关键词
1	396	autism spectrum disorder
2	390	microglia
3	290	central nervous system
4	245	neuroinflammation
5	157	gene expression
6	148	prefrontal cortex
7	113	mouse model
8	112	maternal immune activation
9	100	children
10	97	mousemodel
11	85	gut microbiota
12	82	cytokine
13	66	risk
14	65	behavior
15	36	sex difference
16	34	synaptic plasticity
17	23	astrocyte
18	22	model
19	21	cognitive deficit
20	20	pathway

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