电针对血管性认知障碍大鼠脑功能局部一致性的效果

doi:10.3969/j.issn.1006-9771.2022.01.009

Abstract

Abstract:

Objective To observe the effect of electroacupuncture at Baihui (DU20) and Shenting (DU24) on brain functional activity and working memory of rats with vascular cognitive impairment (VCI). Methods Eighteen Sprague-Dawley rats were included, in which twelve rats were ligated bilateral common carotid arteries and six rats were not ligated (sham group). The modeled rats were randomly divided into model group (n = 6) and electroacupuncture group (n = 6). The electroacupuncture group received electroacupuncture at Baihui and Shenting for four weeks. They were assessed with Y maze and Morris water maze before and after intervention, and scaned with resting-state functional magnetic resonance imaging after intervention to calculate regional homogeneity (ReHo). Results Compared with the sham group, alternation rate of Y maze decreased (P < 0.001), and escape latency of Morris water maze increased (P < 0.05) in the model group and the electroacupuncture group before intervention. Compared with the model group, alternation rate of Y maze increased (P < 0.05), and escape latency of Morris water maze decreased (P < 0.05) after intervention in the electroacupuncture group. Compared with the sham group, ReHo of bilateral hippocampus, olfactory cortex, sensory cortex and auditory cortex, and left striatum decreased in the model group; compared with the model group, ReHo of bilateral prefrontal lobe, hippocampus and olfactory cortex, and left amygdala increased in the electroacupuncture group. Conclusion Electroacupuncture at Baihui and Shenting can improve the memory function of VCI rats, which may be related to the functional activities of prefrontal lobes, hippocampus and amygdala.

Key words: vascular cognitive impairment, electroacupuncture, working memory, regional homogeneity

CLC Number:

R743.3

DING Yanyi,ZHANG Shenghang,LIU Yulu,YU Yan,YANG Minguang,LIANG Shengxiang,LIU Weilin,TAO Jing. Effect of electroacupuncture on regional homogeneity of brain function in rats with vascular cognitive impairment[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2022, 28(1): 55-61.

Figures/Tables 7

References 46

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组别	n	干预前	干预后
假手术组	6	78.03±3.90	78.37±8.83
模型组	6	59.83±4.17^a	58.77±5.44^a
电针组	6	63.56±6.78^a	68.31±5.61^b,c
F值		21.181	12.429
P值		< 0.001	0.001

组别	n	第一象限	第二象限	第三象限	第四象限
假手术组	6	27.89±18.49	18.07±10.67	21.87±14.84	18.56±12.40
模型组	6	51.17±8.35^a	40.21±18.02^a	42.85±14.7^a	41.72±19.19^a
电针组	6	47.25±18.87^a	40.12±18.06^a	43.67±14.75^a	49.38±13.79^a
F值		4.213	3.830	4.202	6.510
P值		0.035	0.045	0.036	0.009

组别	n	第一象限	第二象限	第三象限	第四象限
假手术组	6	17.04±11.85	15.96±8.85	13.69±10.43	15.24±9.48
模型组	6	49.34±9.59^a	45.65±14.65^a	43.30±12.21^a	41.76±12.29^a
电针组	6	24.86±13.51^b	26.63±15.65^b	27.66±8.27^a,b	24.90±16.14^b
F值		12.311	7.569	12.107	6.481
P值		0.001	0.005	<0.001	0.009

组别	n	干预前	干预后
假手术组	6	48.03±11.12	40.32±17.52
模型组	6	47.28±12.35	44.45±16.46
电针组	6	50.62±9.64	41.81±16.26
F值		0.149	0.094
P值		0.862	0.911

脑区	模型组 vs. 假手术组		电针组 vs. 模型组
脑区	体素	t值	体素	t值
左前额叶			1	3.878
右前额叶			7	5.288
左侧海马	1	3.750	6	4.370
右侧海马	23	5.359	72	6.232
左侧嗅觉皮质	3	4.059	13	4.534
右侧嗅觉皮质	4	3.928	7	4.062
左侧感觉皮质	64	5.186	-	-
右侧感觉皮质	26	4.759	-	-
左侧纹状体	17	4.704	1	3.846
左侧听觉皮质	14	4.458	-	-
右侧听觉皮质	13	4.982	8	4.817
右侧背侧丘脑外侧核群	2	4.109	-	-
左侧杏仁核	-	-	18	4.840
左侧中脑下丘	-	-	5	4.644
左侧中脑上丘	-	-	6	4.438
右侧中脑被盖	-	-	7	4.472
右侧梨状皮质	-	-	6	5.472

Effect of electroacupuncture on regional homogeneity of brain function in rats with vascular cognitive impairment

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