脑卒中后认知障碍患者静息态脑网络特征的功能性近红外光谱研究

doi:10.3969/j.issn.1006-9771.2022.04.011

Abstract

Abstract:

Objective To investigate the resting brain functional connectivity in patients with post-stroke cognitive impairment (PSCI).Methods From January, 2020 to January, 2021, 24 PSCI patients were divided into mild group (n=12) and moderate group (n=12) according to Mini-Mental State Examination and Montreal Cognitive Assessment scores; and other ten healthy controls (control group) were included. All the subjects were scanned with 64-channel functional near-infrared spectroscopy in resting for six minutes. The data were analyzed with NirSpark 1.6.12 and SPSS 26.0.Results Using deoxyhemoglobin, the functional connectivity between bilateral hemispheres reduced in the moderate group compared with those in the control group (t=-2.763, P=0.024), especially for the functional connectivity between sensorimotor cortexes (F=12.674, P=0.031).Conclusion Functional connectivity between hemispheres decreases in PSCI patients, especially between sensorimotor cortexes.

Key words: stroke, cognitive impairment, resting brain network, functional near-infrared spectroscopy

LU Jiamin,YAN Sinian,CHEN Yihao,LU Rongrong,WU Yi. Characteristics of resting brain network for patients with cognitive impairment after stroke using functional near-infrared spectroscopy[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2022, 28(4): 447-452.

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References 19

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组别	n	性别(男/女)/n	年龄/岁	卒中部位(左/右)/n	损伤类型(梗死/出血)/n	体质量指数/kg·m^-2	受教育年限/年
对照组	10	4/6	54.68±5.85	-	-	22.59±3.38	12.4±3.31
轻度组	12	9/3	45±13.33	8/4	6/6	22.99±2.87	15.33±2.84
中度组	12	9/3	55.88±11.14	9/3	7/5	23.26±2.61	11±3.62
χ²₁/t₁值		2.764	2.108	-	-	-0.299	-2.240
P₁值		0.096	0.046	-	-	0.767	0.037
χ²₂/t₂值		2.764	-0.123	-	-	-0.532	0.939
P₂值		0.096	0.763	-	-	0.605	0.359
χ²₃/t₃值		0.000	-2.010	0.202	0.168	-0.252	3.264
P₃值		1.000	0.041	0.653	0.682	0.812	0.036

差异源	平方和	自由度	均方	F值	P值
截距	7.116	1	7.116	674.699	< 0.001
血红蛋白类型	0.360	2	0.180	17.090	< 0.001
连接类型	0.021	2	0.010	0.982	0.384
血红白蛋类型×连接类型	0.001	4	0.000	0.023	0.999
残差	0.380	36	0.011	-	-

差异源	平方和	自由度	均方	F值	P值
截距	6.871	1	6.871	869.985	< 0.001
血红蛋白类型	0.418	2	0.209	26.472	< 0.001
连接类型	0.003	2	0.001	0.159	0.854
血红白蛋类型×连接类型	0.003	4	0.001	0.086	0.986
残差	0.284	36	0.008	-	-

差异源	平方和	自由度	均方	F值	P值
截距	5.832	1	5.832	794.628	< 0.001
血红蛋白类型	0.560	2	0.280	38.150	< 0.001
连接类型	0.005	2	0.002	0.327	0.723
血红白蛋类型×连接类型	0.002	4	0.001	0.084	0.987
残差	0.264	36	0.007	-	-

差异源	平方和	自由度	均方	F值	P值
截距	2.652	1	2.652	544.649	< 0.001
组别	0.038	2	0.019	3.950	0.028
连接类型	0.009	2	0.004	0.882	0.423
组别×连接类型	0.007	4	0.002	0.353	0.840
残差	0.175	36	0.005	-	-

Characteristics of resting brain network for patients with cognitive impairment after stroke using functional near-infrared spectroscopy

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连接类型	组别	均值差	SE	t值	P值
半球间	中度-对照	-0.091	0.033	-2.763	0.024
半球间	中度-轻度	-0.052	0.033	-1.591	0.263
半球间	对照-轻度	0.039	0.033	1.173	0.477
右半球内	中度-对照	-0.067	0.057	-1.172	0.477
右半球内	中度-轻度	-0.096	0.057	-1.692	0.222
右半球内	对照-轻度	-0.030	0.057	-0.520	0.862
左半球内	中度-对照	-0.077	0.057	-1.343	0.381
左半球内	中度-轻度	-0.030	0.057	-0.518	0.863
左半球内	对照-轻度	0.047	0.057	0.825	0.690

通道	对照组	中度组	F值	P值
LPFC-RPFC	0.329	0.288	0.392	0.621
LPFC-LSMC	0.284	0.236	1.291	0.348
LPFC-RSMC	0.257	0.187	2.304	0.273
LPFC-LOL	0.287	0.230	1.247	0.348
LPFC-ROL	0.206	0.191	0.071	0.849
RPFC-LSMC	0.277	0.185	2.648	0.273
RPFC-RSMC	0.288	0.197	2.400	0.273
RPFC-LOL	0.256	0.173	3.071	0.273
RPFC-ROL	0.196	0.186	0.025	0.875
LSMC-RSMC	0.482	0.277	12.674	0.031
LSMC-LOL	0.432	0.308	4.286	0.261
LSMC-ROL	0.341	0.260	1.769	0.322
RSMC-LOL	0.337	0.197	6.681	0.136
RSMC-ROL	0.311	0.211	3.191	0.273
LOL-ROL	0.455	0.365	1.649	0.322

差异源	平方和	自由度	均方	F值	P值
截距	9.227	1	9.227	971.631	< 0.001
组别	0.011	2	0.006	0.595	0.557
连接类型	0.008	2	0.004	0.431	0.653
组别×连接类型	0.002	4	0.000	0.043	0.996
残差	0.342	36	0.009	-	-

差异源	平方和	自由度	均方	F值	P值
截距	9.226	1	9.226	808.111	< 0.001
组别	0.001	2	0.001	0.061	0.941
连接类型	0.008	2	0.004	0.331	0.721
组别×连接类型	0.001	4	0.000	0.029	0.998
残差	0.411	36	0.011	-	-

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