基于功能性近红外光谱技术的脑卒中后上肢运动功能障碍患者单侧上肢训练和双侧上肢训练脑网络功能连接对比研究

doi:10.3969/j.issn.1006-9771.2022.05.001

Abstract

Abstract:

Objective To compare the functional connectivity of brain networks in stroke patients with upper limb motor dysfunction during unilateral or bilateral upper limb movement using functional near-infrared spectroscopy (fNIRS). Methods From April to June, 2021, 40 stroke patients with upper limb motor dysfunction in Department of Rehabilitation Medicine, Huashan Hospital, finished unilateral (affected) and bilateral upper limb movement. Eight-minute fNIRS data were collected before and after movement, and the functional activities and connectivity of prefrontal cortex (PFC), upper limb and hand functional area (H), primary sensory cortex (S1) were analyzed based on oxygenated hemoglobin. Results Functional activities increased in affected H after unilateral task (t = -3.135, P < 0.05), while the functional connectivity increased between affected H and affected S1, affected H and unaffected S1, and affected S1 and unaffected S1 (|t| > 3.218, P < 0.05). There was no significant difference in the functional activities and connectivity of all the areas after bilateral upper limb task (|t| < 2.385, P > 0.05). The improvement of affected H was more after unilateral task than after bilateral upper limb task (t = 2.026, P < 0.05). Conclusion Unilateral affected upper limb training is more effective on functional activities and connectivity for corresponding brain regions than bilateral task.

Key words: stroke, upper limb, motor dysfunction, functional near-infrared spectroscopy, brain functional connectivity

CLC Number:

R743.3

TIAN Jing,LIU Jue,HE Zhijie,FAN Chenyu,LI Haozheng,YANG Qing,WU Yi,YU Kewei. Brain network functional connectivity as unilateral or bilateral upper limb training for patients with upper limb motor dysfunction after stroke: study with functional near-infrared spectroscopy[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2022, 28(5): 497-501.

Figures/Tables 6

References 29

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ROI	任务前	任务后	t值	P值
L-PFC	0.615±0.050	0.680±0.054	-1.388	0.208
R-PFC	0.665±0.045	0.697±0.047	-0.933	0.356
L-H	0.918±0.066	1.105±0.071	-3.135	0.020
R-H	0.955±0.061	1.062±0.068	-1.702	0.145
L-S1	0.806±0.059	0.940±0.070	-2.064	0.091
R-S1	0.820±0.059	0.974±0.077	-2.315	0.078

ROI	任务前	任务后	t值	P值
L-PFC/R-PFC	0.487±0.034	0.514±0.043	-0.741	0.496
L-PFC/L-H	0.455±0.033	0.505±0.044	-1.364	0.246
L-PFC/R-H	0.432±0.035	0.517±0.042	-1.990	0.115
L-PFC/L-S1	0.465±0.037	0.522±0.047	-1.395	0.246
L-PFC/R-S1	0.426±0.038	0.495±0.044	-1.837	0.138
R-PFC/L-H	0.431±0.024	0.475±0.036	-1.310	0.247
R-PFC/R-H	0.450±0.026	0.506±0.038	-1.371	0.246
R-PFC/L-S1	0.450±0.033	0.459±0.039	-0.264	0.793
R-PFC/R-S1	0.467±0.31	0.516±0.042	-1.228	0.262
L-H/R-H	0.745±0.048	0.876±0.061	-2.362	0.079
L-H/L-S1	0.684±0.047	0.835±0.056	-3.218	0.031
L-H/R-S1	0.569±0.038	0.703±0.055	-2.894	0.031
R-H/L-S1	0.590±0.041	0.703±0.055	-2.229	0.079
R-H/R-S1	0.704±0.048	0.810±0.060	-2.257	0.079
L-S1/R-S1	0.566±0.041	0.737±0.062	-3.031	0.031

ROI	任务前	任务后	t值	P值
L-PFC	0.688±0.066	0.698±0.060	-0.252	0.889
R-PFC	0.659±0.060	0.708±0.061	-1.008	0.889
L-H	1.020±0.065	1.029±0.067	-0.141	0.889
R-H	1.030±0.066	1.011±0.067	0.290	0.889
L-S1	0.841±0.069	0.978±0.069	-1.848	0.433
R-S1	0.887±0.070	0.931±0.071	-0.770	0.889

ROI	任务前	任务后	t值	P值
L-PFC/R-PFC	0.503±0.048	0.562±0.047	-1.523	0.387
L-PFC/L-H	0.463±0.044	0.509±0.038	-1.214	0.387
L-PFC/R-H	0.464±0.042	0.472±0.039	-0.179	0.859
L-PFC/L-S1	0.448±0.045	0.533±0.043	-2.370	0.129
L-PFC/R-S1	0.430±0.042	0.481±0.041	-1.345	0.387
R-PFC/L-H	0.420±0.035	0.479±0.036	-1.663	0.387
R-PFC/R-H	0.463±0.039	0.486±0.043	-0.602	0.635
R-PFC/L-S1	0.424±0.037	0.506±0.041	-2.385	0.129
R-PFC/R-S1	0.470±0.045	0.555±0.042	-2.317	0.129
L-H/R-H	0.840±0.052	0.862±0.059	-0.379	0.757
L-H/L-S1	0.762±0.053	0.823±0.057	-1.081	0.430
L-H/R-S1	0.633±0.048	0.690±0.049	-1.285	0.387
R-H/L-S1	0.660±0.045	0.700±0.053	-0.805	0.542
R-H/R-S1	0.754±0.058	0.793±0.054	-0.791	0.542
L-S1/R-S1	0.616±0.045	0.678±0.058	-1.302	0.387

ROI	单侧任务	双侧任务	t值	P值
L-PFC	0.066±0.047	0.009±0.042	0.898	0.372
R-PFC	0.032±0.035	0.048±0.049	-0.268	0.789
L-H	0.188±0.060	0.008±0.066	2.026	0.046
R-H	0.107±0.063	-0.026±0.065	1.463	0.147
L-S1	0.135±0.065	0.131±0.074	0.036	0.972
R-S1	0.154±0.066	0.041±0.057	1.296	0.199
L-PFC/R-PFC	0.028±0.038	0.058±0.038	-0.557	0.579
L-PFC/L-H	0.051±0.037	0.046±0.038	0.087	0.931
L-PFC/R-H	0.085±0.042	0.006±0.043	1.302	0.197
L-PFC/L-S1	0.058±0.041	0.083±0.036	-0.459	0.648
L-PFC/R-S1	0.069±0.037	0.050±0.038	0.349	0.728
R-PFC/L-H	0.044±0.034	0.058±0.035	-0.288	0.774
R-PFC/R-H	0.056±0.041	0.022±0.038	0.613	0.542
R-PFC/L-S1	0.010±0.037	0.081±0.034	-1.419	0.160
R-PFC/R-S1	0.049±0.040	0.084±0.037	-0.650	0.518
L-H/R-H	0.131±0.056	0.019±0.059	1.387	0.169
L-H/L-S1	0.152±0.047	0.059±0.057	1.257	0.212
L-H/R-S1	0.133±0.046	0.056±0.044	1.203	0.233
R-H/L-S1	0.113±0.051	0.037±0.050	1.069	0.288
R-H/R-S1	0.107±0.047	0.037±0.049	1.020	0.311
L-S1/R-S1	0.172±0.057	0.061±0.048	1.503	0.137

Brain network functional connectivity as unilateral or bilateral upper limb training for patients with upper limb motor dysfunction after stroke: study with functional near-infrared spectroscopy

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